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ACAAI BOARD REVIEW BOOK > CD markers, Chemokines, receptors, memorization stuff > Flashcards

CD markers, Chemokines, receptors, memorization stuff Flashcards

1
Q

CD marker for hematopoetic stem cell

A

CD34

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2
Q

WBC CD markers

A

CD45

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3
Q

Granulocyte CD markers

A

CD45+; CD 15+

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4
Q

monocyte CD markers

A

CD45+; CD14+

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5
Q

B cell CD markers

A

CD45, CD19, 20, 21, 81

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6
Q

mature naive B cell

A

CD19 +Igm or IgD

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7
Q

mature B cell CD markers

A

CD19 and CD21

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8
Q

switched memory B cell

A

CD27 IgD or IgM -

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9
Q

plasma cell

A

CD19, CD 27, CD38+

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10
Q

what CD marker do most B cells in CLL have

A

CD5+

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11
Q

NK cell

A

CD45, CD2, CD16, CD56

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12
Q

NKT cell

A

CD45, CD3, CD16, CD56 (CD3 is the distinguishing marker from NK cells)

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13
Q

platelet CD markers

A

CD41, CD 61

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14
Q

what is CD1? what cells is it important on and what is a primary function?

A

presents lipid antigens; present on APCs and is immunoglobulin family member; binds to B2 microglobulin

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15
Q

what is another name for CD2? and what is its function?

A

LFA2 and activates T lymphocytes

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16
Q

what cells can you find CD3? what receptor family does it belong to? what is its main function?

A

all T lymphocytes (and NKT cells); it belongs to Ig family; part of TCR and important for signal transduction; made up of delta, epsilon, gamma and zeta chain and defect in any of these leads to T-B+NK+ SCID

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17
Q

what is another name for CD11a? what does it associate with and what does it bind?

A

LFA1 (an integrin on T, B, NK cells, granulocytes and monocytes); it associates with CD18; binds to ICAM; important for cell-cell adhesion

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18
Q

what is the receptor (CD) for LPS on macrophages and monocytes?

A

CD 14- mediates IL12 and IFNy production

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19
Q

what is the most common IgG FcR? and its CD marker?

A

FCyRIIIA= CD 16; on NK and macrophages and mediates ADCC; FCyRIIIB also CD16 mediates phagocytosis in neutrophils

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20
Q

what is CD 18? what does it associate with and what is its function?

A

B2 integrin; associates with CD11 and is important for leukocyte adhesion; if mutated=LAD1

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21
Q

what is CD 19? what is an important role and what is the structure?`

A

C cell co-receptor (with CD21 or CD81) on all B cells; Ig family

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22
Q

what is CD20?

A

B cell activating factor

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23
Q

what is another name for CD21? what are two clinically relevant viruses that utilize this receptor and what cells is it expressed on?

A

complement receptor 2 (CR2); on mature and follicular B cells; binds EBV and HHV8. also binds C3d and CD23 (low affinity FCeRII)

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24
Q

what is another name for CD23?

A

FCeRII (low affinity); regulates IgE synthesis

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25
Q

what is CD25? clinical relevance?

A

IL2Ra; on activated T and B cells; regulates self-reactive lymphocytes; prevents CTL cytoloysis, suppresses NK cells; if mutated, can have an ALPS/immunodeficiency phenotype. is also elevated in HLH and some B cell neoplasms

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26
Q

what is another name for CD31?

A

PECAM1 on granulocytes

27
Q

what is CD 32? and primary role?

A

FcyRII on WBCs; low affinity IgG receptor to clear immune complexes; proposed mechanism of IVIG

28
Q

what is another name for CD35?

A

complement receptor 1 (CR1); binds immune complexes coated with C3b and C4b; cofactor for I-mediated cleavage

29
Q

name 3 important CD markers that are part of TNF receptor family?

A

CD 27 (memory B cell marker); CD 40 (on APCs) for T cell dependent class switching, also CD40L; CD 95 (Fas) on activated B and T cells, also CD178 (FasL)

30
Q

what is the receptor for adenovirus (CD)?

A

CD 46

31
Q

what monoclonal Ab is targeted at CD52 and for what disease?

A

alemtuzumab (Campath) in CLL

32
Q

what is another name for CD54? what cells is it on? primary role?

A

ICAM1; on all cells; important for cell adhesion; binds to LFA1 (CD11/CD18)

33
Q

what is the receptor for rhinovirus A & B? CD?

A

ICAM1 (CD 54)

34
Q

what is the receptor for rhinovirus C?

A

CDHR3 (cadherin related family member 3)

35
Q

what is another name for CD 55? what disease does it have relevance for?

A

Decay accelerating factor (accelerates decay of C3 convertase by binding C3bBb and C4b2a); implicated in paroxysmal nocturnal hemoglobinuria

36
Q

what does CD59 do?

A

binds C8 and C9 to inhibit MAC formation

37
Q

what is CD62L? what cells is it on? what does is bind?

A

L-selectin on lymphocytes; binds to CD34, MadCam and GlyCam

38
Q

what is the CD marker for the high affinity FC IgG receptor?

A

CD 64

39
Q

other names for CD 80/86? Cells on? structure? ligands? function?

A

B71 and B72; on APC; immunoglobulin super family; binds to CD 28 (activating) or CTLA4 (inhibitor); necessary for co-stimulation (i.e. signal #2)

40
Q

this CD marker is defective in ALPS

A

CD95 (fas)

41
Q

what is another name for CD106? ligand?

A

VCAM1 (on endothelium, fibroblasts, respiratory epithelium); binds to VLA4 (a4;B1 or CD49d)

42
Q

what is the stem cell factor receptor CD? what is it mutated in?

A

CD 117; c kit mutation in systemic mastocytosis

43
Q

what is the CD marker for CTLA4? ligands?

A

CD152; binds CD 80, 86 on APCs and is inhibitory signal

44
Q

what is CD 154? mutation leads to what disease?

A

CD40L; x-linked hyper IgM

45
Q

what is another name for CD 158? cells? function?

A

KIRs on NK cells; bind MHC I and inhibits NK killing

46
Q

which cells express MHC class I?

A

all nucleated cells

47
Q

which cells express MHC class II

A

dendritic cells, macrophages, monocytes, B cells, CD4 T cells

48
Q

CLA-1 is a cell surface marker found on what cells and mediates what?

A

on T cells and facilitates homing to skin

49
Q

a4B7 on T cells mediates homing to what tissue and binds what?

A

gut; MadCam1

50
Q

clinical relevance of OX40 Ligand?

A

TNF superfam receptor; implicated in cytokine storm of H1N1

51
Q

what is the structure of the receptor for lymphotoxin?

A

TNF Receptor family; mediates apoptosis

52
Q

what is another name for CR3?

A

CD11b/CD18 (Mac-1); most potent complement receptor and binds iC3b; also binds ICAM

53
Q

what is CR4 also known as? ligand?

A

p150.95 (CD11c/CD18); binds ICAM3

54
Q

what chemokine receptors do eotaxin (CCL11) and RANTES (CCL5) bind to?

A

CR3 and CR5

55
Q

what are the ligands for CCR4?

A

CCL17 (TARC) and CCL22 (MDC)

56
Q

CCR7 binds to what ligands? function?

A

CCL19 and 21; tracking to lymph nodes of naive T cells and activated dendritic cells

57
Q

what is the ligand for CXCR5 and function?

A

CXCL13; B cell homing to B-T cell zone in Lymph nodes

58
Q

an activating mutation in CXCR4 leads to what disease?

A

WHIM (warts, hypogamm, infection, myelokathexis); retention in bone marrow

59
Q

what is HLA-DR CD4 and CD8?

A

activation markers

60
Q

what mitogen stimulates both B and T cells?

A

pokeweed

61
Q

what mitogen is somewhat specific to CD8 proliferation?

A

conA

62
Q

what CD cell surface marker is indicative of NK cell degranulation?

A

CD107a

63
Q

what is CD15s? What disease state is implicated?

A

sialyl Lewis X; LAD type II; Bombay phenotype

64
Q

what is the CD88 receptor bind to? and what cells is it present on?

A

binds C5a anaphylotoxin; present on MCtc mast cells

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