CD markers, Chemokines, receptors, memorization stuff

Question 1

CD marker for hematopoetic stem cell

Answer 1

CD34

Question 2

WBC CD markers

Answer 2

CD45

Question 3

Granulocyte CD markers

Answer 3

CD45+; CD 15+

Question 4

monocyte CD markers

Answer 4

CD45+; CD14+

Question 5

B cell CD markers

Answer 5

CD45, CD19, 20, 21, 81

Question 6

mature naive B cell

Answer 6

CD19 +Igm or IgD

Question 7

mature B cell CD markers

Answer 7

CD19 and CD21

Question 8

switched memory B cell

Answer 8

CD27 IgD or IgM -

Question 9

plasma cell

Answer 9

CD19, CD 27, CD38+

Question 10

what CD marker do most B cells in CLL have

Answer 10

CD5+

Question 11

NK cell

Answer 11

CD45, CD2, CD16, CD56

Question 12

NKT cell

Answer 12

CD45, CD3, CD16, CD56 (CD3 is the distinguishing marker from NK cells)

Question 13

platelet CD markers

Answer 13

CD41, CD 61

Question 14

what is CD1? what cells is it important on and what is a primary function?

Answer 14

presents lipid antigens; present on APCs and is immunoglobulin family member; binds to B2 microglobulin

Question 15

what is another name for CD2? and what is its function?

Answer 15

LFA2 and activates T lymphocytes

Question 16

what cells can you find CD3? what receptor family does it belong to? what is its main function?

Answer 16

all T lymphocytes (and NKT cells); it belongs to Ig family; part of TCR and important for signal transduction; made up of delta, epsilon, gamma and zeta chain and defect in any of these leads to T-B+NK+ SCID

Question 17

what is another name for CD11a? what does it associate with and what does it bind?

Answer 17

LFA1 (an integrin on T, B, NK cells, granulocytes and monocytes); it associates with CD18; binds to ICAM; important for cell-cell adhesion

Question 18

what is the receptor (CD) for LPS on macrophages and monocytes?

Answer 18

CD 14- mediates IL12 and IFNy production

Question 19

what is the most common IgG FcR? and its CD marker?

Answer 19

FCyRIIIA= CD 16; on NK and macrophages and mediates ADCC; FCyRIIIB also CD16 mediates phagocytosis in neutrophils

Question 20

what is CD 18? what does it associate with and what is its function?

Answer 20

B2 integrin; associates with CD11 and is important for leukocyte adhesion; if mutated=LAD1

Question 21

what is CD 19? what is an important role and what is the structure?`

Answer 21

C cell co-receptor (with CD21 or CD81) on all B cells; Ig family

Question 22

what is CD20?

Answer 22

B cell activating factor

Question 23

what is another name for CD21? what are two clinically relevant viruses that utilize this receptor and what cells is it expressed on?

Answer 23

complement receptor 2 (CR2); on mature and follicular B cells; binds EBV and HHV8. also binds C3d and CD23 (low affinity FCeRII)

Question 24

what is another name for CD23?

Answer 24

FCeRII (low affinity); regulates IgE synthesis

Question 25

what is CD25? clinical relevance?

Answer 25

IL2Ra; on activated T and B cells; regulates self-reactive lymphocytes; prevents CTL cytoloysis, suppresses NK cells; if mutated, can have an ALPS/immunodeficiency phenotype. is also elevated in HLH and some B cell neoplasms

Question 26

what is another name for CD31?

Answer 26

PECAM1 on granulocytes

Question 27

what is CD 32? and primary role?

Answer 27

FcyRII on WBCs; low affinity IgG receptor to clear immune complexes; proposed mechanism of IVIG

Question 28

what is another name for CD35?

Answer 28

complement receptor 1 (CR1); binds immune complexes coated with C3b and C4b; cofactor for I-mediated cleavage

Question 29

name 3 important CD markers that are part of TNF receptor family?

Answer 29

CD 27 (memory B cell marker); CD 40 (on APCs) for T cell dependent class switching, also CD40L; CD 95 (Fas) on activated B and T cells, also CD178 (FasL)

Question 30

what is the receptor for adenovirus (CD)?

Answer 30

CD 46

Question 31

what monoclonal Ab is targeted at CD52 and for what disease?

Answer 31

alemtuzumab (Campath) in CLL

Question 32

what is another name for CD54? what cells is it on? primary role?

Answer 32

ICAM1; on all cells; important for cell adhesion; binds to LFA1 (CD11/CD18)

Question 33

what is the receptor for rhinovirus A & B? CD?

Answer 33

ICAM1 (CD 54)

Question 34

what is the receptor for rhinovirus C?

Answer 34

CDHR3 (cadherin related family member 3)

Question 35

what is another name for CD 55? what disease does it have relevance for?

Answer 35

Decay accelerating factor (accelerates decay of C3 convertase by binding C3bBb and C4b2a); implicated in paroxysmal nocturnal hemoglobinuria

Question 36

what does CD59 do?

Answer 36

binds C8 and C9 to inhibit MAC formation

Question 37

what is CD62L? what cells is it on? what does is bind?

Answer 37

L-selectin on lymphocytes; binds to CD34, MadCam and GlyCam

Question 38

what is the CD marker for the high affinity FC IgG receptor?

Answer 38

CD 64

Question 39

other names for CD 80/86? Cells on? structure? ligands? function?

Answer 39

B71 and B72; on APC; immunoglobulin super family; binds to CD 28 (activating) or CTLA4 (inhibitor); necessary for co-stimulation (i.e. signal #2)

Question 40

this CD marker is defective in ALPS

Answer 40

CD95 (fas)

Question 41

what is another name for CD106? ligand?

Answer 41

VCAM1 (on endothelium, fibroblasts, respiratory epithelium); binds to VLA4 (a4;B1 or CD49d)

Question 42

what is the stem cell factor receptor CD? what is it mutated in?

Answer 42

CD 117; c kit mutation in systemic mastocytosis

Question 43

what is the CD marker for CTLA4? ligands?

Answer 43

CD152; binds CD 80, 86 on APCs and is inhibitory signal

Question 44

what is CD 154? mutation leads to what disease?

Answer 44

CD40L; x-linked hyper IgM

Question 45

what is another name for CD 158? cells? function?

Answer 45

KIRs on NK cells; bind MHC I and inhibits NK killing

Question 46

which cells express MHC class I?

Answer 46

all nucleated cells

Question 47

which cells express MHC class II

Answer 47

dendritic cells, macrophages, monocytes, B cells, CD4 T cells

Question 48

CLA-1 is a cell surface marker found on what cells and mediates what?

Answer 48

on T cells and facilitates homing to skin

Question 49

a4B7 on T cells mediates homing to what tissue and binds what?

Answer 49

gut; MadCam1

Question 50

clinical relevance of OX40 Ligand?

Answer 50

TNF superfam receptor; implicated in cytokine storm of H1N1

Question 51

what is the structure of the receptor for lymphotoxin?

Answer 51

TNF Receptor family; mediates apoptosis

Question 52

what is another name for CR3?

Answer 52

CD11b/CD18 (Mac-1); most potent complement receptor and binds iC3b; also binds ICAM

Question 53

what is CR4 also known as? ligand?

Answer 53

p150.95 (CD11c/CD18); binds ICAM3

Question 54

what chemokine receptors do eotaxin (CCL11) and RANTES (CCL5) bind to?

Answer 54

CR3 and CR5

Question 55

what are the ligands for CCR4?

Answer 55

CCL17 (TARC) and CCL22 (MDC)

Question 56

CCR7 binds to what ligands? function?

Answer 56

CCL19 and 21; tracking to lymph nodes of naive T cells and activated dendritic cells

Question 57

what is the ligand for CXCR5 and function?

Answer 57

CXCL13; B cell homing to B-T cell zone in Lymph nodes

Question 58

an activating mutation in CXCR4 leads to what disease?

Answer 58

WHIM (warts, hypogamm, infection, myelokathexis); retention in bone marrow

Question 59

what is HLA-DR CD4 and CD8?

Answer 59

activation markers

Question 60

what mitogen stimulates both B and T cells?

Answer 60

pokeweed

Question 61

what mitogen is somewhat specific to CD8 proliferation?

Answer 61

conA

Question 62

what CD cell surface marker is indicative of NK cell degranulation?

Answer 62

CD107a

Question 63

what is CD15s? What disease state is implicated?

Answer 63

sialyl Lewis X; LAD type II; Bombay phenotype

Question 64

what is the CD88 receptor bind to? and what cells is it present on?

Answer 64

binds C5a anaphylotoxin; present on MCtc mast cells