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REVIEW > CC LIPOPROTEINS > Flashcards

CC LIPOPROTEINS Flashcards

1
Q

is absorbed by CM and delivered by VLDL and LDL

A

vit. E

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2
Q

does not require CM for absorption

A

vit. D

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3
Q

independent from lipoproteins

A

vit. A, K

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4
Q

proteins responsible for solubility of lipids in blood
- structural integrity of lipoproteins

A

apolipoproteins

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5
Q

plasma conc. of B-48

A

< 5

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6
Q

efflux of cholesterol from peripheral cells towards the HDL

A

ABCA

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7
Q

esterification of free cholesterol to cholesterol ester

A

LCAT

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8
Q

hydrolyze TAG and phospholipids from HDL

A

endothelial lipase

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9
Q

hydrolyze TAG and phospholipids from HDL, IDL, and VLDL

A

Hepatic lipase

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10
Q

hydrolyze TAG and CHOLE from HDL

A

LPP LIPASE

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11
Q

Most non-atherogenic LPP
largest and least dense

A

chylomicrons

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12
Q

chylomicrons are completely cleared after __ hours of fasting

A

6-9 hrs

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13
Q

apolipoproteins of chylomicrons

A

B-48
A-I
C
E

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14
Q

reverse cholesterol transport
-cardioprotective

A

HDL

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14
Q

Nascent disk-shaped particles
alpha lipoprotein
smallest most dense

A

HDL

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15
Q

Atherogenic transporter of TAG
pre-beta lipoprotein
-transport endogenous TAG exported by the liver

A

VLDL

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16
Q

apolipoproteins of VLDL

A

B-100
C
E

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17
Q

Most atherogenic
Beta lipoprotein
measure indirectly
“most cholesterol rich”

A

LDL

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18
Q

forward cholesterol transport

A

LDL

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19
Q

apolipoproteins of LDL

A

B-100
E

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20
Q

Product of VLDL catabolism
converted to LDL
-NOT MEASURED IN HEALTHY SERUM

A

IDL

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21
Q

Found in px with obstructive jaundice and LCAT deficiency

A

LP X

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22
Q

Sinking pre-beta lipoprotein
LDL-like variant
independent risk factor of atherosclerosis

A

Lp (a)

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23
Q

floating beta lipoprotein
migrates abnormally in the beta regions, instead of the pre-beta region

A

B-VLDL

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24
Q

Reference method for LPP quantification/ golden standard for LPP quantitative determination
-using salt reagent

A

ULTRACENTRIFUGATION

25
Q

reagent used for ULTRACENTRIFUGATION

A

potassium bromide

26
Q

migration of LPP based on their protein content

A

ELECTROPHORESIS

27
Q

lipid staining dyes

A

oil red 0
fat red 7B
sudan black B

28
Q

preferred support medium for electrophoresis

A

barbital/veronal

29
Q

enzymatic tests coupled with detergent precipitation is the most useful LPP test

A

chemical precipitation

30
Q

most popular method for HDL

A

homogeneous HDL-C assay

31
Q

pH for barbital/veronal

A

8.6

32
Q

beta quantification running timee

A

18 hours

33
Q

test for lipoproteins that needs fasting

A

LDL-C
TAG

34
Q

test for lipoproteins that doesn’t need fasting

A

HDL-C
TC

35
Q

fluid of choice in routine clin lab

A

SST SERUM

36
Q

lipoprotein lipase enzyme deficiency
TAG= 10,000 MG/DL (always milky despite over fasting)

A

type 1 hyperchylomicronemia

37
Q

LDL receptor defect

A

type 2a hypercholesterolemia

38
Q

Dysbetalipoproteinemia
-presence of B-VLDL and IDL

A

type 3a hyperlipoproteinemia

39
Q

yellowish deposits of cholesterol under the skin, usually present around the eyelids

A

xanthelasma

40
Q

Apo B synthesis defect
aka Bassen-kornzweig syndrome
-presence of acanthocytosis in the blood

A

Abetalipoproteinemia

41
Q

no HDL produced
at chromosome 9 there is no presence of of ABCA 1 gene

A

Tanger’s disease

42
Q

B-glucocerebrosidase deficiency
-most common cause of lipidosis

A

Gaucher’s disease

43
Q

Hexosaminidase deficiency
- sphingolipid hyperaccumulation
-neurodegenerative

A

Tay-Sachs Disease

44
Q

is an inherited disorder that results from the build-up of a particular type of fat called GLOBOTRIAOSYLCERAMIDE in the body’s cell

A

Fabry disease

45
Q

hypochylomicronemia
chylomicron retention disease
Apo B-48 defect leading to fat malabsorption
-absence of vit. E

A

Anderson’s disease

46
Q

sphingomyelinase deficiency
predominant among the Ashkenazi jews

A

Nieman-pick disease

47
Q

fish eye disease
presence of LP X

A

LCAT Deficiency

48
Q

childhood high serum LDL-C

A

SITOSTEROLEMIA

49
Q

Accessory enzyme that converts diacylglycerol to TAG by adding one fatty acid

A

DGAT deficiency

50
Q

most common, use if not specified
- unsuitable for non-fasting samples that contain CM or samples of B-VLDL

A

friedewald

51
Q

plasma conc. of B-100

A

80-100

52
Q

plasma conc. of E

A

3-6

53
Q

plasma conc. of A-I

A

90-130

54
Q

specific and sensitive marker for cholestasis

A

LP X

55
Q

hydrophilic lipids present on surface of LPP

A

free-cholesterol
phospholipids

56
Q

hydrophobic lipids present on the core of LPP

A

cholesterol ester
triglyceride

57
Q

lipid transport and clearance depends on

A

apolipoprotein conc.
lipid diet

58
Q

produced by liver, part of HDL
-alternative pathway for HDL metabolism

A

CETP (cholesterol ester transport protein)

59
Q

deficiency of CETP leads to the production of __

A

large cholesterol laden HDL

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