CC LIPOPROTEINS

Question 1

is absorbed by CM and delivered by VLDL and LDL

Answer 1

vit. E

Question 2

does not require CM for absorption

Answer 2

vit. D

Question 3

independent from lipoproteins

Answer 3

vit. A, K

Question 4

proteins responsible for solubility of lipids in blood
- structural integrity of lipoproteins

Answer 4

apolipoproteins

Question 5

plasma conc. of B-48

Answer 5

< 5

Question 6

efflux of cholesterol from peripheral cells towards the HDL

Answer 6

ABCA

Question 7

esterification of free cholesterol to cholesterol ester

Answer 7

LCAT

Question 8

hydrolyze TAG and phospholipids from HDL

Answer 8

endothelial lipase

Question 9

hydrolyze TAG and phospholipids from HDL, IDL, and VLDL

Answer 9

Hepatic lipase

Question 10

hydrolyze TAG and CHOLE from HDL

Answer 10

LPP LIPASE

Question 11

Most non-atherogenic LPP
largest and least dense

Answer 11

chylomicrons

Question 12

chylomicrons are completely cleared after __ hours of fasting

Answer 12

6-9 hrs

Question 13

apolipoproteins of chylomicrons

Answer 13

B-48
A-I
C
E

Question 14

reverse cholesterol transport
-cardioprotective

Answer 14

HDL

Question 14

Nascent disk-shaped particles
alpha lipoprotein
smallest most dense

Answer 14

HDL

Question 15

Atherogenic transporter of TAG
pre-beta lipoprotein
-transport endogenous TAG exported by the liver

Answer 15

VLDL

Question 16

apolipoproteins of VLDL

Answer 16

B-100
C
E

Question 17

Most atherogenic
Beta lipoprotein
measure indirectly
“most cholesterol rich”

Answer 17

LDL

Question 18

forward cholesterol transport

Answer 18

LDL

Question 19

apolipoproteins of LDL

Answer 19

B-100
E

Question 20

Product of VLDL catabolism
converted to LDL
-NOT MEASURED IN HEALTHY SERUM

Answer 20

IDL

Question 21

Found in px with obstructive jaundice and LCAT deficiency

Answer 21

LP X

Question 22

Sinking pre-beta lipoprotein
LDL-like variant
independent risk factor of atherosclerosis

Answer 22

Lp (a)

Question 23

floating beta lipoprotein
migrates abnormally in the beta regions, instead of the pre-beta region

Answer 23

B-VLDL

Question 24

Reference method for LPP quantification/ golden standard for LPP quantitative determination -using salt reagent

Answer 24

ULTRACENTRIFUGATION

Question 25

reagent used for ULTRACENTRIFUGATION

Answer 25

potassium bromide

Question 26

migration of LPP based on their protein content

Answer 26

ELECTROPHORESIS

Question 27

lipid staining dyes

Answer 27

oil red 0 fat red 7B sudan black B

Question 28

preferred support medium for electrophoresis

Answer 28

barbital/veronal

Question 29

enzymatic tests coupled with detergent precipitation is the most useful LPP test

Answer 29

chemical precipitation

Question 30

most popular method for HDL

Answer 30

homogeneous HDL-C assay

Question 31

pH for barbital/veronal

Answer 31

8.6

Question 32

beta quantification running timee

Answer 32

18 hours

Question 33

test for lipoproteins that needs fasting

Answer 33

LDL-C TAG

Question 34

test for lipoproteins that doesn't need fasting

Answer 34

HDL-C TC

Question 35

fluid of choice in routine clin lab

Answer 35

SST SERUM

Question 36

lipoprotein lipase enzyme deficiency TAG= 10,000 MG/DL (always milky despite over fasting)

Answer 36

type 1 hyperchylomicronemia

Question 37

LDL receptor defect

Answer 37

type 2a hypercholesterolemia

Question 38

Dysbetalipoproteinemia -presence of B-VLDL and IDL

Answer 38

type 3a hyperlipoproteinemia

Question 39

yellowish deposits of cholesterol under the skin, usually present around the eyelids

Answer 39

xanthelasma

Question 40

Apo B synthesis defect aka Bassen-kornzweig syndrome -presence of acanthocytosis in the blood

Answer 40

Abetalipoproteinemia

Question 41

no HDL produced at chromosome 9 there is no presence of of ABCA 1 gene

Answer 41

Tanger's disease

Question 42

B-glucocerebrosidase deficiency -most common cause of lipidosis

Answer 42

Gaucher's disease

Question 43

Hexosaminidase deficiency - sphingolipid hyperaccumulation -neurodegenerative

Answer 43

Tay-Sachs Disease

Question 44

is an inherited disorder that results from the build-up of a particular type of fat called GLOBOTRIAOSYLCERAMIDE in the body's cell

Answer 44

Fabry disease

Question 45

hypochylomicronemia chylomicron retention disease Apo B-48 defect leading to fat malabsorption -absence of vit. E

Answer 45

Anderson's disease

Question 46

sphingomyelinase deficiency predominant among the Ashkenazi jews

Answer 46

Nieman-pick disease

Question 47

fish eye disease presence of LP X

Answer 47

LCAT Deficiency

Question 48

childhood high serum LDL-C

Answer 48

SITOSTEROLEMIA

Question 49

Accessory enzyme that converts diacylglycerol to TAG by adding one fatty acid

Answer 49

DGAT deficiency

Question 50

most common, use if not specified - unsuitable for non-fasting samples that contain CM or samples of B-VLDL

Answer 50

friedewald

Question 51

plasma conc. of B-100

Answer 51

80-100

Question 52

plasma conc. of E

Answer 52

3-6

Question 53

plasma conc. of A-I

Answer 53

90-130

Question 54

specific and sensitive marker for cholestasis

Answer 54

LP X

Question 55

hydrophilic lipids present on surface of LPP

Answer 55

free-cholesterol phospholipids

Question 56

hydrophobic lipids present on the core of LPP

Answer 56

cholesterol ester triglyceride

Question 57

lipid transport and clearance depends on

Answer 57

apolipoprotein conc. lipid diet

Question 58

produced by liver, part of HDL -alternative pathway for HDL metabolism

Answer 58

CETP (cholesterol ester transport protein)

Question 59

deficiency of CETP leads to the production of __

Answer 59

large cholesterol laden HDL