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CC > CC DAY-3 PROTEINS > Flashcards

CC DAY-3 PROTEINS Flashcards

1
Q

macromolecules made of amino acids, with each amino being linked to another via a peptide bond

A

proteins

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2
Q

formed when carboxyl group of one amino acid links to the amino group of another amino acid

A

peptide bond

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3
Q

end of protein structure with a free amino group

A

n-terminal

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4
Q

end of protein structure with a free carboxyl group

A

c-terminal

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5
Q

what is the nitrogen content of proteins

A

16%

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6
Q

a balance between anabolism and catabolism

A

nitrogen balance

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7
Q

it is composed of protein (apoprotein) abd nonprotein (prosthetic group) components

A

conjugated proteins

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8
Q

polypeptides composed of only amino acids

A

simple proteins

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9
Q

protein responsible for water balance

A

albumin

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10
Q

indicator of malnutrition

A

prealbumin/transthyretin

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11
Q

landmark to confirm specimen is CSF

A

prealbumin/transthyretin

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12
Q

Transports thyroxine and retinol by binding retinol binding protein

A

prealbumin/transthyretin

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13
Q

Half life of prealbumin/transthyretin

A

1-2 days

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14
Q

sensitive to acute malnutrition

A

prealbumin/transthyretin

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15
Q

earlier marker of malnutrition

A

prealbumin/transthyretin

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16
Q

half life of albumin

A

18-20 days

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17
Q

sensitive to chronic malnutrition

A

albumin

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18
Q

negative APR

A

albumin
tranferrin

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18
Q

major contributor to oncotic pressure

A

albumin

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19
Q

rare autosomal recessive disorder manifested by the presence of a very low amount of circulating serum albumin

A

Analbuminemia

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20
Q

is analbuminemia congenital?

A

yes

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21
Q

presence if akbumin that has unusual molecular characteristics demonstrated by the presence of two albumin bands

A

bisalbuminemia

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22
Q

ALPHA1 GLOBULINS

Protease inhibitor 90% of a a1-globulin band

a. AAT
b. AFP
c. alpha1-acid glycoprotein
d. Gc-globulin
e. a1-lipoprotein
f. alpha1-antichynitrypsin

A

a

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23
Q

inactivates trypsin and other proteolytic enzymes

a. AAT
b. AFP
c. alpha1-acid glycoprotein
d. Gc-globulin
e. a1-lipoprotein
f. alpha1-antichynitrypsin

A

a

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24
Q

principal fetal protein

a. AAT
b. AFP
c. alpha1-acid glycoprotein
d. Gc-globulin
e. a1-lipoprotein
f. alpha1-antichynitrypsin

A

b

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25
Q

AFP is detectable in maternal blood up to ____

A

7th to 8th month of gestation

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26
Q

when AFP screening is done?

A

between 15 and 20 weeks of gestation

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27
Q

AKA: Orosomucoid

a. AAT
b. AFP
c. alpha1-acid glycoprotein
d. Gc-globulin
e. a1-lipoprotein
f. alpha1-antichynitrypsin

A

c

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28
Q

usefil diagnostic tool in neonatal bacterial infection

a. AAT
b. AFP
c. alpha1-acid glycoprotein
d. Gc-globulin
e. a1-lipoprotein
f. alpha1-antichynitrypsin

A

c

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29
Q

transports lipids

a. AAT
b. AFP
c. alpha1-acid glycoprotein
d. Gc-globulin
e. a1-lipoprotein
f. alpha1-antichynitrypsin

A

e

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30
Q

serine protease inhibitor

a. AAT
b. AFP
c. alpha1-acid glycoprotein
d. Gc-globulin
e. a1-lipoprotein
f. alpha1-antichynitrypsin

A

f

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31
Q

Vital component of amyloid deposits in the brain

a. AAT
b. AFP
c. alpha1-acid glycoprotein
d. Gc-globulin
e. a1-lipoprotein
f. alpha1-antichynitrypsin

A

f

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31
Q

positive risk for atherosclerosis

a. AAT
b. AFP
c. alpha1-acid glycoprotein
d. Gc-globulin
e. a1-lipoprotein
f. alpha1-antichynitrypsin

A

e

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32
Q

transports vitamin D and binds actin

a. AAT
b. AFP
c. alpha1-acid glycoprotein
d. Gc-globulin
e. a1-lipoprotein
f. alpha1-antichynitrypsin

A

d

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32
Q

increase in alzheimers disease

a. AAT
b. AFP
c. alpha1-acid glycoprotein
d. Gc-globulin
e. a1-lipoprotein
f. alpha1-antichynitrypsin

A

f

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32
Q

copper carrying protein with enzymatic activities

a. haptoglobin
b. ceruloplasmin
c. a2-macroglobulin

A

b

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32
Q

ALPHA 2 GLOBULINS

binds free hemoglobin to prevent urinary loss

a. haptoglobin
b. ceruloplasmin
c. a2-macroglobulin

A

a

33
Q

marker of wilsons disease

a. haptoglobin
b. ceruloplasmin
c. a2-macroglobulin

A

b

34
Q

largest non-Ig plasma protein (800,000 D)

a. haptoglobin
b. ceruloplasmin
c. a2-macroglobulin

A

C

35
Q

increase in stressful conditions

a. haptoglobin
b. ceruloplasmin
c. a2-macroglobulin

A

a

36
Q

increase in acute inflammation

a. haptoglobin
b. ceruloplasmin
c. a2-macroglobulin

A

a

37
Q

decrease in intravascular hemolysis

a. haptoglobin
b. ceruloplasmin
c. a2-macroglobulin

A

a

38
Q

decrease in malnutrition

a. haptoglobin
b. ceruloplasmin
c. a2-macroglobulin

A

b

39
Q

decrease in wilsons disease

a. haptoglobin
b. ceruloplasmin
c. a2-macroglobulin

A

b

40
Q

decrease in menkes syndrome

a. haptoglobin
b. ceruloplasmin
c. a2-macroglobulin

A

b

41
Q

increase in neprothic syndrome

a. haptoglobin
b. ceruloplasmin
c. a2-macroglobulin

A

c

42
Q

BETA GLOBULINS

transports lipids (VLDL)

a.pre-b-lipoprotein
b. b-lipoprotein
c. transferrin
d. hemopexin
e. B2-microglobulin
f.Complement
g.fibrinogen
h. C-reactive protein

A

a

43
Q

BETA GLOBULINS

transports lipids (LDL)

a.pre-b-lipoprotein
b. b-lipoprotein
c. transferrin
d. hemopexin
e. B2-microglobulin
f.Complement
g.fibrinogen
h. C-reactive protein

A

b

44
Q

BETA GLOBULINS

binds free ferric iron

a.pre-b-lipoprotein
b. b-lipoprotein
c. transferrin
d. hemopexin
e. B2-microglobulin
f.Complement
g.fibrinogen
h. C-reactive protein

A

c

45
Q

BETA GLOBULINS

binds free Heme

a.pre-b-lipoprotein
b. b-lipoprotein
c. transferrin
d. hemopexin
e. B2-microglobulin
f.Complement
g.fibrinogen
h. C-reactive protein

A

d

46
Q

BETA GLOBULINS

single polypeptide chain that is a components of the light chain of HLA Class 1

a.pre-b-lipoprotein
b. b-lipoprotein
c. transferrin
d. hemopexin
e. B2-microglobulin
f.Complement
g.fibrinogen
h. C-reactive protein

A

e

47
Q

BETA GLOBULINS

freely filtered by the glomerulus and completely reabsorbed

a.pre-b-lipoprotein
b. b-lipoprotein
c. transferrin
d. hemopexin
e. B2-microglobulin
f.Complement
g.fibrinogen
h. C-reactive protein

A

e

47
Q

BETA GLOBULINS

precursor of fibrin clot

a.pre-b-lipoprotein
b. b-lipoprotein
c. transferrin
d. hemopexin
e. B2-microglobulin
f.Complement
g.fibrinogen
h. C-reactive protein

A

g

48
Q

BETA GLOBULINS

Cardiac marker and inflammatory marker

a.pre-b-lipoprotein
b. b-lipoprotein
c. transferrin
d. hemopexin
e. B2-microglobulin
f.Complement
g.fibrinogen
h. C-reactive protein

A

h

48
Q

BETA GLOBULINS

primary APR

a.pre-b-lipoprotein
b. b-lipoprotein
c. transferrin
d. hemopexin
e. B2-microglobulin
f.Complement
g.fibrinogen
h. C-reactive protein

A

H

49
Q

NON-INVASIVE PROCEDURE USING VAGINAL SECRETIONS TO DETECT THREATENED ABORTION

A

B-HCG

49
Q

gamma globulins

A

immunoglobulins

50
Q
A
51
Q
A
52
Q

Oxygen carrier in muscles

A

myoglobin

53
Q

earliest cardiac marker but non specific

A

myoglobin

54
Q

most specific cardiac marker

A

toponin

55
Q

placental adeherence to the uterus and increase in preterm labor and delivery

A

fetal fibronectin

56
Q

plasma protein that is also a marker for nutritional status

A

fibronectin

57
Q

marker of bone resorption

A

cross-linked c-telopeptides

58
Q

B-trace protein AKA:

A

Prostaglandin D synthase

59
Q

Marker for CSF leakage

A
60
Q

indirect measure of GFR

A

Cystatin-C

61
Q

direct measure of GFR

A

Inulin

62
Q

marker of obesity (decrease)

A

adiponectin

63
Q
A
63
Q
A
64
Q

increase alpha 1 and alpha 2

a. acute inflammation
b. chronic infection
c. cirrhosis
d. monoclonal gammopathy
e. nephrotic syndrome
f. alpha-1-antitrypsin deficiency

A

a

65
Q

increase alpha 1, alpha 2, gamma

a. acute inflammation
b. chronic infection
c. cirrhosis
d. monoclonal gammopathy
e. nephrotic syndrome
f. alpha-1-antitrypsin deficiency

A

b

66
Q

beta gamma bridging

a. acute inflammation
b. chronic infection
c. cirrhosis
d. monoclonal gammopathy
e. nephrotic syndrome
f. alpha-1-antitrypsin deficiency

A

c

67
Q

M spike

a. acute inflammation
b. chronic infection
c. cirrhosis
d. monoclonal gammopathy
e. nephrotic syndrome
f. alpha-1-antitrypsin deficiency

A

d

68
Q

decrease albulin, increase alpha 2

a. acute inflammation
b. chronic infection
c. cirrhosis
d. monoclonal gammopathy
e. nephrotic syndrome
f. alpha-1-antitrypsin deficiency

A

e

69
Q

decrease alpha 1

a. acute inflammation
b. chronic infection
c. cirrhosis
d. monoclonal gammopathy
e. nephrotic syndrome
f. alpha-1-antitrypsin deficiency

A

f

70
Q

albumin:globulin ratio

A

2:1

71
Q

Reference method for measuring proteins

A

Kjeldahl

72
Q

method for protein:

measurement of refractive index

A

refractometry

73
Q

What method is recommended for measuring total protein

A

biuret

73
Q

reagents used in salt precipitation (methods for albumin

A

sodium sulfate, sodium sulfite, ammonium sulfate, and methanol

73
Q

method for protein:

formation of voilet colored chelate between cuprous ions and peptide bonds

A

Biuret

73
Q

METHOD OF MEASURING ALBUMIN

A

salt precipitation

74
Q

non-specific dye for albumin

A

methyl orange

75
Q

specific for albumin but subject to interferences

A

HABA

76
Q

interferences in HABA

A

Hemolysis-increase
Heparin-increase
Bilirubin-decrease
Salicylates-slight dec

76
Q

Sensitive, most commonly used dye binding for albumin

A

BCG- Bromcresol Green

77
Q

absorbs strongly below 500 nm with additional maximum absorbance at 630 nm

A

BCG- Bromcresol Green

78
Q

specific and precise

A

BCP- Bromcresol Purple

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