CbD - Organic synthesis Flashcards
What do chemists use synthesis routes for?
To get from one compound to another
Why is it vital that chemists have to be able to make one compound from another?
It is vital for things like designing medicines and making imitation of useful natural substances when the real things are hard to extract.
What do you need to include if you are asked how to make one compound from another in the exam?
1) Any special procedures, such as refluxing.
2) The conditions needed, e.g. high temperature or pressure, or the presence of a catalyst.
3) Any safety precautions, e.g. do it in a fume cupboard.
How do you get from a primary amine to an N-substituted amide? (Reaction conditions)
Acyl chloride
How do you get from an alkane to a bromoalkane? (Reaction conditions)
Br2
UV light
How do you get from a bromoalkane to a primary amine? (Reaction conditions)
NH3/excess ethanoic NH3
Reflux
How do you get from a bromoalkane to a primary alcohol? (Reaction conditions)
NaOH (aq)
Reflux (primary bromoalkanes)
How do you get from a bromoalkane to a secondary alcohol? (Reaction conditions)
NaOH (aq)
Reflux (secondary bromoalkanes)
How do you get from an alkene to a bromoalkane? (Reaction conditions)
HBr
20 degrees
How do you get from an alkene to a dibromoalkane? (Reaction conditions)
Br2
20 degrees
How do you get from an alkene to an alkane? (Reaction conditions)
Ni catalyst
150 degrees
Pressure
How do you get from an alkene to a primary alcohol? (Reaction conditions)
H2SO4 catalyst
Cold H2O
OR
H3PO4 catalyst
Steam
300 degrees
How do you get from a primary alcohol to an alkene? (Reaction conditions)
Conc. H2SO4
170 degrees
Reflux
How do you get from a primary alcohol to an aldehyde? (Reaction conditions)
K2Cr2O7
H2SO4
Heat then distil
How do you get from an aldehyde to a cyanohydrin? (Reaction conditions)
HCN
