Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Genetics and Neoplasia > CBCL 5 Pre-work > Flashcards

CBCL 5 Pre-work Flashcards

You may prefer our related Brainscape-certified flashcards:
Biology 101 flashcards
1
Q

The action of which of following proteins can suppress cancer metastasis?

  1. KRas
  2. p53
  3. Myc
  4. β-catenin
A
  1. p53
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

A palliative measure for patients with ovarian cancer and debilitating ascites is to drain the ascites directly into the venous circulation. Despite this, investigators rarely if ever observe pulmonary metastases on post-mortem examination. This observation supports which of the following notions regarding the mechanisms of metastasis?

  1. Seed and soil hypothesis
  2. Involvement of cancer stem cells
  3. Involvement of epithelial-mesenchymal transition
  4. Critical need for angiogenesis
A

Seed and soil hypothesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Which of following is a typical property of cancer stem cells?

  1. Rapid proliferation
  2. Self-renewability
  3. Sensitivity to chemotherapy
  4. Low metastatic potential
A

Self-renewability

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Millions of circulating tumor cells are routinely found in the circulation. If the patient does not develop metastases, the inability of these cells to perform which of the following actions might be responsible.

  1. Transformation
  2. Motility
  3. Invasion
  4. Extravasation
A
  1. Extravasation
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Following surgical resection of a hepatocellular carcinoma with a primary tumor 3 cm in diameter, tumors were also found in lymph nodes surrounding the liver. No distant metastasis was found. Which of following is appropriate to describe the clinical staging of this patient’s tumor?

  1. T2N1M0
  2. T0N1M0
  3. T1N1M1
  4. T4N1M0
A
  1. T2N1M0
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Which of following is a typical feature of the epithelial-to-mesenchymal transition (EMT)?

  1. Gain of baso-apical polarity
  2. Decreased potential of invasion
  3. Increased expression of transcription factors, Snail and Twist
  4. Increased cell-cell junctions
A

Increased expression of transcription factors, Snail and Twist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Which of following is considered to be a major factor influencing the specific sites of metastasis?

  1. Gender
  2. Specific hormone receptor expression on cancer cells
  3. Immune cells recruited to the primary tumors
  4. Blood flow characteristics and the structure of the vascular system
A
  1. Blood flow characteristics and the structure of the vascular system
How well did you know this?
1
Not at all
2
3
4
5
Perfectly

Genetics and Neoplasia (35 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions