Case Study/Guest Lectures

Question 1

Give a few reasons on the plaintiff’s side

Answer 1

poor material selection, conflict of interest, poor fit and customization

Question 2

Give a few reasons on the defendant’s side

Answer 2

Normal wear and tear, FDA approved, screening by doctor, patients may not follow instructions, infection, reliable materials over time.

Question 3

Ceramics in Orthopedic Implants:

Answer 3

AlO3, HA, Tricalcium Phosphate. Good for wear rate and strength, also osteophilic, but brittle.

Question 4

Metals in Orthopedic Implants:

Answer 4

Stainless Steel, Cobalt Chrome, and Titanium Alloy

Question 5

Which is stronger, cast or forged?

Answer 5

forging is much stronger and homogeneous, but more expensive.

Question 6

Polymers in Orthopedic Implants

Answer 6

PMMA (bone cement), and UHMWPE.

Question 7

3 Major Positives to Nanocarriers

Answer 7

1) can enhance drug solubility or prevent early degradation.
2) Controlled drug release kinetics
3) Tissue targeting.

Question 8

What are 3 things necessary for cell cultures?

Answer 8

Fetal bovine/calf serum–growth hormones–proteins to allow adsorption–Ca2+ and Mg2+.

Question 9

RGD: contains which proteins? (6)

Answer 9

fibronectin, vitronectin, laminin, cell adhesion molecules, collagen, gelatin etc.