Biodegradable Materials Flashcards
What is another way that you can alter your release kinetics?
Surface area, screw shape example.
What are some ways that a biodegradable material can be useful as a component?
Biodegradable element can be used as a temporary scaffold such as a suture or fixation, or a barrier, for example between healing tissues. It can also be used as a drug delivery matrix.
What is the increasing rate of biodegradation between ethers, ketones,esters, and anhydrides?
Ethers, ketones, esters, then anhydrides are most biodegradable.
Name 5 material parameters that you could alter degradation rate
Chemical bonds, different copolymer compositions, device geometry.. Hydrophilicity, and ? Crystallinity, anisotropic, resistance to known enzymes.
What are 4 mechanisms of biodegradation?
Solubilization, charge formation, chemical hydrolysis, enzymes
Bulk erosion
Water penetration is faster than rate of polymer transformation into water soluble materials. (Alkezelter tablets)
Surface erosion
Water penetration is slower than material transformation into water soluble materials. Shape and integrity maintained. Thinning
Biodegradable definitions: biodegradation
material converts to less complex components via hydrolysis or enzymes etc.
Biodegradable definitions: bioresorption
degradation and elimination via NATURAL PATHWAYS
Biodegradable definitions: bioadsorption
material degrades via normal metabolism
biodegradable definitions: bioerosion
water insoluble material converted to water soluble material
biodegradable definitions: biodeterioration
degrading in an undesirable way
special PGA polymer
makes hydrophobic compounds more water soluble, can reduce immunogenicity, hydrodynamic radius of compound increased.
