CASE PRESENTATION STUDY Flashcards
What is hypertension?
High blood pressure
What are some known risk factors for development of hypertension?
- age (older)
- obesity
- family history
- tobacco
- poor diet
- alcohol
- genetics
How is hypertension graded?
Graded using the NICE definition
- Stage 1 (mild)
- Stage 2 (moderate)
- Stage 3 (severe)
What are the measurements that classify “mild” hypertension?
Systolic = 140-159mmHg
Diastolic = 90-99mmHg
What are the measurements that classify “moderate” hypertension?
Systolic = 160-179mmHg
Diastolic = 100-109mmHg
What are the measurements that classify “severe” hypertension?
Systolic = 180mmHg or higher
Diastolic = 110mmHg or higher
What readings would be considered hypertensive crisis?
Systolic = 180mmHg+
Diastolic = 120mmHg+
How severe is your patients hypertension?
Mild according to pt
What are the symptoms of hypertension?
- Often none
- Headache (especially in the morning)
- Nosebleeds
- Blurred vision
- Shortness of breath
What medications can be used to treat hypertension?
- beta blockers
- ACE inhibitors
- diuretics
- calcium channel blockers
- ARB (angiotensin II receptor blocker)
What type of drug is Candesartan?
Angiotensin II receptor blocker
How does Candesartan work?
- Blocks angiotensin II type 1 receptors (located on blood vessels)
- blocks the effects of Angiotensin II such as vasoconstriction and aldosterone secretion (hormone that promotes salt & water retention)
- Both of these lead to reduced blood pressure
What are potential side effects of Candesartan?
- Dizziness and lightheaded
- Postural hypotension
- Fatigue
- Nausea
- Diarrhoea
Why is cataract surgery indicated?
Clouding of the eye causing visual impairment. Occurs due to:
- aging
- genetics
- trauma
- medical conditions (eg diabetes)
- long term use of corticosteroids
What is a detached retina?
the retina (light sensitive layer of tissue at back of eye) becomes separated from underlying connective tissues
- leads to severe visual impairment
How might a detached retina affect his dental history?
Poor central vision in right eye =
- difficulty with OH
- progressive loss of vision
What is the mechanism of action of statins?
Used to lower cholesterol levels in the body
- inhibits the HMG-CoA reductase enzyme
- this enzyme plays a crucial role in the synthesis pathway of cholesterol in the liver
- therefor a reduction in liver production of cholesterol
- liver increases expression of LDL receptors, so LDL cholesterol is cleared from bloodstream quicker
What are the clinical benefits associated with statins?
reduction in production of atherosclerotic plaques therefor reduced CV risk
Common statins:
- atorvastatin
- simvastatin
Side effects of statins:
- liver function changes
- increased blood sugar [risk of developing type 2 diabetes] in some individuals
- drug interactions
Statin effects on dental tx?
- Liver function changes so be careful when using LA metabolised in liver if this is the case (eg Lidocaine)
- Xerostomia leading to higher caries risk
- Interactions with Azole antifungals so need to be careful
What medications do statins interfere with?
- “Azole” antifungals
- Clarithromycin
- Phenytoin
- Warfarin (mess up the INR level)
How can cadasartan interfere with dental tx?
- Orthostatic/postural hypotension due to low BP
- Xerostomia
- Interaction with NSAIDs [they reduce the effect of Candesartan]
What allergy does your patient suffer from?
Allergy to ibuprofen
Discuss ibuprofen allergy:
Drug hypersensitivity reaction
What are symptoms of ibuprofen allergy?
- Skin reactions = hives, itching, redness
- Respiratory = shortness of breath, wheezing coughing
- Angioedema = lip/face/throat swelling
- GI = vomiting, nausea, diarrhoea, abdominal pain
How might an ibuprofen allergy be diagnosed?
- Skin testing/patch testing
- Drug challenge test
What type of hypersensitivity reaction is an ibuprofen allergy?
Can be:
- Type I (immediate hypersensitivity) *** most common
- Type III (immune complex)
- Type IV (delayed hypersensitivity)
What is the mechanism of Type I hypersensitivity reaction?
- mediated by immunoglobin IgE antibodies
- when exposed to the allergen (ibuprofen), IgE binds to mast cells and basophils
- leads to the release of histamine and inflammatory products
What are the clinical presentations of a Type I hypersensitivity reaction?
- hives
- angioedema
- respiratory symptoms
- anaphylaxis
What is anaphylaxis?
severe and life-threatening allergy condition
How many sugar intakes per day makes someone high caries risk?
3+ sugar intakes per day at separate times
What effect does smoking have on general health?
Smoking can lead to:
- respiratory diseases (COPD, cancer)
- CV disease (atherosclerosis, stroke, heart attack)
- cancer (lung, throat, oral, stomach)
- reduced immune function
- lowered reproductive health
What effect does smoking have on oral health?
Increased risk of
- Periodontal disease
- Oral cancer
- Delayed healing
- Halitosis and tooth staining
- Chronic hyperplastic candidosis
-
How does smoking increase periodontal disease risk?
- Vasoconstriction of gingival tissues (reduction in oxygen & nutrients to gingiva)
- Impaired chemotaxis of neutrophils/macrophages to fight off periodontal causing bacteria
- Increased osteoclast activity leading to bone resorption
- Impaired wound healing & collagen production
What bacteria are involved in periodontal disease?
- P. gingivalis
- Prevotella intermedia
How much more likely are you to develop oral cancer if you smoke? (no alc)
2x more likely (increases with frequency and consumption)
How much more likely are you to develop oral cancer if you drink alcohol?
2x more likely
How much more likely are you to develop oral cancer if you smoke AND drink alcohol?
5x more likely (synergistic effect)