Case Based - Fitz Flashcards
What is the mechanism of action for Bortezomib?
5) Target Altered Processes
i) Inhibit 26S Proteosome (B-cells)
Increase Ubiquitination –> apoptosis
What drug class does Bortezomib belong to, cell cycle specifics and side effects?
Monoclonal Antibody
Antineoplastic
CCS - G2/M
Reactivation of VZV or HBV
What is the mechanism of action for Lenalidomide/Thalidomide?
6) Prevent Angiogenesis (decrease VEGF)
Selectively inhibits secretion of pro-inflammatory cytokines (anti TNF-alpha)
What is drug class for Lenalidomide/Thalidomide cell cycle specific and side effects?
CCNS
ALL, Hodgkins, B-cell lymphoma, myelofibrosis
What is the MOA of IL-2?
4) Immune System Modulators
B) Immune Stimulators - Cytokine
Induces/expands T-cell response
What is the MOA of Prednisone?
4) Immune System Modulators
A) Immunosuppressive Glucocorticoid
Glucocorticoid Receptor Agonist
Blocks Phospholipase 2 and COX
Prevents inflammation by blocking production of leukotrienes and prostaglandinsWhat is the MOA of Melphalan?
2) Damaging DNA
A) Alkylating Agents - Crosslinking DNA
iv) Melphalan
What is the MOA of 6-Mercaptopurine?
1) Preventing DNA Synthesis
A) Block Nucleotide Synthesis
Purines
Inhibits PNP (purine nucleoside phosphorylase) and PRPP (phosphoribosyl pyrophosphate)
What is the difference between Lyphokine Activated Killer cells (LAK) and Cytokine Induced Killer cells (CIK)?
Lymphokine Activated Killer cells (LAK) - white blood cells (NK cells) that has been stimulated to kill mutant B-plasma cells
Cytokine Induced Killer cells (CIK) - immune effector cells featuring CD8+ T-cell-like phenotype
What are both LAKs and CIKs activated by?
IL-2
How are Lymphokine Activated killer cells produced compared to Cytokine Induced Killer cells?
LAK cell production - Lymphocytes cultures with IL-2 to develop NK cells that kill mutant B-Plasma cells
CIK cell production - Ex vivo mononuclear cells with IFN-gamma, anti-CD3 antibody, IL-1, and IL2
