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IHO Week 2 > Benign Leukocytoses - Krafts > Flashcards

Benign Leukocytoses - Krafts Flashcards

1
Q

Benign Leukocytoses

A

Elevation in the WBC count

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2
Q

Neutrophilia

A

Elevated neutrophil granulocytes count in the blood

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3
Q

Mature Neutrophilia Causes

A

Bacterial Infection
Inflammation
Physiologic (Stress/Hormones)

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4
Q

Immature Neutrophilia Causes

A

Bacterial Infection
Inflammation
Severe Anemia
Something filling up marrow

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5
Q

3 types of Toxic Changes seen with INFECTION:

A 
Toxic Granulation
Dohle Bodies (RER in cytoplasm)
Cytoplasmic Vacuolization (SCARY!)
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6
Q

Left Shift

A

Increase in the number of immature leukocytes, specifically band cells

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7
Q

Leukemoid Reaction

A

Increased WBC count (leukocytosis) as a result of infection or stress

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8
Q

Leukoerythroblastic Reaction

A

A bone marrow response in which nucleated RBCs and immature leukocytes are released
Due to something malignant
Due to something benign

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9
Q

Normal Immunophenotype in Blood

A

T-Cells: 80%
B-Cells: 15%
NK Cells: 5%

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10
Q

What age group has the highest normal lymphocyte count?

A

Infants

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11
Q

Mature Lymphocytes

A

Bunch of mature lymphocytes in the blood

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12
Q

Reactive (funny-looking) Lymphocytes

A

Become large due to antigen stimulation
AKA Downey Cells
Also see Plasmacytoid Lymphocytes

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13
Q

Mature Lymphocytosis Causes

A

Infectious Lymphocytosis
Bordatella Pertussis
Transient Stress

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14
Q

Infectious Lymphocytosis causes what?

A

The BIGGEST mature lymphocyte count (around 100)

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15
Q

Reactive Lymphocytosis Causes

A

Infectious Mononucleosis
Pediatric Viral Infections
Viral Hepatitis
Immune Disorders

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16
Q

Downey Cells

A

Common in Mononucleosis

17
Q

Left Shift

A

Toxic Changes
Fewer immature cells
No basophilia
LAP normal or increased

18
Q

Chronic Myeloid Leukemia

A

SUPER-High WBC
Lots of immature cells
Basophilia
LAP decreased

19
Q

What is the best way to differentiate Benign Neutrophilia from CML?

A

Cytogenetics looking for the Philadelphia Translocation between chromosomes 9 and 22

20
Q

What characterizes Reactive Lymphocytosis?

A

Atypical Lymphocytes

Young (under 40)

21
Q

What characterizes CLL?

A

Mature Lymphocytes that all look the same

Older (over 40)

22
Q

What characterizes Mature Lymphocytosis?

A 
Mature lymphocytes
VERY young (under 14)
23
Q

What is the best way to differentiate Benign Lymphocytosis from CLL?

A

Immunophenotyping

24
Q

What disease is basophilia ONLY seen in?

A

Chronic Myeloid Leukemia

25
Q

What are the causes of Eosinophilia?

A

Drugs
Asthma
Skin Diseases
Parasites

26
Q

What are the causes of Monocytosis?

A

Infection
Autoimmune Disease
Malignancy (Solid Tumor)

IHO Week 2 (13 decks)

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