Case 8 SBA Flashcards
What are the layers of the skin?
Cutaneous membrane and subcutaneous layer
Accessory structures of the skin
Nails, exocrine glands, hair
Layers of epidermis from deep to superficial
basale, spinosum, granulosum, lucidum (thick only), corneum
Surface epithelium of epidermis
Keratinised stratified squamous
What are the layers of the epidermis made of?
Keratin
Stratum basale
divides to produce the rest of the layers
Stratum spinosum
spiny protrusions, attached through desmosome, variable number of layers, large amounts of cytoplasmic keratin
Stratum granulosum
differentiated, contain granules, secrete lipid layer between cells
Stratum lucidum
thick skin only, translucent, no nucleus
Stratum corneum
thickest layer, continually shedding
What do keratinocytes undergo instead of apoptosis?
Cornification
Specialised cells in the epidermis
Melanocytes, langerhans, merkel cells
Describe melanocytes
specialised cells responsible for pigmentation. Have cytoplasmic projections that transfer melanin granules into keratinocytes. Melanocytes cover the nucleus of cells with melanin to protect from UV rays.
Describe langerhans cells
phagocytes that migrate to lymph nodes when activated
Describe Merkel cells
in the basal layer, responsible for fine touch and pressure sensing, high density in thick skin and lips