Case 8 SBA Flashcards

1
Q

What are the layers of the skin?

A

Cutaneous membrane and subcutaneous layer

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2
Q

Accessory structures of the skin

A

Nails, exocrine glands, hair

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3
Q

Layers of epidermis from deep to superficial

A

basale, spinosum, granulosum, lucidum (thick only), corneum

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4
Q

Surface epithelium of epidermis

A

Keratinised stratified squamous

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5
Q

What are the layers of the epidermis made of?

A

Keratin

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6
Q

Stratum basale

A

divides to produce the rest of the layers

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7
Q

Stratum spinosum

A

spiny protrusions, attached through desmosome, variable number of layers, large amounts of cytoplasmic keratin

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8
Q

Stratum granulosum

A

differentiated, contain granules, secrete lipid layer between cells

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9
Q

Stratum lucidum

A

thick skin only, translucent, no nucleus

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10
Q

Stratum corneum

A

thickest layer, continually shedding

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11
Q

What do keratinocytes undergo instead of apoptosis?

A

Cornification

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12
Q

Specialised cells in the epidermis

A

Melanocytes, langerhans, merkel cells

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13
Q

Describe melanocytes

A

specialised cells responsible for pigmentation. Have cytoplasmic projections that transfer melanin granules into keratinocytes. Melanocytes cover the nucleus of cells with melanin to protect from UV rays.

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14
Q

Describe langerhans cells

A

phagocytes that migrate to lymph nodes when activated

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15
Q

Describe Merkel cells

A

in the basal layer, responsible for fine touch and pressure sensing, high density in thick skin and lips

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16
Q

Describe papillary layer of dermis

A

made of collagen, projects into stratum basale of epidermis to form finger-like dermal papillae which form epidermal/papillary ridges which in turn form fingerprints

17
Q

What does the papillary layer of skin contain?

A

fibroblasts, adipocytes, blood vessels, phagocytes, lymphatic capillaries, nerve fibres, and Meissner corpuscles (touch sensors)

18
Q

Describe reticular layer of dermis

A

much thicker than papillary layer, composed of dense irregular connective tissue (collagen and elastin), well vascularised, rich sensory and sympathetic nerve supply.

19
Q

Describe hypodermis

A

well-vascularised, loose areolar connective tissue and adipose tissue that provides insulation and cushioning. Connects skin to underlying fascia of bones and muscles.

20
Q

Terminal hair

A

pigmented and coarse, found on head, armpits, and groin

21
Q

Vellus hair

A

fine and unpigmented, found everywhere else on the body except for palms of hands and soles of feet.

22
Q

Lanugo hair

A

fine and pigmented, normally only found on new-borns, but is also seen on the arms/back of people with anorexia as a response to disrupted thermoregulation in an attempt to insulate the body

23
Q

Structure of hair

A

made of keratinised epithelial cells. Consist of a follicle (the living part under the skin’s surface) and hair shaft which is outside.

24
Q

Describe hair matrix

A

The hair matrix, containing the proliferating cells that generate the hair and internal root sheath, is found just above the dermal papilla and is separated from it by a basement membrane. The cells in the matrix proliferate and move upwards, gradually becoming keratinised to produce the hair

25
Q

Structures associated with hair

A

sebaceous glands, arrector pili muscles, and apocrine sweat glands, dermal papilla contains blood supply at base of follicle

26
Q

Layers of the hair matrix

A

From external to internal: outer root sheath, inner root sheath, cuticle (flattened squamous), cortex (compressed cuboidal) and medulla.

27
Q

Functions of hair

A

thermoregulation, protection, sensory input, and cosmetic/social aspects

28
Q

Hair growth phases

A

anagen, catagen, telogen, hair falls out, return to anagen

29
Q

Anagen phase

A

active growth phase, mitosis of matrix cells, lasts 2-6 years

30
Q

Catagen phase

A

regressing/transition phase, lasts 1-2 weeks

31
Q

Telogen phase

A

resting phase, dermal papilla separated from follicle, lasts 5-6 weeks

32
Q

Hair loss

A

anagen hairs is usually due to drugs e.g. chemotherapy – left with wispy telogen hairs until they fall out max. three months later.
Loss of telogen hairs usually after severe illness – left with bald patches.

33
Q

Pilo-sebaceous unit

A

made of hair, arrector pili muscle, and sebaceous gland

34
Q

Describe arrector pili muscle

A

small smooth muscle that connects obliquely to upper dermis and base of follicle, sympathetic innervation, contraction of muscles causes hairs to stand up, squeezes sebaceous gland so sebum is released to protect the hair

35
Q

Describe sebaceous gland

A

produces sebum in a holocrine process

36
Q

Holocrine process of sebaceous gland

A

cells rupture and disintegrate as they release sebum

37
Q

Describe sebum

A

lipid and oil rich, waterproofs and lubricates