Case 3 SBA Flashcards
Divisions of the peritoneal cavity
Greater and lesser sac
Greater sac of peritoneal cavity
Starts at diaphragm and descends into pelvic cavity. Is not contained by the reflections
Lesser sac of peritoneal cavity
Lies behind stomach and liver, contained by reflections
Lesser omentum
Connects liver to curvature of the stomach
Medial part of lesser omentum
Hepatogastric ligament
Lateral part of lesser omentum
Hepatoduodenal ligament
Greater omentum
Connects greater curvature of stomach to transverse colon
The mesentery
Anchors small intestine to abdominal wall
Other examples of mesenteries
Mesocolon, sigmoid mesocolon, mesoappendix
Lienorenal ligament
Connects spleen and kidney
Omentum definition
reflection between two organs
Mesentery definition
reflection between organ and posterior abdominal wall
Retroperitoneal organs
Only covered on anterior surface by peritoneum. SADPUCKER (suprarenal glands, aorta, duodenum, pancreas, ureters, colon, kidneys, oesophagus, rectum)
Supra-colic organs
Stomach, liver, gallbladder, spleen
Infra-colic organs
Small intestine, transverse colon, sigmoid colon
Falciform ligament of liver
Attaches to anterior abdominal wall. Becomes coronary ligaments.
Coronary ligaments of liver
Attach liver to diaphragm, meet and form triangular ligament
Main muscles of the posterior abdominal wall
Quadratus lumborum, psoas, ilacus
Sections of the male urethra
pre-prostatic, prostatic, membranous, and spongy
Male vs female urethra length
20cm vs 5cm
Kidney drainage route
papilla → minor calyx → major calyx → renal pelvis → ureter
Which kidney is the most inferior?
Right
What crosses the left renal vein anteriorly?
Superior mesenteric
What connects the supra and infra-colic compartments of the greater sac?
Paracolic gutters
Clinical implications of paracolic gutters
More common to have infection on right side that can spread upwards towards the right subphrenic space (between diaphragm and liver)
Subphrenic abscess
Accumulation of pus in subphrenic space
Definition of chronic kidney disease
Longstanding abnormal kidney function or structure with GFR < 60 mls/min/1.73m^2
Stage 1 CKD
Haematuria, proteinuria, abnormal anatomy, normal GFR > 90
Stage 2 CKD
Haematuria, proteinuria, abnormal anatomy, mildly reduced GFR (60-89)
Stage 3 CKD
Moderately reduced GFR (30-59)
Stage 4 CKD
Severe reduction in GFR (15-29)
Stage 5 CKD
Kidney failure, GFR <15
Level A1 kidney disease
Albuminuria <3mg/mmol
Level A2 kidney disease
Albuminuria 3-30 mg/mmol
Level A3 kidney disease
Albuminuria >30 mg/mmol
Cause of urinary tract infections
Bacteria enter urinary tract, adhere to bladder cells, and elicit inflammatory response
Top two causes of UTIs
E-coli and staphylococcus aureus
Lower UTI
infection confined to bladder and urethra
Upper UTI
infection spreads to kidney and ureter. more severe
Complicated UTI
Other condition (including diabetes, kidney stones, blockages, catheters, immunosuppressants, and developmental abnormalities) along with UTI. Higher risk of kidney damage and septicaemia
Risk factors for UTIs
female gender, increasing age, recent antibiotic use, recent sexual activity, catheterisation, pregnancy, institutionalisation, diabetes
Signs/symptoms of lower UTI
increased urinary frequency (polyuria), painful urination (dysuria), haematuria (most common cause of haematuria is UTI), foul-smelling or cloudy urine (pyuria), urgency, urinary incontinence
Signs/symptoms of upper UTI
rigors, fever (pyrexia), nausea/vomiting, flank pain, confusion in elderly patients
Bacteria in urine but no UTI symptoms
asymptomatic bacteriuria
UTI epidemiology
UTIs uncommon in men and children. 25% of women will experience UTIs, and 25% of these will have recurrent UTIs. In men and children, usually have an underlying abnormality of the urinary tract. Presents with confusion in elderly people with an upper UTI
Urine changes with UTI
pyuria, dysuria, haematuria, polyuria, incontinence, urgency, very small amounts produced.
Urine changes in AKI
reduced urine output
Urine changes in CKD
increased frequency
Describe loop diuretics
act on thick ascending loop of Henle, are powerful diuretics. Inhibit Na-K-2Cl channels. Increase Na excretions and hyperosmolarity of filtrate
Loop diuretic examples
Furosemide and bumetanide
Thiazide-like diuretics examples
Chlorthalidone, indapamide, hydrochlorothiazide
Potassium sparing diuretics mechanisms
mineralocorticoid receptor blockers (aldosterone antagonists) or ENaC blockers
Aldosterone antagonist examples
Spironolactone and eplerenone
ENaC blockers examples
Amiloride and triamterene
Proximal tubule handling of potassium
Paracellular reabsorption
Loop of Henle handling of potassium
Reabsorption primarily via Na/K/2Cl cotransporters
Principal cells in DCT and CD handling of potassium
excrete K following Na reabsorption
Alpha-intercalated cells in CD handling of potassium
reabsorb K in exchange for H
What dictates the net effect of potassium handling?
Relative handling by principal and alpha-intercalated cells
Sodium reabsorption in PCT
apical surface has Na/K ATPase and Na/HCO3 symporter. Basolateral surface has Na/glucose symporter and Na/H exchanger
Sodium reabsorption in LOH
has channels for Na to move freely. Also includes Na/K/2Cl pump on apical surface and Na/K ATPase on basolateral surface
Sodium reabsorption in DCT
Na/Cl symporter on apical surface, Na/K ATPase on basolateral surface. Has Na/H exchanger and aldosterone-controlled Na/K exchanger on both surfaces
Sodium reabsorption in CD
Na/H exchanger and aldosterone-controlled Na/K exchanger on both surfaces