Cartilage Tissue - Downing Flashcards

1
Q

Bone and Cartilage Differences?

A

Bone matrix mineralizes; cartilage mineralization leads to degeneration

Cartilage is avascular; bone is vascular

Cartilage lacks innervation

Cartilage growth is appositional and interstitial; bone grows appositionally

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2
Q

Chondroblasts vs chondrocytes?

A

Chondroblasts
-Active cells

Chondrocytes
-Quiescent or relatively inactive

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3
Q

What is the space called where cartilage cells reside?

A

Lacunae

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4
Q

What makes up the cartilage matrix?

A

60-80% water
Proteoglycan aggrecan
Hyaluronic acid
(Helps form proteoglycan aggregates)

Extremely hydrophilic: binds Na+, water and produces a stiff gel

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5
Q

3 types of cartilage:

What types of collagen are each made up of?

A
Hyaline cartilage
(type 2)
Elastic cartilage
(type 2)
Fibrocartilage
(type 1)
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6
Q

Most of the fetal skeleton is laid down in what cartilage?

A

Hyaline cartilage

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7
Q

Where do you find elastic cartilage? How do you differentiate it form hyaline cartilage?

A

Location: ear-related structures, epiglottis, part of larynx

BOTH have type 2 collagen, elastic cartilage is more cellular, elastic fibers

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8
Q

How can you differentiate fibrocartilage from hyaline and elastic cartilage?

A

Linear rather than globular clumpy organization
Type 1 collagen
NO perichondrium

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9
Q

Where do you find fibrocartilage?

A

The annulus fibrosis of the intervertebral disks!

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