Cartilage Histology Articulate Flashcards

1
Q

General composition of connective tissue

A

cells + ECM

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2
Q

What is the major competent of connective tissue: cells or ECM

A

ECM

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3
Q

What gives each connective tissue type their different characteristics

A

arragement of ECM

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4
Q

ECM is composed of

A

Protein fibers and ground substance

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5
Q

Types of protein fibers in the ECM

A

Collagen
Reticular
Elastic

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6
Q

made up of Glycosaminoglycans (GAGs), Proteoglycans, and iadhesive Glycoproteins

A

Ground substance

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7
Q

hyaluronic acid and chondroitin sulfate

A

Glycosaminoglycans (GAGs)

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8
Q

laminin and fibronectin

A

Multiadhesive Glycoproteins

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9
Q

Can be fluid, semifluid, gelatinous, or calcified

A

Ground substance

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10
Q

All connective tissues are derived from the loosely organized embryonic connective tissue known as

A

Mesenchyme

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11
Q

Mesenchyme is considered to be

A

multipotent

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12
Q

what type of tissue is blood

A

connective

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13
Q

Mesenchymal cells differentiate into _____ which are cells associated with developing cartilaginous tissue

A

chondroblasts

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14
Q

Is Cartilage vascularized

A

No

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15
Q

Growth by addition to an existing surface; generation of new chondroblasts

A

Appositional Growth

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16
Q

Growth by internal expansion; proliferation of chondrocytes and formation of isogenous groups

A

Interstitial Growth

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17
Q

Mechanisms of Cartilage Growth

A

Interstitial & Appositional

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18
Q

Role is to secrete extracellular matrix

A

chondroblast

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19
Q

Role is to secrete and maintain the extracellular matrix

A

chondrocyte

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20
Q

Are found in cavities within the extracellular matrix called lacunae

A

chondrocyte

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21
Q

What percent of cartilage is the extracellular matrix

A

~95%

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22
Q

Tissue that is resilient to external pressures and has high tensile strength

A

Cartilage

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23
Q

Tissue capsule that covers most, but not all, cartilages called

A

perichondrium

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24
Q

perichondrium is made of what type of tissue

A

dense connective tissue

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25
contains blood vessels, nerves, chondrogenic cells, fibroblasts, and type I collagen fibers
perichondrium
26
essential for the growth and maintenance of the cartilage
perichondrium
27
Receive nutrients and oxygen via diffusion from blood vessels located in the perichondrium
chondrocytes in lacunae
28
What limits the growth of cartilage?
limited diffusion of ECM
29
Hyaline Cartilage, Elastic Cartilage, and Fibrocartilage are what
types of cartilage
30
The most common type of cartilage in the human body
Hyaline cartilage
31
What is the main fiber in Hyaline cartilage ECM
Type II collage
32
what does water bind to int he ECM
Negatively charged GAGs
33
What makes hyaline cartilage resilient and a great shock absorber?
Large amount of water
34
also includes proteoglycans, different GAGs such as hyaluronan, chondroitin sulfate, and keratin sulfate
Hyaline cartilage
35
can be found on articular surfaces as articular cartilage, making up the tip of the nose, and in the larynx
Hyaline cartilage
36
can be found composing tracheal rings, epiphyseal plates, and fetal bone models
Hyaline cartilage
37
perichondrium would be easily damaged at articular sites by the motion of the joints
the surface of articular cartilage
38
Why aren't collagen fibers discernible, form surrounding substances, in histological section
the same refractive index
39
What is indicative of Hyaline cartilage growing via interstitial growth
isogenous groups
40
Once the chondroblast are completely surrounded by the matrix and are stuck in a
lacuna
41
Once in a lacuna the chondroblasts name changes to
chondrocytes
42
chondrogenic cells can develop into
chondroblasts
43
In this histological H&E stained section which part of Hyaline cartilage is eosinophilic
perichondrium
44
Which layer contains the chondrogenic cells that produce chondroblasts
perichondrium
45
These cells are synthesizing and secreting extracellular matrix and allowing for the growth of the cartilage through appositional growth
chondroblasts
46
what pushes newly divided Hyaline cartilage further apart from the isogenous groups
secretion of ECM
47
Why is hyaline cartilage matrix is basophilic
GAGs
48
This matrix has just been recently secreted and is richer in GAGs and poor in collagen
territorial matrix
49
In this matrix, collagen is more abundant
interterritorial matrix
50
Which type of matrix is more basophilic?
territorial matrix
51
Why is the territorial matrix more basophilic
high concentration of GAGs
52
Indicates that the chondrocytes recently underwent mitosis
isogenous group
53
Which organelles indicate that the cells are actively engaged in the production of the extracellular matrix leading to the cartilage's interstitial growth
Golgi & RER
54
What types of fibers are in Elastic cartilage
Type II collage & elastic
55
What type of properties do Elastic fibers give elastic cartilage
pliability and resilience
56
can be found composing the auricle (pinna) of the ear, a portion of the auditory canal, the auditory (pharyngotympanic) tube, and the epiglottis
Elastic cartilage
57
is a perichondrium associated with elastic cartilage
Yes
58
In histological section, the extensive elastic fibers are visible as a dense network of
branching and anastomosing fibers
59
What type of stain has to be used for elastic cartilage
Special stain
60
elastic cartilage has a higher ratio of __________ than hyaline cartilage
chondrocytes to matrix
61
elastic cartilage has fewer cells per ______ than hyaline cartilage
isogenous group
62
you can see the large white or unilocular adipose cells in the elastic cartilage of what?
epiglottis
63
What replaces elastic cartilage in the epiglottis as people age
Adipose
64
What cartilage has less proteoglycans than other cartilages
Fibrocartilage
65
What types of fibers are in fibrocartilage
type I and II collagen
66
Found in intervertebral discs, pubic symphysis, major tendon-bone anchorages
Fibrocartilage
67
Does fibrocartilage have a perichondrium
No
68
fibrocartilage is found in areas of the body that undergo
pulling forces and compression
69
contains chondrocytes arranged in long rows, separated by course type I collagen fiber
fibrocartilage
70
fibrocartilage has fewer ________ than hyaline or elastic cartilage
chondrocytes
71
chondrocytes aligned along collagen bundles either singularly or in isogenous groups in what type of cartilage
fibrocartilage
72
Often fibrocartilage is seen next to
dense connective tissue
73
the fibrocartilage matrix is more acidophilic than the other cartilage types because of
Type I collagen
74
The type one collagen is laid down along. . .
stress lines
75
of the three different types of cartilage what defines the characteristics of each tissue
ECM composition
76
Which type of cartilage is considered to be an intermediate between hyaline cartilage and dense connective tissue?
Fibrocartilage
77
Can withstand both compression and shearing forces
Fibrocartilage