Cartilage Histology Articulate Flashcards

1
Q

General composition of connective tissue

A

cells + ECM

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2
Q

What is the major competent of connective tissue: cells or ECM

A

ECM

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3
Q

What gives each connective tissue type their different characteristics

A

arragement of ECM

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4
Q

ECM is composed of

A

Protein fibers and ground substance

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5
Q

Types of protein fibers in the ECM

A

Collagen
Reticular
Elastic

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6
Q

made up of Glycosaminoglycans (GAGs), Proteoglycans, and iadhesive Glycoproteins

A

Ground substance

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7
Q

hyaluronic acid and chondroitin sulfate

A

Glycosaminoglycans (GAGs)

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8
Q

laminin and fibronectin

A

Multiadhesive Glycoproteins

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9
Q

Can be fluid, semifluid, gelatinous, or calcified

A

Ground substance

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10
Q

All connective tissues are derived from the loosely organized embryonic connective tissue known as

A

Mesenchyme

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11
Q

Mesenchyme is considered to be

A

multipotent

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12
Q

what type of tissue is blood

A

connective

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13
Q

Mesenchymal cells differentiate into _____ which are cells associated with developing cartilaginous tissue

A

chondroblasts

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14
Q

Is Cartilage vascularized

A

No

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15
Q

Growth by addition to an existing surface; generation of new chondroblasts

A

Appositional Growth

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16
Q

Growth by internal expansion; proliferation of chondrocytes and formation of isogenous groups

A

Interstitial Growth

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17
Q

Mechanisms of Cartilage Growth

A

Interstitial & Appositional

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18
Q

Role is to secrete extracellular matrix

A

chondroblast

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19
Q

Role is to secrete and maintain the extracellular matrix

A

chondrocyte

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20
Q

Are found in cavities within the extracellular matrix called lacunae

A

chondrocyte

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21
Q

What percent of cartilage is the extracellular matrix

A

~95%

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22
Q

Tissue that is resilient to external pressures and has high tensile strength

A

Cartilage

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23
Q

Tissue capsule that covers most, but not all, cartilages called

A

perichondrium

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24
Q

perichondrium is made of what type of tissue

A

dense connective tissue

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25
Q

contains blood vessels, nerves, chondrogenic cells, fibroblasts, and type I collagen fibers

A

perichondrium

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26
Q

essential for the growth and maintenance of the cartilage

A

perichondrium

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27
Q

Receive nutrients and oxygen via diffusion from blood vessels located in the perichondrium

A

chondrocytes in lacunae

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28
Q

What limits the growth of cartilage?

A

limited diffusion of ECM

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29
Q

Hyaline Cartilage, Elastic Cartilage, and Fibrocartilage are what

A

types of cartilage

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30
Q

The most common type of cartilage in the human body

A

Hyaline cartilage

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31
Q

What is the main fiber in Hyaline cartilage ECM

A

Type II collage

32
Q

what does water bind to int he ECM

A

Negatively charged GAGs

33
Q

What makes hyaline cartilage resilient and a great shock absorber?

A

Large amount of water

34
Q

also includes proteoglycans, different GAGs such as hyaluronan, chondroitin sulfate, and keratin sulfate

A

Hyaline cartilage

35
Q

can be found on articular surfaces as articular cartilage, making up the tip of the nose, and in the larynx

A

Hyaline cartilage

36
Q

can be found composing tracheal rings, epiphyseal plates, and fetal bone models

A

Hyaline cartilage

37
Q

perichondrium would be easily damaged at articular sites by the motion of the joints

A

the surface of articular cartilage

38
Q

Why aren’t collagen fibers discernible, form surrounding substances, in histological section

A

the same refractive index

39
Q

What is indicative of Hyaline cartilage growing via interstitial growth

A

isogenous groups

40
Q

Once the chondroblast are completely surrounded by the matrix and are stuck in a

A

lacuna

41
Q

Once in a lacuna the chondroblasts name changes to

A

chondrocytes

42
Q

chondrogenic cells can develop into

A

chondroblasts

43
Q

In this histological H&E stained section which part of Hyaline cartilage is eosinophilic

A

perichondrium

44
Q

Which layer contains the chondrogenic cells that produce chondroblasts

A

perichondrium

45
Q

These cells are synthesizing and secreting extracellular matrix and allowing for the growth of the cartilage through appositional growth

A

chondroblasts

46
Q

what pushes newly divided Hyaline cartilage further apart from the isogenous groups

A

secretion of ECM

47
Q

Why is hyaline cartilage matrix is basophilic

A

GAGs

48
Q

This matrix has just been recently secreted and is richer in GAGs and poor in collagen

A

territorial matrix

49
Q

In this matrix, collagen is more abundant

A

interterritorial matrix

50
Q

Which type of matrix is more basophilic?

A

territorial matrix

51
Q

Why is the territorial matrix more basophilic

A

high concentration of GAGs

52
Q

Indicates that the chondrocytes recently underwent mitosis

A

isogenous group

53
Q

Which organelles indicate that the cells are actively engaged in the production of the extracellular matrix leading to the cartilage’s interstitial growth

A

Golgi & RER

54
Q

What types of fibers are in Elastic cartilage

A

Type II collage & elastic

55
Q

What type of properties do Elastic fibers give elastic cartilage

A

pliability and resilience

56
Q

can be found composing the auricle (pinna) of the ear, a portion of the auditory canal, the auditory (pharyngotympanic) tube, and the epiglottis

A

Elastic cartilage

57
Q

is a perichondrium associated with elastic cartilage

A

Yes

58
Q

In histological section, the extensive elastic fibers are visible as a dense network of

A

branching and anastomosing fibers

59
Q

What type of stain has to be used for elastic cartilage

A

Special stain

60
Q

elastic cartilage has a higher ratio of __________ than hyaline cartilage

A

chondrocytes to matrix

61
Q

elastic cartilage has fewer cells per ______ than hyaline cartilage

A

isogenous group

62
Q

you can see the large white or unilocular adipose cells in the elastic cartilage of what?

A

epiglottis

63
Q

What replaces elastic cartilage in the epiglottis as people age

A

Adipose

64
Q

What cartilage has less proteoglycans than other cartilages

A

Fibrocartilage

65
Q

What types of fibers are in fibrocartilage

A

type I and II collagen

66
Q

Found in intervertebral discs, pubic symphysis, major tendon-bone anchorages

A

Fibrocartilage

67
Q

Does fibrocartilage have a perichondrium

A

No

68
Q

fibrocartilage is found in areas of the body that undergo

A

pulling forces and compression

69
Q

contains chondrocytes arranged in long rows, separated by course type I collagen fiber

A

fibrocartilage

70
Q

fibrocartilage has fewer ________ than hyaline or elastic cartilage

A

chondrocytes

71
Q

chondrocytes aligned along collagen bundles either singularly or in isogenous groups in what type of cartilage

A

fibrocartilage

72
Q

Often fibrocartilage is seen next to

A

dense connective tissue

73
Q

the fibrocartilage matrix is more acidophilic than the other cartilage types because of

A

Type I collagen

74
Q

The type one collagen is laid down along. . .

A

stress lines

75
Q

of the three different types of cartilage what defines the characteristics of each tissue

A

ECM composition

76
Q

Which type of cartilage is considered to be an intermediate between hyaline cartilage and dense connective tissue?

A

Fibrocartilage

77
Q

Can withstand both compression and shearing forces

A

Fibrocartilage