Cartilage Bone Development Flashcards
What is the structural function of cartilage and matrix
Keeps us upright
What 3 types of cartilage are there , give examples
Hyaline - articular joints,ribs,trachea
Fibro - ligaments
Elastic - ear, larynx
What is the main component of hyaline cartilage like ribs and articular joints
Hyaluronic acid
In between bones like tibia and femur in knee is cartilage, what cells are there
Chondrocytes spaced far apart
Bone develops from cartilage. What is cartilage
A precursor
What would happens in articular joints if no cartilage ecm
Joint movement would be painful or they would lock eg in arthritis
Which 2 components are major in cartilage ecm
Collagen type II
Aggrecan
Which syndrome is caused by lack of collagen which causes hyper extensive joints
Ehlers danlos syndrome eg col1a1 mutation
What allows hydration of ecm and why important
Sulphated aggrecan attracts na charges and causes osmosis into the ecm
Allows withstand of compression
Produces swelling pressure (turgor)
Which type of organelles are chondrocytes rich of and why
Rer and Golgi
Production of aggrecan and col II
What 3 types of chondrocytes are there and why
A vascular (withstand hypoxia)
Alymphatic (no lymphs in ecm)
Aneuronal (no neurones)
Which stem cells produce chondrocytes to produce cartilage
Mesenchymal sc
What other cells do msc make
Bone, adipose cells, muscle cells ,
What does msc express which turns on chondrocytes pathway
Sox 9 (hmg box dna binding tf)
What does sox9 turn on
Col2a for collagen 2 production and pathway for chondrocytes