Cardiovascular Disease (Exam 1) Flashcards
Cardiovascular disease definition
atheroscleortic process characterized by a thickening in the intimal layer of the blood vessel wall caused by a local build up of lipids
CVC contributers (8)
- Heredity (genes)
- Smoking
- HTN
- Diabetes
- High cholesterol
- Age
- Endothelial injury
- Areas of sheers stress
Fatty streaks
asymptomatic; begin at birth
“foam cells”; build on each other and balloon out
plaque
elevated lump that thickens& decreases lumen
Can progress to occlude artery
Myocardial Ischemia (MI)
Lack of blood flow to the cells (lack of oxygen)
causes pain in heart muscle due to lack of oxygen to myocardium
Angina pectoris definition
episodic pain/crushing sensation in the chest caused by reversible MI
reversible by decreasing demand
Contributers to Angina Pectoris (4)
- Obstruction
- Increased metabolic demands that the heart can’t keep up with
- low blood hemoglobin (dec. ability to deliver oxygen)
- Pulmonary disease
Why are women at an increased risk to die from angina pectoris
they have atypical symptoms that are either ignored or misdiagnosed.
Stable Angina definition
chronic exertional angina
occurs when flow reserve of 1+ coronary arteries is limited; manifests during increased demand/physiological stress
Stable angina TX
rest 5-10 minutes
Nitroglycerine (vasodialator)
RF management
Unstable (pre infarction) angina definition
life threatening
Similar to MI, but artery is not completely occluded (80-90%)
Unstable (pre infarction) angina S&Sx
- crescendo angina
- angina w/ minimal exertion/@ rest
- angina after recent MI
Unstable angina is a called pre infarction angina because..
usually progresses to MI; life threatening if untreated
Unstable angina RX
pharmological/surgical intervention
collaterals
new vessels created by the body to go around the blockage
Prinzmetal/Variant Angina
caused by artery spasm
body becomes abnormally over reactive to vasoconstricting agents; s&sx occurs @ rest and early morning
Prinzmetal/variant angina contributers
- smoking
2. cocaine