Cardiovascular Flashcards
Isolated Systolic HTN
Elevated systolic with normal diastolic. Good predictor of CV events in the elderly. Vascular compromise.
Stage 1 HTN range
140-159 OR 90-99 mm Hg
HTN treatment goals for DM, kidney disease, and increased risk for stroke.
130/80 mm Hg
Lab tests for hypertension
urinalysis, blood glucose, hematocrit and lipid panel, serum potassium, creatinine, and calcium
Risk factors for cardiovascular disease
Hypertension • Obesity (body mass index >30 kg/m2) • Dyslipidemia • Diabetes mellitus • Cigarette smoking • Physical inactivity • Microalbuminuria, estimated glomerular filtration rate 55 for men, >65 for women) • Family history of premature CVD
Identifiable causes of HTN
Sleep apnea • Drug induced/related • Chronic kidney disease • Primary aldosteronism • Renovascular disease • Cushing’s syndrome or steroid therapy • Pheochromocytoma • Coarctation of aorta • Thyroid/parathyroid disease
Stage 1 Hypertension - treatment without compelling indications
Thiazide-type diuretics for most. May consider ACEI, ARB, BB, CCB, or combination
Stage 2 Hypertension - treatment without compelling indications
2-drug combination for most (usually thiazidetype diuretic and ACEI, or ARB, or BB, or CCB).
Compelling indication - Heart failure
THIAZ, BB, ACEI, ARB, ALDO ANT
Compelling indication - Post myocardial infarction
BB, ACEI, ALDO ANT
Compelling indication - High CVD risk
THIAZ, BB, ACEI, CCB
Compelling indication - Diabetes
THIAZ, BB, ACEI, ARB, CCB
Compelling indication - Chronic kidney disease
ACEI, ARB
Compelling indication - Recurrent stroke prevention
THIAZ, ACEI
Lifestyle modification for HTN
Components of lifestyle modifications include weight reduction, DASH eating plan, dietary sodium reduction, aerobic physical activity, and moderation of alcohol consumption.
Weight reduction drop in SBP
5-20
DASH diet drop in SBP
8-14
Sodium reduction drop in SBP
2-8
Exercise drop in SBP
4-9
Alcohol consumption limits (<2 drinks per day) drop in SBP
2-4
thiazide diuretics
suffix “ide” first line unless compelling indication not to use.
ACE inhibitor
suffix “pril” Use in high renin states and DM
ARB
suffix “sartan” Use in high renin states, DM, alternative to an ACE
Beta blockers
suffix “lol” Not for use in uncomplicated HTN but a god add on medication
Calcium channel blockers
suffix “dipine” Use for isolated systolic HTN
How long do you trial lifestyle modifications
3 months
Common side effect of HCTZ
erectile dysfunction
What medication should not be used with a calcium channel blocker?
HCTZ - no synergism
What medication should not be used in pregnancy?
ACE/ARB
General population - total cholesterol goal
<200
General population - LDL goal
<130
General population - HDL goal
40-60
General population/DM -triglycerides
< 150
DM patients - total cholesterol goal
no recommendation
DM patients - LDL goal
<100
DM patients - HDL goal
> 40 males, >females
Medication with the best effect on LDL
statins, slight decrease with niacin
Medication with the best effect on total cholesterol
statins, slight decrease with niacin
Medication with the best effect on HDL
niacin, slight increase with statins and tricor
Medication with the best effect on triglycerides
fibrates, omega 3s, slight decrease with statins and niacin
Clinical signs and symptoms of heart failure
tachypenea, crackles, tackycardia, possibly HTN, S3 and S4, peripheral edema possible
What medication should you never use with heart failure?
calcium channel blockers
stenotic valves
do not OPEN properly
regurgitant valves
do not CLOSE properly
Associated findings aortic stenosis
angina, syncope, HF
Aortic stenosis complications (ASC)
A - angina
S - syncope
C - congestive heart failure
Aortic regurgitation - assoc findings
angina, HF, dizziness, chest pain
mitral stenosis - assoc findings
dyspnea, afib
mitral regurgitation - assoc findings
SOB, fatigue, HF
mitral regurgitation - etiology
congenital conditions, rheumatic heart disease, acute endocarditis, MVP, calcufied annulus
mitral regurgitation - physical exam
PMI displaced laterally and is diffuse, murmur is holosystolic and apical, transmission to the axilla and sternum, usually grade II or more
mitral valve prolapse
most common in adults, common click, can have palpitations and chest pain
most common murmur in adults
mitral valve prolapse
What class of drugs is verapamil?
Calcium channel blocker