Cardiology Flashcards
Screening for end organ damage in hypertension?
Urine dip/urine ACR and U&Es
ECG, CXR and Echo
Fundoscopy to look for hypertensive retinopathy -» CT head if papilloedema
What indications of secondary HTN should you look for on examination?
Hands: Radio-radial and radio-femoral delay (co-arctation)
Recheck BP manually and confirm on ambulatory monitoring.
Face: Acromegalic face, Cushingoid facies
Abdo: PKD or renal bruit in renal artery stenosis
What are the causes of hypertension? (4 subtypes)
Vast majority have primary hypertension.
Renal- ADPKD, renovascular disease
Endocrine- Primary hyperaldosteronism (Conn’s), Cushings, Acromegaly or Phaechromocytoma
Cardio- Aortic co-arctation
Pre-eclampsia in pregnancy
How would you exclude secondary causes of hypertension?
Renin angiotensin ratio (ensure off drugs that affect result I.e beta blockers, ACEi and CCB)- for hyperhyperaldosteronism
Plasma and/or urine metanephrines in phaechromocytoma.
MRA in renal artery stenosis.
IGF1 and OGTT/MRI head in Acromegaly.
Overnight dexamethasone suppression test in Cushings.
When should you treat stage 1 HTN?
If evidence of end organ damage, history of IHD, diabetes, CKD or Qrisk >20%
When should you arrange admission for hypertension
Severe hypertension and grade 3 or 4 retinopathy (or new end organ damage)
Suspected secondary hypertension
Give the HTN management guidelines.
> 55 or afrocarribean= CCB
<55 = ACEi
Then the other or thiazide- like diuretics
All 3
Add Spiro if K <4.5 or beta blocker or alpha blocker if K >4.5
When would you consider intravenous antihypertensives with invasive BP monitoring?
Encephalopathy/stroke/myocardial infarction/acute LVF secondary to malignant hypertension.
Causes of papilloedema?
Raised ICP- SOP, BIH, cavernous sinus thrombosis
Accelerated phase hypertenion
Secondary prevention drugs in IHD?
Beta blockers
Ticagrelor/Clopidogrel
ACEi
Statin
Acute management of ACS
Aspirin loading and Ticagrelor/Prasugrel (in STEMI)
Fondaparinux
In STEMI PPCI within 12 hours of sumptoms and within 120 minutes of when fibrinolysis could have been given.
In NSTEMI and unstable angina-> angiography +/- Stent
CABG
What are the latest guidelines on screening of malignancy in unprovoked DVT?
According to the latest NICE guidelines do not offer further investigations for cancer to people with unprovoked DVT or PE unless they have relevant clinical symptoms or sign.
Bloods tests and examination and full history as minimum.
When would you do thrombophilia testing in patients with unprovoked DVT?
Planned to stop anticoagulation and first degree relative with history of VTE
Can offer antiphospholipid in those who plan to stop anticoagulation but don’t have a FH.
When would you offer IVC filter?
In patients with VTE for which anticoagulation is contraindicated or the patient has had recurrence of VTE whilst on anticoagulation (only after confirming compliance, measuring appropriate levels and trialling on alternative anticoagulation).
What would you do In suspected DVT with positive d-dimer and negative USS scan?
Stop anticoagulation and reassess with USS in 6-8 days time.