Cardiology Flashcards
Common symptoms of stable CAD in elderly patients?
SOB, lightheadedness, fatigue (without CP) during exertion
Best next test for patients with suspected stable CAD?
Non-invasive stress testing … Pharmacologic or Exercise
2 options for pharmacologic stress testing for patients with suspected stable CAD?
Dobutamine ECHO, Adenosine myocardial perfusion
Initial evaluation of choice in patients with suspected stable CAD?
Non-invasive stress testing
DOC for patients with stable CAD (+) non-invasive stress testing?
ASA + statin + b blocker
What is considered a high-risk feature on stress-testing for patient with suspected stable CAD?
ST depression
In addition to medical treatment (ASA + statin + b blocker), what is an additional treatment for patients with (+) stress test and high-risk features?
Percutaneous coronary angiogram … to assess for stent placement + CABG
72 yo male presents with arrythmia and pulmonary symptoms – diagnosis?
MAT … Multifocal Atrial Tachycardia
Appearance of MAT on EKG?
Distinct P waves with different morphologies; Irregular rhythm (variable PR and RR segments); Tachycardia
Best treatment for MAT?
Treat underlying pulmonary disease
Patient with MAT does not show improvement of arrhythmia on EKG after treatment of underlying pulmonary disease – what is next step in treatment?
Check for electrolyte disturbances .. then correct electrolyte disturbances
Patient with MAT does not show improvement of arrhythmia on EKG after treatment of underlying pulmonary disease and electrocyte disturbances – what is next step in treatment?
b blockers, CCBs
2 DOC for patients with A-Fib with RVR?
b blockers, Non-DHP CCBs
2 examples of Non-DHP CCBs?
Diltiazem, Verapamil
Best management of hypertrophic cardiomyopathy (HCM)?
Implantable cardioverter-defibrillator (ICD)
Optimal medical therapy for patient with systolic CHF with severe LV dysfunction?
b blocker, ACEI, Aldosterone antagonist, Diuretics
Next step of management for patient with systolic CHF + severe LV dysfunction who is unresponsive to b blocker, ACEI, Aldosterone antagonist, Diuretics?
Add isosorbide dinitrate + hydralazine
Best pharmacologic management for patients with suspected Acute Coronary Syndrome (ACS)?
ASA 325mg + NTG (if experiencing active CP)
Best workup for patients with suspected Acute Coronary Syndrome (ACS)?
Troponin I levels … 3 hours apart
Clinical presentation of acute mitral valve prolapse, due to mitral chordae tendinae rupture?
Sudden-onset hypotension, pulmonary edema
Cardiac PE finding in setting of acute mitral valve prolapse, due to mitral chordae tendinae rupture?
Hyperdynamic precordium
Auscultation PE finding in setting of acute mitral valve prolapse, due to mitral chordae tendinae rupture?
Decrescendo holosystolic murmur at cardiac apex
Diagnosis of acute mitral valve prolapse, due to mitral chordae tendinae rupture is confirmed via …
Bedside ECHO
Which patients are at increased risk of acute mitral valve prolapse, due to mitral chordae tendinae rupture?
Connective tissue disease
ECHO findings for patients with acute mitral valve prolapse, due to mitral chordae tendinae rupture?
Rapid equalization of LA and LV pressures
What clinical feature can be used to distinguish Ehlers-Danlos from Marfans?
EDS is much more likely to present with skin findings (unhealed scars)
There is a bidirectional link between depression and ___ … Depression is an independent risk factor for increased morbidity/mortality in ___
CAD
Best management of patient with Acute Coronary Syndrome (unstable angina, or NSTEMI)?
Dual antiplatelet therapy (ASA + clopidogrel), b blockers, NTG, Statin, Heparin
Best management of patient with STEMI?
Cardiac catheterization + revascularization within 90 minutes of presentation
Highly specific finding of cardiac tamponade, requiring immediate intervention?
Early diastolic collapse of RA/RV on ECHO
Additional specific finding of cardiac tamponade, requiring immediate intervention?
JVD plethora, with lack of inspiratory collapse
Best intervention for acute cardiac tamponade?
Catheter pericardiocentesis
Consequence of acute cardiac tamponade?
Impaired diastolic filling of R heart
Definition of elevated BP?
Systolic 120-129
Best management of elevated BP?
Lifestyle changes
Definition of Stage 1 HTN?
Systolic 130-139, Diastolic 80-89
Best management of Stage 1 HTN?
Lifestyle changes + 1 antihypertensive drug
Definition of Stage 2 HTN?
Systolic > 140, Diastolic > 90
Best management of Stage 2 HTN?
Lifestyle changes + 2 antihypertensive drugs
4 options for monotherapy in Stage 1 HTN?
ACEIs, ARBS, CCBs, Thiazide diuretics
Best combination therapy of 2 antihypertensive drugs in management of Stage 2 HTN?
ACEI + CCB
Which drug is NOT recommended in initial management of HTN?
B blockers
2 conditions in which B blockers would be indicated for initial management of HTN?
CAD, CHF
6 additional studies that should be ordered in patient with newly-diagnosed HTN?
Fasting lipid profile, BG, UA, serum electrolytes, creatinine, EKG
Best treatment for STEMI?
Percutaneous coronary intervention (PCI) within 90 minutes of first medical contact
Alternative best therapy for STEMI in patients who require transfer to PCI facility?
PCI within 120 minutes for patients
Best therapy for STEMI in rural setting where PCI is not possible?
Fibrolytic therapy
3 EKG findings that are diagnostic for STEMI?
New left BBB; > 1 mm ST elevation in all leads except V2 and V3; > 1.5 mm (in women) and > 2 mm (in men) ST elevations and leads V2 and V3
Hallmark of 2nd degree AV block type 2?
Intermittent non-conducted P waves
Best treatment of 2nd degree AV block type 2?
Pacemaker placement
How long should DVTs due to underlying surgery, pregnancy, trauma, OCP use be treated with anticoagulation therapy?
3-6 months
How long should idiopathic DVTs be treated with anticoagulation therapy?
> 6 months
Name the murmur … mid-systolic murmur at L upper sternal border; ECHO shows RA and RV dilation?
ASD
Additional heart sound heard in setting of ASD?
Wide and fixed splitting of S2
ASD is a type of ___ shunt
L-to-R
Most common congenital heart defect in adults?
Bicuspid aortic valve
2nd most common congenital heart defect in adults?
ASD
Clinical presentation of papulopustular rosacea?
Erythema in central face, flushing, telangiectasia, pustules
Best management for patients with papulopustular rosacea?
Topical metronidazole
Patients with rosacea also experience ___ symptoms
Ocular
3 ocular manifestations of rosacea?
Foreign body sensation, recurrent chalazion, conjunctivitis
Etiology of chalazion?
Inflammation of meibomian gland
Clinical presentation of chalazion?
Painless pea-sized nodule within eyelid
What accounts for cocaine-related chest pain?
Overstimulation of b1 and alpha1 receptors
MOA of cocaine?
Inhibition of presynaptic reuptake of norepinephrine
Initial DOC for management of cocaine-related chest pain?
Benzodiazepine
Role of Benzodiazepine in treatment of cocaine-related chest pain?
Reduce sympathetic outflow
Medication that is contraindicated in treatment of cocaine-related chest pain?
b blockers
Why are b blockers contraindicated in treatment of cocaine-related chest pain?
Can lead to excessive alpha-1 receptor vasoconstriction
35 yo female presents with cocaine-related chest pain; 2 hours after presentation, she reports persistent CP with new-onset R-sided weakness – diagnosis?
Aortic dissection
What accounts for Aortic dissection in setting of cocaine use?
Severe HTN after cocaine ingestion
Diagnostic test for Aortic dissection?
CT angiography, MRI, Transesophageal ECHO
Amiodarone is a CYP450 ___
Inhibitor … (SICKFACES.COM when I Am drinking GFJ)
How should a patient’s dose of warfarin be altered when Amiodarone is added to their drug regimen?
Amiodarone = CYP450 inhibitor … Slows metabolism of warfarin … Reduce warfarin dose by 25-50%
Best strategy for discontinuing amlodipine in a patient with well-controlled HTN, who has recently lost a healthy amount of weight?
Amlodipine is a long-acting medication … discontinuation can be achieved by taking the medication every-other-day … OR in lower lose tablets
Best strategy for discontinuing lisinopril in a patient with well-controlled HTN?
Lisinopril is a short-acting medication … discontinuation can ONLY be achieved by taking the medication every day in a smaller dose
How can you calculate a CHADS2-VASC score for a patient with newly-diagnosed A-Fib?
CHF, HTN, Age > 75 (2 points), DM, Stroke (2 points), Vascular disease, Age 65-74, Sex (female)
What is the role of CHADS2-VASC score in newly-diagnosed A-Fib?
Estimate thromboembolic risk
Best treatment for A-Fib patients who are hemodynamically unstable?
Emergency cardioversion
Best treatment for A-Fib patients who are hemodynamically stable?
Medical therapy
2 DOC for A-Fib rate control?
Diltiazem, b blockers
Best additional management for patients with CHADS2-VASC score <2?
Periodic follow-up
Best additional management for patients with CHADS2-VASC score >2?
Anticoagulation
62 yo male presents with new-onset, RLE pain; Reports CABG performed 3 months ago; Presented to ED 2 nights ago for recurrent CP; Troponin = elevated, angiogram was (+) for coronary artery stenosis; Patient was treated with heparin, anti-platelet agents, b blocker, NTG; Stenting was performed; ECHO was (-); PE shows RLE that is cool to touch, diminished pulses; Labs show thrombocytopenia – diagnosis?
Type 2 HIT
3 hallmark clinical findings for Type 2 HIT?
Thrombocytopenia, Onset after Heparin administration, Thrombosis
Etiology of Type 2 HIT?
Auto-Ig directed against heparin-platelet factor 4 complexes
Difference between Type 1 HIT and Type 2 HIT?
Type 1 = non-immune mediated; Type 2 = immune mediated
Diagnostic test for Type 2 HIT?
HIT antibody testing
Best management of Type 2 HIT?
Discontinue all heparin-containing products; Begin non-heparin anticoagulants … Don’t wait for (+) HIT antibody testing to return
2 types of non-heparin anticoagulants that can be used in setting of Type 2 HIT?
Argatroban, Fondaparinux
Approach to future heparin use in a patient diagnosed with Type 2 HIT?
Avoid all forms of heparin for life
2 long-term treatment options for patients with A-Fib?
Rate control + Anticoagulation; Rhythm control
2 clinical settings in which Rhythm control is the preferred treatment for patients with A-Fib?
Inability to maintain HR control with rate-control agents; Persistence of symptomatic CHF episodes while on rate-control agents
2 anti-arrhythmic agents used in treatment of A-Fib for patients with no CAD or structural heart disease?
Flecainide, Propafenone
1 anti-arrhythmic agent used in treatment of A-Fib for patients with LV hypertrophy?
Amiodarone
1 anti-arrhythmic agent used in treatment of A-Fib for patients with CAD?
Sotolol
2 anti-arrhythmic agents used in treatment of A-Fib for patients with CHF?
Amiodarone, Dofetilide
3 classes of anti-HTN drugs that affect lithium levels?
Thiazide diuretics, ACEIs/ARBs, Spironolactone
1 additional drug that affects lithium levels?
NSAIDs
2 classes of anti-HTN drugs that affect do NOT lithium levels?
CCBs, Loop diuretics
Lithium is metabolized by which organ?
Kidney
In a patient with existing AAA, control of which risk factor is most important for decreasing likelihood of AAA expansion/rupture?
Smoking cessation … (not HTN control)
Etiology of early post-MI acute pericarditis?
Peri-infarction pericarditis
Typical time-frame of post-MI acute pericarditis?
Within 4 days of MI
Etiology of late post-MI acute pericarditis?
Dressler Syndrome
EKG findings associated with post-MI acute pericarditis?
Diffuse ST segment elevations, PR depression
Cardiac auscultation results for post-MI acute pericarditis?
Friction rub
Best treatment for post-MI acute pericarditis?
High-dose ASA
Best treatment for acute pericarditis … viral OR idiopathic etiology?
NSAIDs + colchicine
Why are NSAIDs + colchicine + corticosteroids NOT recommended as treatment for post-MI acute pericarditis?
NSAIDs ma impair cardiac healing, increase risk of septal/free wall rupture
Best test for initial diagnostic evaluation of stable CAD?
Exercise EKG … (stress test)
What might account for a holosystolic heart murmur heart in patient with acute decompensated heart failure?
Holosystolic murmur = dilated cardiomyopathy causing MR
3 initial tests that should be ordered for patient with acute decompensated heart failure?
Pulse Ox, CXR, ECG
Most important initial step in treatment of acute decompensated heart failure?
Decrease preload … diuretics (furosemide)
Alternative medication used to decreased preload in patients with acute decompensated heart failure (not furosemide)?
Vasodilators (nitroprusside, NTG)
3 characteristic heart sounds heard in aortic stenosis?
Single A2, Delayed carotid pulse, Crescendo-Decrescendo systolic murmur
___ refers to Delayed carotid pulse seen in aortic stenosis?
Parvus et tardus
What accounts for Single A2 heard in aortic stenosis?
Delayed closure of aortic valve
If a patient is preparing to undergo cardiac catheterization, which home medication should be discontinued?
Metformin
Why should Metformin be discontinued prior to cardiac catheterization?
Increased risk of lactic acidosis … huge amount of iodine contrast exposure
Creatinine level that contraindicates use of metformin?
Creatinine > 1.5
Change to RA pressure in setting of hypovolemic shock?
Decreased
Change to PCWP in setting of hypovolemic shock?
Decreased