Cardio Flashcards
Interchangeable terms with CAD
Atherosclerotic heart disease
Ischemic heart disease
MCC of CP when source is clearly not cardiac
GI
Best initial test for CP
EKG (regardless of cause)
Why are men more at risk for MI under 50
Protective effect of Estrogen
This wears off at menopause and the risk becomes equal to males
Useful Hx in Ischemia
Duration Quality Location Radiation Frequency Alleviating Precipitating
Worst RF for CAD
DM
MC RF for CAD
HTN
Unmodifiable RFs for CAD
Age
Sex
Heredity
Clear RFs for CAD
DM Smoking - Risk x2 HTN - goal 140/90, 130/80 in DM Hyperlipidemia FHx of premature CAD Age > 45 men, 55 women
What is premature CAD
Males less than 55
Females less than 65
When is FHx of CAD relevant
First degree relative
Premature in family
Goal for LDL to prevent CAD
Less than 100
Less than 70 in DM
MCC of death in DM
Cardiovascular
Weight loss effect on BP
1 Kg decreased = 1 mmHg decreased
Best way to decrease BP
Weight loss
Best way to increase HDL
Exercise
Etiology of Takatsubo cardiomyopathy
Massive catecholamine discharge from emotional stress
These are NOT RFs for CAD
Chlamydia
Elevated CRP
Elevated homocysteine
Greatest improvement in risk for CAD
Stop smoking
Features of non-ischemic CP
Pleuritic Positional Tender Knife-like Lasts a few seconds
Why are men more at risk for MI under 50
Protective effect of Estrogen
This wears off at menopause and the risk becomes equal to males
Useful Hx in Ischemia
Duration Quality Location Radiation Frequency Alleviating Precipitating
When is FHx of CAD relevant
First degree relative
Premature
MCC of death in DM
Cardiovascular
Weight loss effect on BP
1 Kg decreased = 1 mmHg decreased
Best initial test for all forms of CP
EKG
Presentation of ischemic pain
Dull/sore
Squeezing
Features of inferior wall ischemia
Brady
Hypotension
+/- Dizziness
Nitrate effect on CP
↑ in GERD
↓ in Angina
Auscultation findings in MI
Wide split S2 LBBB New S4 S3 New AR - Aortic dissection New MR - Papillary muscle dysfunction
What causes wide split S2
RBBB
Pulm HTN
Pulmonic stenosis
RVH
What causes paradoxic S2
LBBB
HTN
AS
LVH
What causes fixed split S2
ASD
What causes S4 gallop
LVH (atrial systole)
Long standing HTN
What causes S3 gallop
Underlying CHF
Causes of pleuritic CP
PN PE Pericarditis - PR depression PTX Pleuritis
CP w/ chest wall tenderness:
Most accurate test:
Costochondritis
Physical exam
CP w/ radiation to back, unequal BP b/w arms:
Most accurate test:
Aortic dissection
CXR w/ widened mediastinum
CT, MRI or TEE confirms
CP w/ pain worse lying flat, age
Pericarditis
EKG w/ ST elevation everywhere, PR depression
CP w/ epigastric discomfort, pain better w/ eating:
Most accurate test:
Duodenal ulcer
Endoscopy
CP w/ bad taste, cough, hoarseness:
Most accurate test:
GERD
Resonse to PPIs, AlOH, Mg(OH)2, viscous lidocaine
CP w/ cough, sputum, hemoptysis:
Most accurate test:
PN
CXR
CP w/ sudden onset SOB, tachy, hypoxia:
Most accurate test:
PE
Spiral CT, V/Q in pregnancy
CP w/ sharp pleuritic pain, tracheal deviation:
Most accurate test:
PTX
CXR
Worst prognostic combination with CP
SOB
Best initial test for all forms of CP
EKG
When do CKMB and Troponins begin to rise
4hrs
When do CKMB and Troponins peak
12-24hrs
How long before CKMB resolves
3-4 days - Makes it good to test for re-infarction
When to do exercise stress test in setting of CP
Etiology not clear
EKG not diastolic
When to use Prasugrel in ischemic heart disease
Pts undergoing angioplasty and stenting
NOT in >75 due to risk of hemorrhage and stroke
Calculate a pts max HR
220-Age
What indicates ischemia on EKG
ST depression
What can cause baseline EKG abnormalities
LBBB
LVH
Digoxin - Downsloping ST
Pacer
2 ways of evaluating ischemia w/o EKG
Thallium uptake
Echo - wall motion abnormalities
Contraindications to ETT
Cardiac instability - Current CP
Pt can’t exercise
MCC ischemic heart disease
Atherosclerosis
Calculate O2 delivery
CO x Hb/HCT x O2 sat
Why does normal myocardium pick up thallium
Looks like K
Differentiate infarct and ischemia on thallium uptake
Ischemia uptake returns to normal at rest
Increase myocardium O2 consumption w/o exercise
Dipyridamole or adenosine with Thallium
Dobutamine with ECHO
When to avoid dipyridamole
Asthmatics - Can cause bronchospasm
The lower the pretest likelihood of disease
The higher the rate of false positives
Why do we do angiography in ischemic heart disease
Determine bypass surgery vs angioplasty
Most accurate method of detecting CAD
Angiography
When does CABG decrease mortality
3 vessel disease or Left main
2 vessel disease in DM
2-3 vessel with Low EF
LV dysfunction
What lowers mortality in CAD
Aspirin BBs tPA Angioplasty Clopidogrel ACEIs if ↓ EF Statins if LDL > 100
What is the purpose of Holter
Rhythm monitoring (A-fib , flutter, premature beats, V-tach)
What lowers mortality in ischemic heart disease
Aspirin
BBs
Statins if LDL > 100
Best mortality benefit in chronic angina
Aspirin
BBs
When to use clopidogrel in ischemic heart disease
Aspirin intolerance
Recent angioplasty w/ stenting
AE Ticlopidine
Neutropenia
TTP
What do ACEIs/ARBs do in CAD
Decrease EF
When to give ACEIs/ARBs in CAD
Regurgitant valvular disease (Decreased LVEF)
What to do in hyperkalemia with ACEIs/ARBs
Switch to hydralazine and nitrates
What are CAD equivalents (LDL goal
PAD
Carotid disease
Aortic disease
DM
MC AE statins
Liver dysfunction (elevated transaminases)
Which lipid lowering drugs lower mortality the most in CAD
Statins
AE statins
Elevated transaminases
Myositis
AE niacin
Elevated glucose and uric acid
Pruritis
AE fibrate derivatives
Increase risk of myositis when combined w/ statins
AE Cholestyramine
Flatus, ABD cramping
AE ezetimibe
Nearly useless but well tolerated
Effect of CCBs on CAD
May increase mortality
ONLY time to use CCBs in CAD
Severe asthma
Prinzmetal
Cocain-induced CP
Max meds don’t control pain
AE CCBs
Edema
Constipation (verapamil)
Heart block
What lowers mortality in CAD
Aspirin BBs tPA Angioplasty Clopidogrel ACEIs if ↓ EF Statins if LDL > 100
Best therapy in acute coronary syndrome
PCI esp w/ ST elevation
MCC death in USA
Acute coronary syndrome
Only way to determine etiology in acute coronary syndromes
EKG and Enzymes
Features of unstable angina
New pain
Worse pain
Rest pain
What is the sequelae of unstable angina
NSTEMI
Risk factors for unstable angina to progress to NSTEMI
Repetitive/Prolongued Pain Persistent EKG changes Hypotension Elevated cardiac markers Sustained V-tach Syncope EF
Heart sound in ACS
S4
What is associated with constrictive pericarditis
Kussmaul sign
Increased JVP on inhalation
Rx Dressler
NSAIDS and Aspirin +/- steroids
Displaced PMI is characteristic of
LVH
Dilated cardiomyopathy
Leads affected in Anterior wall
V2-4
Leads affected in Inferior wall
II, III, aVF
PR > 200ms associated with
1st degree AV block
Leads affected in posterior wall
ST depression in V1-2
Most important next step in ACS
Aspirin then Angioplasty then ICU
Greatest mortality benefit in ACS
Angioplasty
MCC death first several days after MI
Ventricular arrhythmia
How is PCI superior to thrombolytics
Survival and Mortality benefit
Fewer hemorrhage complications
Less MI complications
When to DEFINITELY do PCI (ie. thrombolytics are contraindicated)
Recent surgery Melena BP > 180/110 Aortic dissection Stroke
When does PCI need to be performed
Within 90min of pt arrival
PCI complications
Rupture
Restenosis
Hematoma
Most important method of preventing restenosis after PCI
Drug-eluting stent (paclitaxel, sirolimus)
When can thrombolytics be administered
Within 12hrs
Door to needle time
30min
When to do CABG in late presentation MI (>12hrs)
Good anatomy
Cardiogenic shock
Mechanical repair
When to do emergency CABG
Failed PCI
Persistent/Recurrent ischemia refractory to meds
ACS, who gets Aspirin
Everyone
BIT
ACS, who gets clopidogrel
Aspirin not tolerated
Pt undergoing angioplasty and stenting
ACS, who gets BBs
Everyone
ACS, who gets ACEi/ARBs
Everyone
Best for EF
ACS, who gets statins
Everyone
Best for LDL>100
ACS, who gets O2, nitrates
Everyone
No mortality benefit
ACS, who gets Heparin
After thrombolytics/PCI to prevent restenosis
Initial therapy w/ ST depression and other NSTE events
ACS, who gets CCBs
Can’t use BBs
Cocaine
Prinzmetal or vasospastic variant
When can you give glycoprotein IIb/IIIa inhibitors
ACS w/ angioplasty and stenting
ST depression
NSTEMI
Best for NSTEMI
Heparin
Glycoprotein IIb/IIIa inhibitors
What does “not better” mean in STE ACS
Persistent pain
S3 gallop or CHF
Worse EKG changes or SVT
Rising troponins