Cardio Flashcards
Interchangeable terms with CAD
Atherosclerotic heart disease
Ischemic heart disease
MCC of CP when source is clearly not cardiac
GI
Best initial test for CP
EKG (regardless of cause)
Why are men more at risk for MI under 50
Protective effect of Estrogen
This wears off at menopause and the risk becomes equal to males
Useful Hx in Ischemia
Duration Quality Location Radiation Frequency Alleviating Precipitating
Worst RF for CAD
DM
MC RF for CAD
HTN
Unmodifiable RFs for CAD
Age
Sex
Heredity
Clear RFs for CAD
DM Smoking - Risk x2 HTN - goal 140/90, 130/80 in DM Hyperlipidemia FHx of premature CAD Age > 45 men, 55 women
What is premature CAD
Males less than 55
Females less than 65
When is FHx of CAD relevant
First degree relative
Premature in family
Goal for LDL to prevent CAD
Less than 100
Less than 70 in DM
MCC of death in DM
Cardiovascular
Weight loss effect on BP
1 Kg decreased = 1 mmHg decreased
Best way to decrease BP
Weight loss
Best way to increase HDL
Exercise
Etiology of Takatsubo cardiomyopathy
Massive catecholamine discharge from emotional stress
These are NOT RFs for CAD
Chlamydia
Elevated CRP
Elevated homocysteine
Greatest improvement in risk for CAD
Stop smoking
Features of non-ischemic CP
Pleuritic Positional Tender Knife-like Lasts a few seconds
Why are men more at risk for MI under 50
Protective effect of Estrogen
This wears off at menopause and the risk becomes equal to males
Useful Hx in Ischemia
Duration Quality Location Radiation Frequency Alleviating Precipitating
When is FHx of CAD relevant
First degree relative
Premature
MCC of death in DM
Cardiovascular
Weight loss effect on BP
1 Kg decreased = 1 mmHg decreased
Best initial test for all forms of CP
EKG
Presentation of ischemic pain
Dull/sore
Squeezing
Features of inferior wall ischemia
Brady
Hypotension
+/- Dizziness
Nitrate effect on CP
↑ in GERD
↓ in Angina
Auscultation findings in MI
Wide split S2 LBBB New S4 S3 New AR - Aortic dissection New MR - Papillary muscle dysfunction
What causes wide split S2
RBBB
Pulm HTN
Pulmonic stenosis
RVH
What causes paradoxic S2
LBBB
HTN
AS
LVH
What causes fixed split S2
ASD
What causes S4 gallop
LVH (atrial systole)
Long standing HTN
What causes S3 gallop
Underlying CHF
Causes of pleuritic CP
PN PE Pericarditis - PR depression PTX Pleuritis
CP w/ chest wall tenderness:
Most accurate test:
Costochondritis
Physical exam
CP w/ radiation to back, unequal BP b/w arms:
Most accurate test:
Aortic dissection
CXR w/ widened mediastinum
CT, MRI or TEE confirms
CP w/ pain worse lying flat, age
Pericarditis
EKG w/ ST elevation everywhere, PR depression
CP w/ epigastric discomfort, pain better w/ eating:
Most accurate test:
Duodenal ulcer
Endoscopy
CP w/ bad taste, cough, hoarseness:
Most accurate test:
GERD
Resonse to PPIs, AlOH, Mg(OH)2, viscous lidocaine
CP w/ cough, sputum, hemoptysis:
Most accurate test:
PN
CXR
CP w/ sudden onset SOB, tachy, hypoxia:
Most accurate test:
PE
Spiral CT, V/Q in pregnancy
CP w/ sharp pleuritic pain, tracheal deviation:
Most accurate test:
PTX
CXR
Worst prognostic combination with CP
SOB
Best initial test for all forms of CP
EKG
When do CKMB and Troponins begin to rise
4hrs
When do CKMB and Troponins peak
12-24hrs
How long before CKMB resolves
3-4 days - Makes it good to test for re-infarction
When to do exercise stress test in setting of CP
Etiology not clear
EKG not diastolic
When to use Prasugrel in ischemic heart disease
Pts undergoing angioplasty and stenting
NOT in >75 due to risk of hemorrhage and stroke
Calculate a pts max HR
220-Age
What indicates ischemia on EKG
ST depression
What can cause baseline EKG abnormalities
LBBB
LVH
Digoxin - Downsloping ST
Pacer
2 ways of evaluating ischemia w/o EKG
Thallium uptake
Echo - wall motion abnormalities
Contraindications to ETT
Cardiac instability - Current CP
Pt can’t exercise
MCC ischemic heart disease
Atherosclerosis
Calculate O2 delivery
CO x Hb/HCT x O2 sat
Why does normal myocardium pick up thallium
Looks like K
Differentiate infarct and ischemia on thallium uptake
Ischemia uptake returns to normal at rest
Increase myocardium O2 consumption w/o exercise
Dipyridamole or adenosine with Thallium
Dobutamine with ECHO
When to avoid dipyridamole
Asthmatics - Can cause bronchospasm
The lower the pretest likelihood of disease
The higher the rate of false positives
Why do we do angiography in ischemic heart disease
Determine bypass surgery vs angioplasty
Most accurate method of detecting CAD
Angiography
When does CABG decrease mortality
3 vessel disease or Left main
2 vessel disease in DM
2-3 vessel with Low EF
LV dysfunction
What lowers mortality in CAD
Aspirin BBs tPA Angioplasty Clopidogrel ACEIs if ↓ EF Statins if LDL > 100
What is the purpose of Holter
Rhythm monitoring (A-fib , flutter, premature beats, V-tach)
What lowers mortality in ischemic heart disease
Aspirin
BBs
Statins if LDL > 100
Best mortality benefit in chronic angina
Aspirin
BBs
When to use clopidogrel in ischemic heart disease
Aspirin intolerance
Recent angioplasty w/ stenting
AE Ticlopidine
Neutropenia
TTP
What do ACEIs/ARBs do in CAD
Decrease EF
When to give ACEIs/ARBs in CAD
Regurgitant valvular disease (Decreased LVEF)
What to do in hyperkalemia with ACEIs/ARBs
Switch to hydralazine and nitrates
What are CAD equivalents (LDL goal
PAD
Carotid disease
Aortic disease
DM
MC AE statins
Liver dysfunction (elevated transaminases)
Which lipid lowering drugs lower mortality the most in CAD
Statins
AE statins
Elevated transaminases
Myositis
AE niacin
Elevated glucose and uric acid
Pruritis
AE fibrate derivatives
Increase risk of myositis when combined w/ statins
AE Cholestyramine
Flatus, ABD cramping
AE ezetimibe
Nearly useless but well tolerated
Effect of CCBs on CAD
May increase mortality
ONLY time to use CCBs in CAD
Severe asthma
Prinzmetal
Cocain-induced CP
Max meds don’t control pain
AE CCBs
Edema
Constipation (verapamil)
Heart block
What lowers mortality in CAD
Aspirin BBs tPA Angioplasty Clopidogrel ACEIs if ↓ EF Statins if LDL > 100
Best therapy in acute coronary syndrome
PCI esp w/ ST elevation
MCC death in USA
Acute coronary syndrome
Only way to determine etiology in acute coronary syndromes
EKG and Enzymes
Features of unstable angina
New pain
Worse pain
Rest pain
What is the sequelae of unstable angina
NSTEMI
Risk factors for unstable angina to progress to NSTEMI
Repetitive/Prolongued Pain Persistent EKG changes Hypotension Elevated cardiac markers Sustained V-tach Syncope EF
Heart sound in ACS
S4
What is associated with constrictive pericarditis
Kussmaul sign
Increased JVP on inhalation
Rx Dressler
NSAIDS and Aspirin +/- steroids
Displaced PMI is characteristic of
LVH
Dilated cardiomyopathy
Leads affected in Anterior wall
V2-4
Leads affected in Inferior wall
II, III, aVF
PR > 200ms associated with
1st degree AV block
Leads affected in posterior wall
ST depression in V1-2
Most important next step in ACS
Aspirin then Angioplasty then ICU
Greatest mortality benefit in ACS
Angioplasty
MCC death first several days after MI
Ventricular arrhythmia
How is PCI superior to thrombolytics
Survival and Mortality benefit
Fewer hemorrhage complications
Less MI complications
When to DEFINITELY do PCI (ie. thrombolytics are contraindicated)
Recent surgery Melena BP > 180/110 Aortic dissection Stroke
When does PCI need to be performed
Within 90min of pt arrival
PCI complications
Rupture
Restenosis
Hematoma
Most important method of preventing restenosis after PCI
Drug-eluting stent (paclitaxel, sirolimus)
When can thrombolytics be administered
Within 12hrs
Door to needle time
30min
When to do CABG in late presentation MI (>12hrs)
Good anatomy
Cardiogenic shock
Mechanical repair
When to do emergency CABG
Failed PCI
Persistent/Recurrent ischemia refractory to meds
ACS, who gets Aspirin
Everyone
BIT
ACS, who gets clopidogrel
Aspirin not tolerated
Pt undergoing angioplasty and stenting
ACS, who gets BBs
Everyone
ACS, who gets ACEi/ARBs
Everyone
Best for EF
ACS, who gets statins
Everyone
Best for LDL>100
ACS, who gets O2, nitrates
Everyone
No mortality benefit
ACS, who gets Heparin
After thrombolytics/PCI to prevent restenosis
Initial therapy w/ ST depression and other NSTE events
ACS, who gets CCBs
Can’t use BBs
Cocaine
Prinzmetal or vasospastic variant
When can you give glycoprotein IIb/IIIa inhibitors
ACS w/ angioplasty and stenting
ST depression
NSTEMI
Best for NSTEMI
Heparin
Glycoprotein IIb/IIIa inhibitors
What does “not better” mean in STE ACS
Persistent pain
S3 gallop or CHF
Worse EKG changes or SVT
Rising troponins
Next step for pts in STE ACS and are not getting better
Angiography and possible angioplasty
Where do you see cannon A waves
3rd degree AV block
Rx Symptomatic 3rd degree AV block
Atropine
Then Pacemaker
Most specific finding in Right ventricular infarction
STE in RV4
What does the right coronary supply
RV
AV node
Inferior wall
Rx RV infarctions
High volume fluid replacement
MC complications of MI
V-tach
V-fib
When to look for tamponade/free wall rupture after mI
Sudden loss of pulse
Rx v-tach/v-fib
Cardioversion/defibrillation
Then give BBs
Presentation of valve or septal rupture after MI
New onset murmur and pulm congestion
Most accurate test for valve or septal rupture
Echo
What to look for in septal rupture
Step-up in O2 sat from RA to RV
ie. sharp increase in O2 sat
Rx stable v-tach
Amiodarone
Procainamide
Lidocaine
When to use intraaortic balloon pump
Acute pump failure from anatomical problem fixed in OR
What to look for in reinfarction/infarction extension after MI
Recurrence of pain
New Rales
New bump in CKMB
Sudden onset pulm edema
Management of reinfarction/infarction extension after MI
EKG
Angioplasty
Aspirin, BBs, Nitrates, ACE, statins
Detection of aneurysms/mural thrombus post MI
Echo
Rx mural thrombus post MI
Heparin, then warfarin
Why do stress test before d/c after MI
Evaluate need for angiography (residual ischemia)
Only if patient is asymptomatic
Done at 5-7 days
Postinfarction meds
Aspirin
BBs
Statins
ACEIs (stop at 6wks if EF is NL)
Alternate drugs in postinfarction
Clopidogrel - Aspirin intolerance
ARBs - Cough w/ ACEI
Ticlopidine - Aspirin and Clopidogrel intolerance
MCC erectile dysfunction post-MI
Anxiety
Essential feature of CHF
Dyspnea
Difference between systolic and diastolic dysfunction
EF preserved in diastolic dysfunction
Can really only tell with Echo
MCC CHF
HTN causing cardiomyopathy
Myocardial muscle abnormality
Other causes of CHF
Valvular heart disease
MI
Rare causes of CHF
Alcohol Postviral Radiation Adriamycin Chagas Hemochromatosis Thyroid disease Peripartum Thiamine def
How to Dx CHF
Clinical Dx Dyspnea Orthopnea Rales JVD PND S3
Sudden onset dyspnea w/ clear lungs
PE
Sudden onset dyspnea w/ wheezing, increased expiratory phase
Asthma
Slow dyspnea w/ fever, sputum, unilateral rales/rhonchi
PN
Dyspnea w/ decreased breath sounds unilaterally, tracheal deviation
PTX
Dyspnea w/ circumoral numbness, caffein use, hx anxiety
Panic attack
Dyspnea w/ pallor gradual over days to weeks
Anemia
Dyspnea w/ pulsus paradoxus, decreased heart sounds, JVD
Tamponade
Dyspnea w/ palpitations, syncope
Arrhythmia (any)
Dyspnea w/ dullness to percussion at bases
Pleural effusion
Dyspnea w/ long smoking hx, barrel chest
COPD
Dyspnea w/ recent anesthetic use, brown blood not improved w/ O2, clear lungs, cyanosis
Methemoglobinemia
Dyspnea w/ burning building/car, wood burning stove in winter, suicide attempt
CO poisoning
Most important test in CHF
Echo
Best initial test for CHF
TTE
Most accurate test for CHF
MUGA
When would you use MUGA for CHF
Test for AE of doxorubicin for lymphoma Rx
When would you check BNP in CHF
Acute SOB w/ unclear etiology and cannot wait for echo
Normal BNP excludes CHF
Test if CHF etiology is from MI or heart block
EKG
Test if CHF etiology is from dilated cardiomyopathy
CXR
Test if CHF etiology is from paroxysmal arrhythmias
Holter
Test if CHF etiology is from valve/septal defects
Cath
Test if CHF etiology is from Anemia
CBC
Test if CHF etiology is from thyroid
T4/TSH
Test if CHF etiology is from infiltrative disease
Endomyocardial bx
Differentiate between CHF and ARDS
Swan-Ganz (not routine)
Decrease mortality in systolic dysfunction
ACEIs/ARBs
BBs
Spironolactone
Decrease sx in systolic dysfunction
Diuretics
Digoxin
Only BBs used in systolic dysfunction
Metoprolol
Bisoprolol
Carvedilol
How do BBs help in systolic dysfunction
Anti-ischemic
Decrease HR therefore decrease O2 consumption
Antiarrhythmic
MCC death from CHF
Arrhythmia
AE spironolactone
Gynecomastia - switch to eplerenone
Hyperkalemia
When to give diuretics in CHF
Initial therapy w/ low EF along with ACEI/ARB
What to do w/ hyperkalemia in CHF treatment
Switch ACEI to hydralazine and nitroglycerin
Sx digoxin tox
GI (MC)
CNS
Visual
Hyperkalemia
When to give implantable defibrillator in CHF
Ischemic cardiomyopathy w/ EF
When to give biventricular pacemaker
DIlated cardiomyopathy w/ EF 120ms
Mortality benefit in systolic dysfunction
ACEIs/ARBs BBs Spironolactone/Eplerenone Hydralazine/Nitrates Implantable defibrillator
Clear mortality benefit in diastolic dysfunction
BBs
Diuretics
Worst form of CHF
Pulmonary edema
Presentation of Pulm edema
Acute SOB Pink frothy productive cough Rales, JVD, S3 Orthopnea Edema
What are Kerley B lines on CXR
Fluid in septum
When to use BNP in pulm edema
SOB etiology is unclear
NL rules it out
CXR in pulm edema
Vascular congestion
LVH (chronic)
ABG results in pulmonary edema
Hypoxia
Most important test to do acutely in pulm edema
EKG
Fastest way to fix acute pulm edema from arrhythmia
Cardioversion
Contribution of atrial systole to CO
10-20%
Contribution of atrial systole to CO in the setting of dilated cardiomyopathy, decreased EF, valvular disease
40-50%
Best initial therapy of pulmonary edema
Diuretics to remove large fluid volumes
Preload reduction in pulm edema
Loops
O2
Morphine
Nitrates
When to use positive inotropes in pulm edema
Pt in ICU and not responding to diuretics
Dobutamine, Amrinone, Milrinone
When to give digoxin in pulm edema
Chronically to increase contractility esp w/ A-fib
Acute afterload reduction in pulm edema
Nitroprusside
IV hydralazine
Chronic afterload reduction in pulm edema
ACEIs/ ARBs
Main causes of regurgitant diseases
HTN
Ischemic heart disease
Best initial test for any valvular disease
Echo
Most accurate test for any valvular disease
Catheterization
Endocarditis PPx in valvular disease
Not indicated unless there has been replacement or previous endocarditis
MCC of MS
Rheumatic fever
Associations w/ MS
Pregnancy
Immigrants
Unique presenting features of MS
Dysphagia
Hoarseness
A-fib and stroke from enlarged LA → systemic emboli
Hemoptysis
Murmur in MS
Opening snap in diastole (after S2)
Loud S1
Common EKG findings in MS
A-fib
CXR in MS
Straightening of left heart border
Elevation of left main-stem bronchus
Second bubble behind heart
Rx MS
Diuretics, Na restriction - preload reduction
Balloon valvuloplasty - refractory/pregnant
Valve replacement - balloon contraindicated or fails
Warfarin for A-fib
Rate control for A-fib - digoxin, BBs, diltiazem/verapamil
Is pulm HTN a contraindication for surgery for MS
No
MCC AS
Congenital bicuspid
Calcification from aging
Presentation of AS
Angina (MC)
Syncope
CHF - poorest prognosis, 2yr survival
Murmur in AS
Systolic crescendo-decrescendo
Echo results in AS
Thick aortic leaflets
Decreased excursion
LVH
CXR and EKG findings in AS
LVH
Only true effective therapy in AS
Valve replacement when area
When to do balloon valvuloplasty in AS
Surgery contraindicated due to instability or fragility of pt
Cause of MR
Dilation of the heart
- HTN
- Endocarditis
- MI
- Papillary muscle rupture
Only unique physical finding in MR
Pan(holo)systolic murmur
Rest looks like CHF
Radiation of MR murmur
Axilla
Rx MR
Vasodilators - ACEIs/ARBs
Digoxin/diuretics
Valve replacement - LVSED >45 or EF
MCC AR
HTN
Causes of AR
Dilation of heart or aorta
- HTN
- MI
- Endocarditis
- Marfan, cystic medial necrosis
- Aortic dissection
- Ankylosing spondylitis/Reiter
- Syphilis
Unique PE findings in AR
Wide pulse pressure Watter hammer pulse Pulsating nail beds BP in legs > BP in arms Head bobbing
Murmur in AR
Diastolic decrescendo best heard at left lower sternal border
EKG/CXR findings in AR
LVH
Rx AR
Vasodilators - ACEIs/ARBs
Valve replacement - LVESD > 55, EF
Causes of MVP
Normal variant W>M
Marfan, Ehlers-Danlos
MC presentation of MVP
Atypical CP
Palpitations
Panic attack
Syncope
Murmur in MVP
Midsystolic click
Rx MVP
BBs if symptomatic
Valve repair
Endocarditis PPx in MVP
Not indicated
Murmurs increased w/ more blood to heart (Leg raise, squat)
MS, AS
MR, AR
Murmurs increased w/ less blood to heart (valsalva, standing)
MS, AS
MR, AR
Murmurs decreased w/ more blood to heart (Leg raise, squat)
HOCM
MVP
Murmurs decreased w/ less blood to heart (valsalva, standing)
HOCM
MVP
Murmurs that do NOT increase with expiration
HOCM
MVP
Rx for all types of cardiomyopathies
Diuretics
MCC dilated cardiomyopathy
Previous MI and ischemia
Other causes of dilated cardiomyopathy
Alcohol - 2nd MCC Postviral myocarditis Radiation Toxins Chagas Peripartum
Dx dilated cardiomyopathy
Echo then EKG, CXR
Shows decreased EF
Rx dilated cardiomyopathy
ACEIs/ARBs, BBs, spironolactone
Diuretics, digoxin
Biventricular pacemaker if QRS > 120ms
MCC hypertrophic cardiomyopathy
HTN
What is HOCM
Genetic disorder w/ abnormal shape of heart septum
Features specific to HCM
S4
Fewer RHF signs
MCC presentation of HOCM
Dyspnea
Other sx in HOCM
CP
Syncope
Sudden death
What worsens sx in HOCM
Anything increasing HR Anything decreasing LV size - ACEIs/ARBs - Digoxin - Hydralazine - Valsalva - Standing suddenly
Best initial test for HCM
Echo
Best initial therapy for HCM and HOCM
BBs
Most accurate test for HCM
Cath
Common EKG changes in HOCM
Septal Q waves
What to give in HOCM w/ syncope
Implantable defibrillator
Ultimate therapy in HOCM
Surgical myomectomy
Only after septal ablation is tried and meds fail
Hand grip increases
AR, MR
Hand grip decreases
AS
MVP
HOCM
Problem in restrictive cardiomyopathy
Heart doesn’t contract or relax normally
Causes of restrictive cardiomyopathy
Sarcoidosis Amyloid Hemochromatosis Endomyocardial fibrosis Scleroderma Cancer
MC complaint in restrictive cardiomyopathy
Dyspnea w/ RHF signs
Where do you see kussmaul’s sign
Restrictive cardiomyopathy
Constrictive pericarditis
Best initial test for restrictive cardiomyopathy
Echo
Most accurate test for restrictive cardiomyopathy
Endomyocardial Bx
Rx restrictive cardiomyopathy
Treat underlying cause
Diuretics may help
Which valvular diseases do diuretics help
MS, AS
MR, AR
MC infection causing pericarditis
Viral
MC connective tissue disease causing pericarditis
SLE
Presentation of pericarditis
Sharp CP changing in intensity w/ respiration and body position
Worse lying down
EKG in pericarditis
PR depression
ST elevation in all leads
Rx pericarditis
Treat underlying cause
Rx pericarditis if idiopathic cause
Presumed to be coxsackie B
NSAIDS - Steroids if they don’t work
Colchicine reduces recurrence
Any cause of pericarditis can cause
Pericardial tamponade
Common features of pericarditis
Hypotension
Tachy
Distended neck veins (not in PE)
Clear lungs
Physical finding in tamponade
Pulsus paradoxus
What is pulsus paradoxus
> 10mmHg decrease in BP on inspiration
Why should echo be done over EKG in tamponade
EKG commonly only shows tachy
EKG feature in tamponade
Electrical alternans
CXR feature in tamponade
Water bottle heart
Echo feature in tamponade
RA and RV diastolic collapse
Rx tamponade
Pericardiocentesis
IVF
Subxyphoid window in pericardium for recurrence
What is constrictive pericarditis
Any cause of pericarditis leading to calcification and fibrosis (can be from TB)
Sx indicating constrictive pericarditis
Signs of RHF
- Edema
- Ascites
- Hepatosplenomegaly
- JVD
Physical findings in constrictive pericarditis
Kussmaul sign - Increased JVD on inhalation
Knock - extra heart sound in diastole
Best initial test for constrictive pericarditis
CXR showing calcification and fibrosis
Rx Constrictive pericarditis
Diuretics FIRST
Surgical removal of pericardium
Causitive factors for PAD
DM
Hyperlipidemia
HTN
Smoking
Key sx in PAD
Leg pain in calves on exertion (intermittent claudication)
Pain walking up and down hills
Differentiate PAD from spinal stenosis in Hx
Stenosis is pain waling down hills only
Severe PAD is associated with loss of
Hair follicles
Sweat glands
Sebaceous glands
Skin looks smooth and shiny
Best initial test for PAD
ABI
Most accurate test for PAD
Angiogram
Best initial therapy for PAD
Aspirin
Stop smoking
Cilostazol
Single most effective medication for PAD
Cilostazol
Sx description in aortic dissection
Severe, Sharp, Tearing
Radiating through to back
Key points of aortic dissection
Loss of pulses +/- aortic insufficiency
BP difference b/w arms
Pain between scapulae
CXR feature in aortic dissection
Widened mediastinum
Most accurate test for aortic dissection
Angiography
However MRA = CTA = TEE
Best initial test for aortic dissection
CXR
Rx aortic dissection
Control BP
- BBs
- Nitroprusside
- Surgical correction
Most appropriate screening for aortic aneurysm
Surgical/Catheter repair when AAA > 5cm
Who doesn’t get screened for AAAs
Non-smokers
Women
Worst form of heart disease in pregnancy
Peripartum cardiomyopathy
- Abs against myocardium in pregnancy
If this isn’t a choice then Eisenmenger
Rx if LV dysfunction doesn’t improve
Cardiac transplant
Medical therapy of peripartum cardiomyopathy
ACEIs/ARBs BBs Spironolactone Diuretics Digoxin
Eisenmenger syndrome
R to L shunt from pulm HTN in people w/ VSD