Cardiac muscle (core skills) Flashcards

Describe the structure of cardiac muscle Understand the factors which affect cardiac muscle force generation Describe the metabolic requirements for contraction of cardiac muscle

1
Q

What type of pump is the heart?

A

Dual peristaltic

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2
Q

Which side of the heart is oxygenated?

A

Left

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3
Q

Which side of the heart is deoxygenated?

A

Right

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4
Q

Describe inotropy:

A

Increased force of contraction, increased stroke volume

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5
Q

Describe chronotropy:

A

Increasing frequency of contraction, increased heart rate

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6
Q

What is cardiac output?

A

The product of stroke volume and heart rate

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7
Q

What part of the cardiac muscle improves productivity?

A

Intercalated discs with desmosomes and a helical appearance

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8
Q

What do desmosomes do?

A

Allow for strong adherence and low resistance at gap junctions. This allows propagation of the action potential through the heart

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9
Q

On an ECG, what is the P wave?

A

Atrial depolarisation

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10
Q

On an ECG, what is the short delay after the P wave?

A

Atrioventricular node slows down

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11
Q

On an ECG, what is the QRS complex?

A

Ventricular depolarisation

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12
Q

On and ECG, what is the T wave?

A

Ventricular repolarisation

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13
Q

What is the AP propagated into

A

Into the myocyte

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14
Q

What is the calcium membrane store called?

A

Sarcoplasmic reticulum

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15
Q

What branches off the sarcoma, into the myocyte and what is their purpose?

A

T - tubules, which help excitation

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16
Q

Is a cardiac action potential shorter or longer than skeletal and why?

A

It is longer, this is due to the plateau which is a regulated pause for synchrony

17
Q

What ion is essential for cardiac contraction?

A

Sodium ions

18
Q

What causes the cardiac plateau?

A

An influx of calcium ions from the extra-cellular space to cytosol

19
Q

Why does the cardiac plateau occur?

A

The L-type calcium channels open for a long time

20
Q

What are the differences between skeletal and cardiac muscle calcium handlers?

A

Skeletal muscle has Thin t tubules, extensive SR and triads. Cardiac has the opposite, which t-tubules, limited SR and diads

21
Q

What energy source is used to power cardiac muscle?

A

ATP, lots of it due to never resting

22
Q

Where is the majority of the hearts ATP produced from?

A

Fatty acid and some glucose