Cardiac Cycle Flashcards

1
Q

What are the 3 basic events in the cardiac cycle

A

LV Contraction
LV Relaxation
LV Filling

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2
Q

What is systole

A

Ventricular contraction

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3
Q

What happens during systole

A

Wave of depolarisation arrives,pressure rises in the ventricle which causes the mitral valve to close and so the aortic valve opens and ejection of blood begins

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4
Q

What is diastole

A

Ventricular relaxation

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5
Q

What happens during diastole

A

The ventricular pressure decreases, the ventricle goes through a phase of reduced ejection but the aortic flow is maintained due to distension, eventually the aortic valve will close and isovolumic relaxation will occur before the mitral valve opens agin to begin refilling

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6
Q

How does ventricular filling occur

A

The ventricles fill due to the mitral valve opening caused by increased pressure which exceeds that of the ventricles and so rapid filling starts.

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7
Q

When does ventricular filling stop

A

Ventricular filling stops when diastasis is reached, this is when the pressure in the atria and ventricles is equal, this is only a temporary stop

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8
Q

How is ventricular filling restored after diastasis

A

Filling is renewed when a contraction used as a booster raises the atria pressure again and so the pressure gradient been present again

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9
Q

Apart from the pressure gradient what else can cause rapid ventricular filling

A

Ventricular suction

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10
Q

What is preload

A

Preload is the load present before left ventricular contraction has started

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11
Q

What is after load

A

After load is the load after the ventricle starts to contract

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12
Q

What is starlings law of the heart

A

Within physiologic limits the larger the volume of the heart the greater the energy of its contraction and the amount of chemical change at each contraction

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13
Q

What is LV filling pressure

A

LV pressure is the difference between the Left Atrial pressure and the left ventricular diastolic pressure

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14
Q

Explain the force-length interaction and starlings law

A

The force which is produced by the skeletal muscle declines when the sarcomere is less than optimal length so in the cardiac sarcomere at 80% of the optimal length only 10% of the maximal force is produced

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15
Q

Explain all or none in the cardiac sarcomere

A

The cardiac sarcomere must function near the upper limit of their maximal length- 2.2um
The left ventricular volume changes are affected when the sarcomere lengthens from 85% to the full LMAX

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16
Q

How is a positive inotropic effect put on the heart

A

The heart can during the cycle increase and decrease the pressure even if the volume is fixed. Increasing the diastolic heart volume leads to increased velocity and force of contraction in line with franks law

17
Q

What is contractility

A

Contractility is the state of the heart which enables it to increase its contraction velocity to achieve higher pressure when the contractility is increased independent of load

18
Q

What is elasticity

A

Elasticity is the myocardial ability to recover its normal shape after removal of systolic stress

19
Q

What is compliance within the myocardium

A

Compliance is the relationship between the change in stress and the resultant strain

20
Q

What is diastolic distensibility

A

Diastolic distensibility is the pressure required to fill the ventricle to the same diastolic volume

21
Q

What does the pressure-volume loop reflect

A

The pressure-volume loop reflects contractility in the end-systolic pressure volume relationship, while compliance is reflected at the end diastolic pressure volume relationship

22
Q

Where can isometric conditions be found

A

Isometric conditions can be found during isovolumic contraction

23
Q

Why can’t isotonic contraction be seen in the heart

A

Isotonic contraction is totally impossible in the heart due to constantly changing load