Cardiac Flashcards
What is the mechanism of action and classification of Heparin?
Class: anticoagulant
MOA: inhibits factor Xa
What are potential causes for pericarditis?
- viruses (most common cause)
- MI
- cardiac surgery
- rheumatic fever
- neoplasia
- radiation therapy
- uremia
- tuberculosis (TB)
- idiopathic
- trauma
- drugs
What viruses are the most common cause(s) of pericarditis?
- coxsackie virus
- echoviruses
- Epstein-Barr
- influenza
- hepatitis
- varicella
- mumps
What are the s/s of pericarditis?
- precordial/retrosternal, localized, pleuritic chest pain
- Chest Pain worse with cough, swallowing, inspiration
- Chest Pain relieved by sitting forward
- dyspnea
- pericardial friction rub
A pericardial friction rub heard when auscultating heart sounds is indicative of what?
pericarditis
What ECG changes are associated with pericarditis?
- depressed PR interval (diagnostic)
- ST concave (smile) elevation in multiple leads
What lab findings are associated with pericarditis?
- leukocytosis = high WBC
- elevated erythrocyte sedimentation rate (ESR) = inflammation
1) < 50 y/o- Male > 15 mm/hr
- Female > 20 mm/hr
2) > 50 y/o - Male > 20 mm/hr
- female > 30 mm/hr
How is the diagnosis of pericarditis confirmed?
- depressed PR interval on ECG
- elevated ST concave shaped interval (smile)
- echocardiogram to confirm pericardial fluid
What is the treatment/management for pericarditis?
- colchicine (anti-inflammatory)
- NSAIDs
- proton pump inhibitor d/t risk of Gi toxicity
- corticosteroids only if NSAID use is contraindicated or has failed
- antibiotics (bacterial infections)
- monitor for cardiac tamponade
- Vicodin (PRN for pain)
Vicodin is a combination of what drugs?
hydrocodone and acetaminophen
what is the name of the medication that has hydrocodone and acetaminophen?
Vicodin
Why is colchicine used in the treatment of patients with atherosclerotic disease or with multiple risk factors for cardiovascular disease?
- reduces risk of the below by:
- reducing high-sensitivity C-reactive protein
- prevents the activation, degranulation and migration of neutrophils which causes an anti-inflammatory effect
- MI
- stroke
- cardiovascular death
What are the most common causes of endocarditis?
- bacteria are most common cause
- staphylococcus aureus (gram pos)
- streptococcus pyogenes (gram pos)
- pneumococcus (gram pos)
- neisseria orgasms (gram neg)
What is the most common predisposing risk factor for endocarditis?
invasive procedures
- dental surgery
- GU surgery
- catheter placement
- HD
- burn treatment
What are the s/s of endocarditis?
- signs of infection
- splenomegaly
- pallor
What lab findings are associated with endocarditis?
- normochromic, normocytic anema
- leukocytosis with a left shift
- WBC bands present
- elevated erythrocyte sedimentation rate
What is normochromic, normocytic anemia?
type of anemia where the RBCs are the normal in size, shape and color
What tests should be done in a patient that presents with s/s of endocarditis?
- blood cultures (3 from different sites)
- echocardiogram to assess valvular involvement (presence of vegetation)
- BMP
- erythrocyte sedimentation rate
- CBC
What is the treatment/management for endocarditis?
- infectious disease consult
- empiric AB therapy that covers gram positive bacteria while waiting for cultures
What is the normal ejection fraction range?
50-70%
What are causes of HFrEF?
- ischemic heart disease (ex. CAD), myocardium can’t get enough O2
- MI, heart is damaged
- cardiomyopathy, thickened or scarred myocardium = less contractility
- aortic stenosis, decreased CO
- mitral regurgitation, decreased CO
- arrhythmias, ineffective pumping
- myocarditis, inflammation = low CO
What are risk factors/causes of HFrEF?
- age, vessels are less elastic
- obesity
- HTN
- DM type II
- CAD
- CKD
- COPD
- sleep apnea
- anemia
What are the NYHA functional classifications?
- class I: no symptoms/limitations
- class II: symptoms with moderate exertion
- class III: symptoms with any activity
- class IV: symptoms at rest
What are AHA stages of heart failure?
- Stage A: high risk, no structural disease
- Stage B: structural disease, no symptoms
- Stage C: structural disease w/ s/s
- Stage D: refractory HF, s/s at rest
What is the mortality rate r/t a diagnosis of heart failure?
50% mortality rate within 5 years of diagnosis
What is the most common cause of chronic heart failure?
LV dysfunction r/t coronary artery disease
What is the most common cause of acute heart failure?
HTN