Carcinogenesis Flashcards
what is the source of aflatoxin and what is the associated cancer?
derived from aspergillus (improperly stored grains) and causes hepatocellular carcinoma
polycyclic hydrocarbons
source?
cancers?
cigarettes, smoked fish/meats
squamous cell or small cell carcinoma, urothelial carcinoma
b-napthylamine
source?
cancers?
dye or rubber
bladder cancer (urothelial)
mitrosamine
source?
cancers?
food preservatives
gastric carcinoma
asbestos
source?
cancers?
pipe fitters and ship builders
mesothelioma, lung cancer
vinyl chloride
source?
cancer?
plastics, PVC plastic for pipes
angiosarcoma of liver
chromium and nickel
bronchogenic carcinoma
arsenic
skin cancer
smoking
oral cavity, mid esophagus, larynx, lung cancers
alcohol
oropharynx, pancreatic an dhepatocellular carcinomas
Nickel
lung
radon
lung
Diethyl-Stilbesterol (DES
celar cell carcionooma of vagina
oral contraceptives
liver adenoma
UVB 280-320 aka UV radiation
formation of pyrimiddine dimers leads to DNA damage and NER damaged so you can get xerodermapigmentosa