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Mini II > Carcinogenesis > Flashcards

Carcinogenesis Flashcards

1
Q

what is the source of aflatoxin and what is the associated cancer?

A

derived from aspergillus (improperly stored grains) and causes hepatocellular carcinoma

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2
Q

polycyclic hydrocarbons

source?
cancers?

A

cigarettes, smoked fish/meats

squamous cell or small cell carcinoma, urothelial carcinoma

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3
Q

b-napthylamine

source?
cancers?

A

dye or rubber

bladder cancer (urothelial)

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4
Q

mitrosamine

source?
cancers?

A

food preservatives

gastric carcinoma

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5
Q

asbestos

source?
cancers?

A

pipe fitters and ship builders

mesothelioma, lung cancer

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6
Q

vinyl chloride

source?
cancer?

A

plastics, PVC plastic for pipes

angiosarcoma of liver

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7
Q

chromium and nickel

A

bronchogenic carcinoma

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8
Q

arsenic

A

skin cancer

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9
Q

smoking

A

oral cavity, mid esophagus, larynx, lung cancers

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10
Q

alcohol

A

oropharynx, pancreatic an dhepatocellular carcinomas

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11
Q

Nickel

A

lung

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12
Q

radon

A

lung

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13
Q

Diethyl-Stilbesterol (DES

A

celar cell carcionooma of vagina

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14
Q

oral contraceptives

A

liver adenoma

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15
Q

UVB 280-320 aka UV radiation

A

formation of pyrimiddine dimers leads to DNA damage and NER damaged so you can get xerodermapigmentosa

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16
Q

atomic bomb will give you?

A

leukemias (but not CLL), thyroid cancer

17
Q

CT scans in children give you?

A

leukemia and brain tumors

18
Q

Hep B virus (HBV)

MOA
Cancer
Features

A

1) chronic inflammation with hepatocyte death producing genotoxic and mutagenic mediators
2) hepatocellular carcinoma
3) chronic liver cell injury and regenerative hyperplasia (cirrhosis)

19
Q

EBV

MOA
Cancer
Features

A

1) polycolonal B cell rpofliferation increases risk of t(8:14) translocation
2) burkitt lymphoma, hodgkin, CNS B cell lymphoma in AIDS, Nasopharyngeal carcinoma

3) “starry sky appearance”

20
Q

HPV

MOA
Cancer
Features

A

1) e6 inhibits P53, E7 inhibits RB
2) squamous cell carcinoma
3) low risk = 6 and 11
high risk = 16, 18, 31

21
Q

HHV-8

MOA
Cancer
Features

A

1) infection of epithelial cells
2) kaposi sarcoma in AIDS
3) lesions filled with endothelial cells

22
Q

HTLV-1

MOA
Cancer
Features

A

1) activation of TAX
2) T cell leukemia and lymphoma
3) Japan, Caribbean

23
Q

Hep C

MOA
Cancer
Features

A

1) chronic liver cell injury, compensatory regeneration

2) hepatocellular carcinoma

24
Q

HIV

MOA
Cancer
Features

A

1) polyclonal B cell activation to monoclonal B cell activation
2) primary CNS lymphoma, high grade B cell lymphoma

25
Q

H. pylori

MOA
Cancer
Features

A

1) CagA

2) stomach cancer

26
Q

shistosoma hematobium

A

squamous cell carcinoma or urinary bladder

Mini II (17 decks)

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