Carbohydrates and molarity Flashcards
How to chemical changes effect carbohydrates
Affects their function and the way the body uses them, the react differently with other molecules meaning they have different properties.
Glycosylation
In post translational modification oligosaccharides can be added to proteins. They can regulate protein function, can be O-linked (oxygen) or N-linked (nitrogen), Aids in folding and processing of protein, alters its ability to interact with other cell macromolecules.
Functions of glycosylation
They are involved in protection (mucin), recognition, adhesion, structural (collagen), and cell communication.
Three classes of glycoproteins
simple glycoproteins (mainly protein), mucins (mainly carbohydrate), proteoglycans (mainly carbohydrate).
Glycosylation diseases
Diseases can be caused when there is a mutation in the enzyme involved in glycosylation meaning the process does not take place. Can cause developmental delay and seizures.
Mucus function
Forms a protective layer on epithelial surfaces. Traps foreign particles and bacteria, when swallowed they are destroyed in stomach acid. In the digestive tract it lubricates and protects the stomack lining from the acid
Mucin structure
Mucin forms a part of mucus. The proteins backbone in mucin is highly O-glycosylated, it is also hygroscopic meaning it attracts and retains H2O. There is a D-domain either side of the protein backbone this allows the mucin to form disulphide bonds with other mucin molecules. The disulphide bonds allow for polymerisation which allows the formation of a hydrated gel lattice, as the glycosylation allows it to hold a lot of water.
Basic empirical formula of carbohydrates
(CH2O)n
Groups sugars can be defined by
Aldehydes-aldoses
Ketones-ketoses
Oligosaccharides
Carbohydrates are between 2 or 10 simple sugars
Disaccharides
Two monosaccharides joined by a glycosidic bond.
Glycosidic bond
Formed in a condensation reaction. Bond is named after the carbons which join up i.e. a 1-6 glyocsidic bond. Alpha and beta glycosidic bond, in beta the sugar molecule is switched upside down.
Starch
Type of polysaccharide. It is made of amylose (alpha 1,4 glycosidic bonds) and amylopectin (alpha 1,6 glycosidic bonds), which generates branching. It is very dense, and the branching means that it is easily broken down.
Cellulose
Beta 1,4 linked D glucose, very rigid forms structural component in plants. Insoluble and hard to digest.
Glycogen
Stores most glucose in humans. Mainly alpha 1,4 glycosidic bonds with some alpha 1,6 glycosidic bonds which allow for branching so it can be rapidly broken down