Carbohydrates 1 Flashcards

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1
Q

Why are Carbs a major energy source?

A

Theyre highly oxidisable beacuse of ‘high energy’ H atom-associated electrons.

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2
Q

How do carbohydrates have structural and protective functions?

A

In plants cellulose is critical to cell walls

In animals carbs form part of the ECM

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3
Q

How do carbs contribute to cell-cell communication?

A

They make up ABO blood groups.

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4
Q

How are disaccharides formed>

A

From monosaccharide momomers linked by a glycosidic bond. The OH group of one binds to the anomeric carbon of another.

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5
Q

What monomers make up Maltose?

A

2 Glc monomers

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6
Q

What monomers make up Lactose?

A

One Glc and one galactose

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7
Q

What monomers make up sucrose?

A

Glucose and Fructose (only one with no free anomeric carbon so no oxidation)

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8
Q

In what 4 waus are polysaccharides distinguished?

A
  • reccuring monomer units
  • Length of chains
  • Types of bonds linking monosaccharides units
  • AMount of branching
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9
Q

Define homo- and hetero- polysaccharides

A

homopolysaccharides have a single monomeric species

heteropolysaccharides have 2 or more

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10
Q

Name the 2 glucose polymers that make up starch an explain the difference:

A

Amylose and Amylopectin

amylopectin is branched

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11
Q

Why store glucose in starch as polymers?

A

for compactness and because they have many non-reducing ends allowin rapid synthesis and degradation

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12
Q

qWhy store glucose in glycogen as polymers?

A

Compactness
Rapid syntheis and degradation due to many non-reducing ends
Polymers form hydrated gels that are osmotically inactive stopping Glc from diffusing out of cells into the blood.

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13
Q

Name 4 effect sof carbs attached to proteins (glycoproteins)

A
  • increased protein solubility
  • influence protein conformation
  • protect from degradation
  • inter-cellular communication (cell signalling and recognition)
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14
Q

Where are glycoproteins found?

A

Mainly outer plasma membrane and ECM.
Also Blood and withing secretory system of cells (golgi body)
Occasionally as cytoplasmic or nuclear proteins.

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15
Q

What are glycosamioglycans? (GAGS)

A

“mucopolysaccharides”

Unbranched polymers of hexuronic acid and a repeating sugar

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16
Q

What forms proteoglycans?

A

GAGS covalently attached to proteins.

17
Q

Where are proteoglycans found and in what type of tissue?

A

Macromolecules on cell surface or ECM.

Connective Tissue.

18
Q

What are mucopolysaccharidoses?

A

Genetic disorders caused by abscence or malfunction of enzymes that break down GAGS

19
Q

What does it cause?

A

Build up of GAGS in connective tissue, blood and brain.

Can cause dementia, heart problems and problems with any endothelial structure.

20
Q

Examples of mucopolysaccharidoses?

A

Hurler, Schie, hunter and sanflippo syndromes.

21
Q

how are mucopolysaccahridoses treated?q

A

Experimental therapies incuding gene therapy and enzyme replacement therapy.