Cancer of Unknown Primary Flashcards
Name cancers that are CK7 and CK20 positive?
Urothelial
Ovarian and primary peritoneal carcinoma
Pancreatic
Cholangiocarcinoma
Name cancers that are CK7 and CK20 negative
HCC
RCC
Prostate
Squamous cell carcinoma
Melanoma
What markers are you likely to see in ovarian/PPC?
PAX8, WT1
Which markers are you likely to see in RCC?
RCC and PAX8
Which markers are you likely to see in melanoma?
S100 and Melon A
Name cancers likely to CK7 positive and CK20 negative
Lung
Thyroid
Breast
Cervical
Endometrial
Pancreatic (CK 19)
Cholangiocarcinoma (CK 19)
Name 3 markers in Breast cancer
ER/PR, GCDFP-15, GATA 3
Name cancers likely to CK7 negative and CK20 positive
CRC and Merkel cell cancer. Share the same markers of CEA and CDX2
Which cancers are likely to be CK5/6 positive
Squamous cell lung cancer and mesothelioma
First line treatment for adenocarcinoma of unknown primary?
Carboplatin and paclitaxel
First line treatment for SqCC of unknown primary?
Carboplatin and gemcitabine or paclitaxel
When should PET-CT be used for staging in CUP?
Female with axillary lymphadenopathy and where radical treatment proposed and other imaging and histology has failed to demonstrate a primary site.
What should be considered in patients with midline lymph node involvement?
Germ cell and lymphoma
What proportion of CUP belong to a favourable sub group?
20%
What are the features of H&N like CUP?
SqCC with non SCF cervical lymph nodes
