Cancer Immunotherapy

Question 1

Treating Cancer

Answer 1

• Surgery, remove tumor
• Radiation and chemotherapy, destroy rapidly dividing cells.
• Newer approaches are targeted to specific mutations in cancer cells. Disrupt cell cycle/ alter immune to destroy cancer cells.

Question 2

Cancer Immunotherapy

Answer 2

Enhance the power of the host immune
system for the treatment of malignancy

Question 3

Coley’s toxins

Answer 3

William Coley found a way to destroy tumors by injecting patients with toxic bacteria.

Question 4

Immune Checkpoint Inhibitors

Answer 4

Drugs that release the brake on the immune system, telling them to attack cancer cells.
EX: CTLA-4, PD-1, PD-L1

Question 5

Chimeric Antigen Receptor Therapy (CAR T)

Answer 5

-Replace T Cell Receptor
- Improves the ability of the immune system to recognize and destroy cancer cells

Question 6

CAR T step

Answer 6

1. Remove blood to get T cells
2. Insert gene for CAR T in the lab
3. Grow CAR T cells
4. Infuse to patient
5. CAR T cells kill cancer cells

Question 7

Design of CAR T

Answer 7

• The antigen binding site typically derived from monoclonal antibody