cancer drugs

Question 1

FRONT

Answer 1

BACK

Question 2

This class of cancer drug is cell-cycle non-specific and substitutes and alkyl group for a hydrogen atom which results in interference of DNA replication and RNA transcription:

Answer 2

alkylating agents

Question 3

An example of an alkylating agent is:

Answer 3

cisplatin

Question 4

T or F: A patient taking cisplatin will liekly experience mucositis and esophagitis.

Answer 4

FALSE

Question 5

Patients taking this drug commonly experience severe nausea and vomiting, as well as a metallic aftertaste in their mouths

Answer 5

cisplatin

Question 6

Antitumor antibiotics mechanism of action is:

Answer 6

inhibiting cell division by binding to DNA and interfering with RNA transcription

Question 7

An example of an antitumor antibiotic is:

Answer 7

doxorubicin

Question 8

A person taking doxorubicin is not likely to experience:

Answer 8

renal or hepatic toxicity

Question 9

Patients that complain of an abnormal dryness of the mouth (xerostomia) are most likely taking:

Answer 9

doxurubicin

Question 10

Drugs that interfere with nucleic acid synthesis by substituting drug for purines or pyrimidines necessary for normal cellular function are:

Answer 10

Antimetabolites

Question 11

A patient taking an antimetabolite drug who is having difficulty with vitamin B12, fat and D-xylose absorption, has renal and hepatic toxicity, and change in taste acuity is taking:

Answer 11

methotrexate

Question 12

When a patient is taking __________________ they should avoid pyridoxine supplementation

Answer 12

fluorouracil

Question 13

A patient taking an antimetabolite drug and is experiencing moderate vomiting, anorexia, severe mucositis and esophagitis, diarrhea, and hepatic toxicity. Clinical tests reveal no sign of renal toxicity. The drug is:

Answer 13

fluorouracil

Question 14

Hormones/hormone modifier drugs work by:

Answer 14

altering cellular metabolism by changing body hormonal milieu for unfavorable tumor growth

Question 15

List one hormone used for treating cancer:

Answer 15

glucocorticoids

Question 16

A person taking glucocorticoids may experience mild nausea and vomiting T or F:

Answer 16

TRUE

Question 17

hyperpagia, sodium and fluid retention, gastrointestinal upset, glucose intolerance, K+ wasting, osteoporosis, and negative nitrogen balance are all sides effects of:

Answer 17

glucocorticoids

Question 18

This class of cancer drug works by inhibiting mitotic spindle formation and blocking mitosis:

Answer 18

Plant alkaloids

Question 19

Liat an example of a plant alkaloid drug:

Answer 19

vincristine

Question 20

A person experiencing mild vomiting, anorexia, mucositis and esophagitis, alternating constipation and diarrhea, and hepatic toxicity is taking:

Answer 20

vincristine

Question 21

What is one hallmark side effect of vincristine?

Answer 21

hyponatremia (abnormally low level of sodium in the blood)

Question 22

Interferon is a biologic response modifier that works by:

Answer 22

modifying host biologic responses to tumor

Question 23

A noticible weight change (increase or decrease)can be associated with which drug?

Answer 23

interferon

Question 24

A person taking interferon is NOT likely to experience:

Answer 24

mucositis & esophagitis and renal toxicity

Question 25

T or F: A patient taking interferon will most likely experience severe vomiting.

Answer 25

FALSE

Question 26

Renal tubular necrosis is associated with taking:

Answer 26

cisplatin

Question 27

Methotexate can have what effect on the liver?

Answer 27

It can cause hepatic fibrosis

Question 28

Fluid retention is a common side effect for:

Answer 28

glucocorticoids

Question 29

Both alkylating agents and antitumor antibiotics interfere with DNA and RNA transcription. What is the difference between the two?

Answer 29

alkylating agents work by substituting an alkyl group for a hydrogen atom which interfers with DNA replication, while antitumor antibiotics bind to DNA and inhibit cell division

Question 30

A side effect of Cisplatin may be the decrease of which 3 minerals?

Answer 30

Serum magnesium, potassium, and zinc