anti-inflammatory drug-C

Question 1

List the three main classes of anti-inflammatory drugs

Answer 1

salicylates, Non steroidal antiinflammatory drugs, corticosteroids

Question 3

What is the mechanism of action for salicylates (subclass of NSAIDS)?

Answer 3

inhibit synthesis of protaglandins

Question 5

What is the mechanism of action for NSAIDS?

Answer 5

inhibit synthesis of protaglandins

Question 7

What is the mechanism of action for corticosteroids?

Answer 7

block arachidonic acid, decrease production of prostiglandins and leukotrienes

Question 9

What is the funtion of cyclooxygenase-1 (COX-1)?

Answer 9

reduces gastric-acid secretion, promotes renal blood flow, promotes platelet aggregation

Question 11

What happens when COX-1 I inhibited?

Answer 11

bleeding, gastric upset, reduced renal funtion

Question 13

What is the purpose of COX-2?

Answer 13

promotes inflammation, sensitizes pain receptors, mediates fever in brain

Question 15

What happens when COX-2 is inhibited?

Answer 15

suppression of inflammation

Question 17

____________ is found in ALL body tissues, while _________ is only present at sites of injury.

Answer 17

COX-1, COX-2

Question 19

___________ are the newest and most controversial class of anti-inflammatory drugs

Answer 19

COX-2 inhibitors

Question 21

T or F: COX-2 inhibitors also inhibit COX-1

Answer 21

FALSE: Cox-2 inhibitors inhibit COX-2 only

Question 23

____________ are the treatment of choice for moderate to severe inflammation.

Answer 23

COX-2 inhibitors

Question 25

What is the only remaining COX-2 inhibitor on the market?

Answer 25

celebrex

Question 27

What is a well-known prototype in the salicylates class?

Answer 27

aspirin

Question 29

Aspirin works by:

Answer 29

treating inflammation by inhibiting both COX-1 and COX-2 (inhibiting prostaglandin synthesis)

Question 31

What are some adverse reactions to aspirin?

Answer 31

bleeding and GI irritation, renal and hepatic toxicity

Question 33

What can occur in children and teenagers with acute febrile illness who are given aspirin ?

Answer 33

reye syndrome

Question 35

T or F: acetaminophen (tylenol) is an NSAID.

Answer 35

FALSE!!! Has NO anti-inflammatory action!

Question 37

What are the primary drugs given to treat mild to moderate inflammation?

Answer 37

NSAIDS

Question 39

The NSAID class includes which 3 main drugs?

Answer 39

aspirin, ibuprofen, COX-2 inhibitors

Question 41

Prednisone is an example of a______________ which is in the ____________ class.

Answer 41

corticosteroid, glucocoticoid

Question 43

Prednisone decreases inflammation by:

Answer 43

decreasing formation, release, and activity of endogenous mediators of inflammation and modifying the body’s immune response

Question 45

What are some serious adverse effects of prednisone?

Answer 45

adrenal suppression, psychosis, hyperglycemia

Question 47

T or F: Before administering a NSAID, baseline kidney and liver function tests as well as a CBC should be performed

Answer 47

TRUE

Question 49

While a patient is on NSAIDS, a nurse should be assessing for 3 main things:

Answer 49

1. GI bleeding 2. Changes in pain as well as reduction in temperature and inflammation 3. assess for adverse side effects such as nephrotoxicity, hemolytic anemia, salicylate toxicity

Question 51

What is the mechanism of action for antipyretic drugs?

Answer 51

reduce fever by direct action on the hypothalamic heat-regulating center

Question 53

What is the prototype drug in the antipyretic class?

Answer 53

acetaminophen (tylenol)

Question 55

What is the primary use of tylenol?

Answer 55

to relieve pain and reduce fever-NO ANTI INFLAMMATORY ACTIONS!

Question 57

What is an adverse effect of tylenol?

Answer 57

possible liver damage