Cancer drugs Flashcards
Vinca Alkaloids work in:
M Stage. They are non-specific.
Vinca Alkaloids examples
Vinblastine, Vincristine, Vinorelbine
Antimetabolites work in:
S stage. They are specific
Antimetabolites Examples
Antimetabolites Mitotic inhibitors Alkaloid topoisomerase II inhibitors Topoisomerase I inhibitors Antineoplastic enzymes
When cell cycle-specific drugs work
When Cell is diving
Hydroxyurea hallmarks
Antimetabolite, PO, black nails.
Methotrexate hallmarks
Immunosuppressive and antiinflammatory activity. Stop folic acid supplements, DON’T take Warfarin while in this drug, Leucovorin “rescue” med,
Mitotic Inhibitors
Used to treat a variety of solid tumors and some hematologic malignancies. Testicular, small-cell lung, breast, ovarian, non–small-cell lung cancers, Kaposi’s sarcoma, Acute leukemia
Vincristine
Mitotic Inhibitor, decrease Dig and phenytoin doses, burning brain, hepatotoxic, paralytic ileus.
Paclitaxel
Cardiotoxic, bronchospasm (premedicate), loose nails,
Topoisomerase Inhibitors (specific)
Does not cross blood brain barrier, It can cause cardiac issues,
Etoposide
Lung CA, testicular Prolongs INR Anaphylaxis Renal and hepatic impairment Alopecia 2/3 Metal taste Head aches.
Topotecan
Ovarian, colon small cell lung ca
Do not give filgrastin until 24 hours after dose
NVD (nausea, vomiting, diarrhea.
Hematuria. Hemorrhagic cystitis.
Alkylating Agents (Cyclophosphamide)
Widely used, can cause hemorrhagic cystitis
Protect bladder with Mesna, fluids, PH checks
Cardio and nephrotoxic, myelosupression 7-14 days
N&V 2-4 hours lasting 24
Decreases dig and phenytoin levels
Increases anticoagulant effect
Needs bicarb stand by.
Carboplatin (Alkulating agents)
Ovarian, testicular, bladder head and neck cancers, leukemia's Renal, liver, ototoxicty. Nausea and delayed nausea Peripheral neuropathy Alopecia is rare.
