Cancer

Question 1

What type of molecule is Ras?

Answer 1

GTPase

Question 2

What type of molecule is Myc?

Answer 2

Transcription factor

Question 3

What type of molecule is EGFR?

Answer 3

Tyrosine kinase

Question 4

What type of molecule is p53?

Answer 4

Transcription factor

Question 5

What normally inhibits p53?

Answer 5

mdm2

Question 6

What does p53 activate?

Answer 6

p21

Question 7

What does p21 inhibit?

Answer 7

Cyclin E and cdk2

Question 8

What does p16 inhibit?

Answer 8

Cyclin D and cdk4

Question 9

What inhibits Rb?

Answer 9

cdk4 and 6

Question 10

What does telomerase do?

Answer 10

Rebuilds telomeres to gives cells limitless regenerative capacity

Question 11

Free isotopes for radiotherapy

Answer 11

Gallium

Iodine 131

Question 12

Alkylators

Answer 12

Induce DNA damage
Platinums
Cyclophosphamide

Question 13

Vinca alkyloids

Answer 13

Inhibits spindle formation

Question 14

Taxanes

Answer 14

Inhibit spindle disassembly

Question 15

Topoisomerase inhibitors

Answer 15

Anthracyclines

Etopside

Question 16

Anti-CD52

Answer 16

Alemtuzumab

Question 17

Anti-CD20s

Answer 17

Rituximab
Obintuzumab
Ocrelizumab
Tositumomab

Question 18

SERM example

Answer 18

Tamoxifen

Question 19

mTOR inhibitor

Answer 19

everolimus

Question 20

Retinoic acid MoA

Answer 20

Translocation inhibitor

Question 21

Thalidomide MoA

Answer 21

Anti-angiogenic

Anti-proliferative

Question 22

Chromosomal abberations

Answer 22

Rearrangements
Insertions
Deletions

Question 23

Genomic abberations

Answer 23

Euploid = different number of sets of chromosomes
- triploidy = 69 chromosomes
Aneuploidy = different number of individual chromosomes
- Down syndrome = trisomy 21

Question 24

What activates BAX?

Answer 24

p53

Question 25

Bcl-2 proteins

Answer 25

Anti-apoptotic proteins = Bcl-2, Bcl-x

Pro-apoptotic proteins = BAX, Bak