Cancer Flashcards
1
Q
What type of molecule is Ras?
A
GTPase
2
Q
What type of molecule is Myc?
A
Transcription factor
3
Q
What type of molecule is EGFR?
A
Tyrosine kinase
4
Q
What type of molecule is p53?
A
Transcription factor
5
Q
What normally inhibits p53?
A
mdm2
6
Q
What does p53 activate?
A
p21
7
Q
What does p21 inhibit?
A
Cyclin E and cdk2
8
Q
What does p16 inhibit?
A
Cyclin D and cdk4
9
Q
What inhibits Rb?
A
cdk4 and 6
10
Q
What does telomerase do?
A
Rebuilds telomeres to gives cells limitless regenerative capacity
11
Q
Free isotopes for radiotherapy
A
Gallium
Iodine 131
12
Q
Alkylators
A
Induce DNA damage
Platinums
Cyclophosphamide
13
Q
Vinca alkyloids
A
Inhibits spindle formation
14
Q
Taxanes
A
Inhibit spindle disassembly
15
Q
Topoisomerase inhibitors
A
Anthracyclines
Etopside
