CAMTASIA: Thyroid Epithelial Transport

Question 1

How does iodide enter the follicular epithelial cell of the thyroid?

Answer 1

Active iodide uptake. Symport with Na+

Question 2

What forms the backbone of thyroglobulin within the follicular epithelial cell of the thyroid?

Answer 2

Tyrosine

Question 3

Within the lumen, adding a single tyrosine to the ____ molecule will form ____ and ____

Answer 3

Iodine, MIT, DIT

Question 4

T/F T3, T4, DIT and MIT are all put into circulation from the follicular epithelial cell of the thyroid?

Answer 4

FALSE. Only T3 and T4. DIT and MIT remain in the cell.

Question 5

What are two ways to prevent T3 and T4 from getting into circulation?

Answer 5

Block the iodide/Na+ symporter or inhibit the peroxidase that breaks things down into T3 and T4 within the lumen so there is none to be released.

Question 6

How does iodide become iodine within the lumen?

Answer 6

Peroxidase