CABS: ILD Flashcards
Zone 1 of lungs -
alveolar pressure is greater than capillary thus collapsing it
Zone 2 of lungs -
above the LA the alveolar pressure > venous but not arterial
Zone 3 of lungs -
base, low alveolar pressure, higher vasculature pressure, alveolar more compliant
ILD leads to pulmonary fibrosis where
in the parenchyma
Airspace vs ILD
airspace - alveolar disease
ILD - infiltrative disease leading to fibrosis of the lungs
ILD is a ______ disorder
progressive
Idiopathic Pulmonary fibrosis causes
start of process not clear
likely associated with:
smoking, GERD, pollution
IPF is loss of
type 1 epithelial cells (structure)
Type 2 overgrowth leads to
not allowing for repair/ regrowth of the damaged epithelium
IPF on CXR, HRCT will see
basilar opacities, honeycombing
IPF may require ____ for dx
bx
pneumoconiosis is m/c associated with what causative agents
silica, asbestos, coal
Presentation of pneumoconiosis
cough
dyspnea
diminished lung volumes
progress to hypoxemia
Coal workers pneumoconiosis m/c occurs in pts
who work >20 yrs in coal mine
specifically high carbon coal - may contain silia
Black masses m/c in the (what fields)
upper posterior lung fields
Presentation of pneumoconiosis
melanoptysis**
cough
progressive dyspnea
pulm HTN
RV failure
Silicosis associated with what causative agents
inhalation of crystalline silica
Silicosis has deposition of silica dust where
within the terminal bronchioles and alveoli
direct toxic reaction to the silica =
breaks down type 2 cells
Asbestosis is
silicate which was used industrially for construction
Asbestos is found in
old homes ships and mines
Asbestosis forms _____ years after exposure
15 years
Asbestos causes
direct lung injury d/t fiber microtrauma
Sarcoidosis is a ________ disease
granulomatous
On exam in sarcoidosis shows
non-caseating granulomas
may appear similar to TB or fungal infections
Sarcoidosis causes destruction of the
capillary perfusion membrane, formation of granulomas, inflammation
Hypersensitivity Pneumonitis is when
parenchymal inflammation secondary to immune reaction to inhaled noxious stimuli
m/c subtype of Hypersensitivity Pneumonitis
farmer’s lung
Clubbing is a result of
chronic hypoxemia
increased fingertip mass with increased curvature
Hypoxemia =
decreased O2 in arterial blood
Hypoxia =
decreased O2 to tissues
