Buzz Words Flashcards
mechanism of action of SSRIs
block reuptake of serotonin into presynaptic cell
best SSRI in adolescents
fluoxetine
what pathway does fluoxetine block
CYP450
best SSRI in epileptics
citalopram
safest SSRI in cardiac patients
sertraline
contraindicated drugs with SSRIs
triptans
NSAIDS
Aspirin
Warfarin
mechanism of action of TCAs
block reuptake of serotonin + noradrenaline into presynaptic terminals
mechanism of action of phenelzine
irreversible inhibition of monoamine oxidase enzymes – slows breakdown of noradrenaline + serotonin
mechanism of action of moclobemide
reversible inhibition of monoamine oxidase enzymes – slows breakdown of noradrenaline + serotonin
what is phentolamine used for
treatment of hypertensive crisis
what type of drug is lofepramine and imipramine
TCAs
what type of drug is venlafaxine
serotonin noradrenaline reuptake inhibitor
mirtazapine
NaSSA
-antagonises adrenergic receptors + blocks serotonin receptors
trazodone
given to treat sexual dysfunction caused by SSRI
mechanism of action of sodium valproate
increases GABA
mechanism of action of lamotrigine
blocks sodium channels - decreases glutamate release
typical antipsychotics
haloperidol
chlorpromazine
treatment of extra pyramidal side effects
procyclidine
mode of action of galantamine + rivastigmine
cholinesterase inhibitors
mode of action of memantine
blocks NMDA receptors
what is a jaw jerk a sign of
frontal cognitive syndrome
confusion, ataxia, ophthalmoplegia
thiamine deficiency
which area has strongest association with addiction
septal area
problem with broccas area
expressive aphasia
problem with wernicke area
receptive aphasia
trisomy 18
Edwards syndrome
IQ 70-84
Borderline learning disability
IQ 50-69
mild learning disability
IQ 35-49
moderate learning disability
IQ 20-34
severe learning disability
IQ <20
profound learning disability
PHQ-9 score
used to assess severity of depression
SADPERSONs
used to calculate suicide risk
oculogyric crisis
example of a dystonic reaction, involuntary prolonged upward deviation of the eyes
torticollis
example of a dystonic reaction- asymmetrical head/neck position
patient with alcohol dependence ‘staggering, confused, restricted eye movements’
wernicke’s encephalopathy
Korsakoff syndrome
patient acting strange, confabulating, short term memory problems
1st line for alcohol dependence relapse prevention
naltrexone
mode of action of naltrexone
opioid antagonist - reduces reward from alcohol
mode of action of acamprostate
acts of glutamate + GABA systems to decrease cravings
mode of action of disulfiram
inhibits acetaldehyde dehydrogenase
opioid overdose therapy
naloxone
dialectical behavioural therapy
borderline PD
Tx of Parkinson’s induced psychosis
clozapine
Tx of Parkinsons induced dementia
rivastigmine