Axiolytic Drugs Flashcards
what is GABA
the main inhibitory transmitter in the brain
action of GABA
causes hyper polarisation of target cells by increasing frequency of chloride channels
examples of benzodiazepines
diazepam
lorazepam
how do benzodiazepines work
they work by increasing GABA mediated inhibition – decreasing excitability of neurones
positive effects of benzo’s
reduced anxiety
muscle relaxation
anti-convulsant
side effects
dependence
sedation
respiratory depression in COPD patients
features of benzodiazepine withdrawal
insomnia irritability anxiety tremor decreased appetite tinnitus seizures delusions
how should Benzo’s be withdrawn
take them at night
reduce dose every 2-3 weeks
what drug reverses effects of benzodiazepine overdose
flumazenil
which antidepressant is 1st line in GAD
sertraline
which antidepressant is 2nd line in GAD
venlafaxine
which antidepressant is given 2nd line in panic disorder
TCA e.g. amytriptilline
mode of action of pregabalin
calcium channel blocker – enhances GABA
when is pregabalin given
anxiety unresponsive to other treatments + causing significant functional impact
