Burkholderia Flashcards

1
Q

Burkholderia are gram negative, aerobic rods that are ____ positive

A

catalse

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2
Q

What two species are important for Burkholderia?

A

B. mallei

B. pseudomallei

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3
Q

True/False: Burkholderia causes a pyogranulomatose disease

A

True

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4
Q

___ organisms of Burkholderia are necessary to cause diseaes. They are a category B agent and are _____

A

Few organisms are needed to cause disease

REPORTABLE

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5
Q

True/ False: Burkholderia mallei can be bioweaponized

A

True

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6
Q

What does Burkholderia mallei cause in horses?

A

Glanders

*can also affect other species such as cats but they are dead end hosts

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7
Q

True/ False: Horses are dead end hosts in Burkholderia mallei

A

False

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8
Q

Burkholderia mallei is a _____ disease

A

REPORTABLE

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9
Q

Burkholderia Mallei is characterized by the formation of nodules and ulcers in the ____ or skin

A

respiratory tract

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10
Q

What type of secretion system does Burkholderia Mallei use?

A

Type III and IV secretion system

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11
Q

What are the reservoir hosts for Burkholderia Mallei?

A

Equids- HORSES

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12
Q

Burkholderia Mallei is called a true ___ because it needs a host to survive and cannot live in the envrionment for very long

A

parasite

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13
Q

What is the main transmission for Burkholderia Mallei?

A

Ingestion of contaminated feed and water

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14
Q

What is common in males horses with Burkholderia Mallei?

A

Glanderous orchitis

*inflammation of the testicles

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15
Q

True/False: Burkholderia Mallei is normally a chronic, disseminated debilitating disease

A

True

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16
Q

When you see Glanders in the skin it is called ____

A

Farcy

*Cutaenous Glanders = Farcy

17
Q

True/False: Glanders is not fatal

A

False

*Acute infection tends to end fatally in about 2 weeks

18
Q

Farcy (skin abscesses) tend to occur in the ____ infection of Glanders

A

Chronic

19
Q

What are some signs of Glanders?

A

Fever, nasal discharge

20
Q

Is Burkholderia Mallei zoonotic?

A

YES- usually traced to an ill horse

21
Q

What disease does Burkholderia Pseudomallei cause?

A

Pseudoglanders

22
Q

Is Burkholderia Pseudomallei a reportable disease?

A

YES

23
Q

What are some differences between Burkholderia Mallei and Pseudomallei?

A

Pseudomallei has a higher tendency to disseminate

Pseudomallei is a saprophyte and can survive in the environment, while Mallei does not

24
Q

Burkholderia Pseudomallei are motile via ____

A

Flagella

25
Q

What bacteria causes Meliodiosis?

A

Burkholderia Pseudomallei

26
Q

Meliodosis is similar to Glanders but affects a ____ host range

A

wide

*but mainy sheep and goats

*severe in rodents

27
Q

How does melioidosis present in humans?

A

range from subclinical to rapidly fatal

28
Q

How does Pseudomallei perpetuate itself in the environment

A

Adheres to ameobas

29
Q

What secretion system does Burkholderia Pseudomallei have?

A

Type III and IV secretion system

30
Q

What is the reservoir for Burkholderia Pseudomallei?

A

soil and water (amoeba)

they like heavy rainfall

31
Q

Melioidosis is a more disseminated disease than Glanders and in humans is known as ____

A

Whitmores disease

*viatnamese time bomb- may develop disease months to years after infection

32
Q

Burkholderia pseudomallei is _____, while Burkholderia mallei is non _____

A

pseudomallei is motile

mallei is non motile

33
Q

What special agar is used with Burkholderia?

A

Cepacia Agar

34
Q

What does Burkholderia pseudomallei cause on MacConkey agar?

A

wrinkled colonies

35
Q

True/False: Once infected, an animal cannot become infected again with Burkholderia

A

False

*Those that recover are not protected

36
Q

For treatment of Glanders, Any animal that reacts to the screening tests should be ____

A

destroyed

37
Q

____ feeding and watering is discouraged for control of Glanders

A

communal

38
Q

Treating Equids with Glanders is ____

A

DISCOURAGED

*destruction of animals is the recommended course of treatment

39
Q

there are not commercial _____ available for Glanders or Melioidosis

A

vaccines