Burkholderia

Question 1

Burkholderia are gram negative, aerobic rods that are ____ positive

Answer 1

catalse

Question 2

What two species are important for Burkholderia?

Answer 2

B. mallei

B. pseudomallei

Question 3

True/False: Burkholderia causes a pyogranulomatose disease

Answer 3

True

Question 4

___ organisms of Burkholderia are necessary to cause diseaes. They are a category B agent and are _____

Answer 4

Few organisms are needed to cause disease

REPORTABLE

Question 5

True/ False: Burkholderia mallei can be bioweaponized

Answer 5

True

Question 6

What does Burkholderia mallei cause in horses?

Answer 6

Glanders

*can also affect other species such as cats but they are dead end hosts

Question 7

True/ False: Horses are dead end hosts in Burkholderia mallei

Answer 7

False

Question 8

Burkholderia mallei is a _____ disease

Answer 8

REPORTABLE

Question 9

Burkholderia Mallei is characterized by the formation of nodules and ulcers in the ____ or skin

Answer 9

respiratory tract

Question 10

What type of secretion system does Burkholderia Mallei use?

Answer 10

Type III and IV secretion system

Question 11

What are the reservoir hosts for Burkholderia Mallei?

Answer 11

Equids- HORSES

Question 12

Burkholderia Mallei is called a true ___ because it needs a host to survive and cannot live in the envrionment for very long

Answer 12

parasite

Question 13

What is the main transmission for Burkholderia Mallei?

Answer 13

Ingestion of contaminated feed and water

Question 14

What is common in males horses with Burkholderia Mallei?

Answer 14

Glanderous orchitis

*inflammation of the testicles

Question 15

True/False: Burkholderia Mallei is normally a chronic, disseminated debilitating disease

Answer 15

True

Question 16

When you see Glanders in the skin it is called ____

Answer 16

Farcy

*Cutaenous Glanders = Farcy

Question 17

True/False: Glanders is not fatal

Answer 17

False

*Acute infection tends to end fatally in about 2 weeks

Question 18

Farcy (skin abscesses) tend to occur in the ____ infection of Glanders

Answer 18

Chronic

Question 19

What are some signs of Glanders?

Answer 19

Fever, nasal discharge

Question 20

Is Burkholderia Mallei zoonotic?

Answer 20

YES- usually traced to an ill horse

Question 21

What disease does Burkholderia Pseudomallei cause?

Answer 21

Pseudoglanders

Question 22

Is Burkholderia Pseudomallei a reportable disease?

Answer 22

YES

Question 23

What are some differences between Burkholderia Mallei and Pseudomallei?

Answer 23

Pseudomallei has a higher tendency to disseminate

Pseudomallei is a saprophyte and can survive in the environment, while Mallei does not

Question 24

Burkholderia Pseudomallei are motile via ____

Answer 24

Flagella

Question 25

What bacteria causes Meliodiosis?

Answer 25

Burkholderia Pseudomallei

Question 26

Meliodosis is similar to Glanders but affects a ____ host range

Answer 26

wide \*but mainy sheep and goats \*severe in rodents

Question 27

How does melioidosis present in humans?

Answer 27

range from subclinical to rapidly fatal

Question 28

How does Pseudomallei perpetuate itself in the environment

Answer 28

Adheres to ameobas

Question 29

What secretion system does Burkholderia Pseudomallei have?

Answer 29

Type III and IV secretion system

Question 30

What is the reservoir for Burkholderia Pseudomallei?

Answer 30

soil and water (amoeba) they like heavy rainfall

Question 31

Melioidosis is a more disseminated disease than Glanders and in humans is known as \_\_\_\_

Answer 31

Whitmores disease \*viatnamese time bomb- may develop disease months to years after infection

Question 32

Burkholderia pseudomallei is \_\_\_\_\_, while Burkholderia mallei is non \_\_\_\_\_

Answer 32

pseudomallei is motile mallei is non motile

Question 33

What special agar is used with Burkholderia?

Answer 33

Cepacia Agar

Question 34

What does Burkholderia pseudomallei cause on MacConkey agar?

Answer 34

wrinkled colonies

Question 35

True/False: Once infected, an animal cannot become infected again with Burkholderia

Answer 35

False \*Those that recover are not protected

Question 36

For treatment of Glanders, Any animal that reacts to the screening tests should be \_\_\_\_

Answer 36

destroyed

Question 37

\_\_\_\_ feeding and watering is discouraged for control of Glanders

Answer 37

communal

Question 38

Treating Equids with Glanders is \_\_\_\_

Answer 38

DISCOURAGED \*destruction of animals is the recommended course of treatment

Question 39

there are not commercial _____ available for Glanders or Melioidosis

Answer 39

vaccines