Bullous Disorders

Question 1

what are bullous disorders?

Answer 1

AI diseases with damage to adhesion mechanisms

Question 2

examples of bullous disorders

Answer 2

1. pemphigus
2. pemphigoid
3. dermatitis herpetiformis

Question 3

AI component of pemphigus

Answer 3

IgG autoantibodies to desmoglein 3 so immune complexes form causing complement activation leading to acantholysis

Question 4

presentation of pemphigus

Answer 4

flaccid blisters that can burst easily to form erythematous erosions
found on scalp, face, axilla, groin, trunk and mucosal surface
chicken wire pattern

Question 5

AI component of pemphigoid

Answer 5

IgG react with basal cells on basement membrane

Question 6

presentation of pemphigoid

Answer 6

large tense bullae that are itchy and cannot burst
does not affect mucosal surfaces
often history of itch preceding onset of blisters

Question 7

what is dermatitis herpetiformis associated with?

Answer 7

coeliac’s

Question 8

presentation of dermatitis herpetiformis

Answer 8

itchy
symmetrical
lesions on elbows and knees

Question 9

AI association of dermatitis herpetiformis

Answer 9

IgA targets gliadin leading to papillary dermal micro-abscesses with IgA deposits (immune complexes)