Buffers Flashcards
What does a buffer do?
Resist change in pH when strong acids or bases are added in limited quantity
What is the buffer capacity?
Limit to the amount of acid/base that can be added before the buffer loses its ability to resist change
What does it mean in regard to the buffer if pH has changed?
Buffer has been destroyed
what body systems regulate blood pH through pH regulation?
Buffer system of the body combined with respiratory system and renal system
What are the 3 main buffer systems in the body?
Bicarbonate
Phosphate
Protein buffer systems
How does the respiratory system effect pH?
Directly impacts the carbonic acid buffer system through control of blood CO2 levels
How does the renal system effect pH?
Regulated by various buffer systems and works to remove H+ ions through the kidneys
What is Le Chatelier’s Principle?
When a system at equilibrium is disturbed, the system will adjust to reestablish equilibrium (adjusts in opposite direction to balance out)
What is produced if a weak base buffer is added to an acid?
More acid is produced
What is produced if a weak base buffer is added to a base?
produce more base
Drug are usually either _______ acids or ________ bases.
weak, weak
What form can cross membrane?
Unionized form–usually arent very soluble in water
What is the formula for % ionization?
(ionized form) / (ionized + unionized) x100
What type of drugs are better absorbed in the stomach?
Acidic drugs
What types of drugs are majority of local anesthetics?
Weak bases
