Bronchiectasis & CF Flashcards
What is Bronchietasis?
Chronic irreversible dilation of one or more bronchi
Which diagnostic investigation is used to identify Bronchiectasis?
High resolution CT
What is the Signet Ring Sign?
Where the bronchus is markedly dilated compared to its adjacent pulmonary artery (looks like a ring)
Name 3 symptoms of Bronchiectasis
Chronic cough, daily sputum production, haemoptosis, breathlessness on exertion
Name 3 causes of Bronchiectasis
Post infective, immune deficiency, idiopathic, alpha-1-antitrypsin deficiency, obstruction
Name 2 common causative organsims of Bronchiectasis
Haemophilus influenzae and Moraxella catarrhalis
What is chronic bronchitis?
Excess mucus secretion caused by smoking/air pollutants
What is the management for Bronchiectasis?
Physio airway clearance and regular sputum sampling
Define an exacerbation
A person with bronchiectasis with a deterioration in 3 or more key symptoms for at least 48 hours
What is the predominant mutation in Cystic Fibrosis?
Phe508del
What clinical presentations in CF?
Meconium ileus, intestinal malabsorption and recurrent chest infections
What is Orkambi?
Lumacaftor = CTFR chaperone and Ivacaftor = CTFR potentiator
