Breastfeeding Flashcards

1
Q

Describe: Lactogenesis I

A
  • Differentiation/development of glands to produce colostrum
    • Contains relatively high concentrations of Na, Cl, and protective substances like immunoglobulins and lactoferrin.
  • Occurs approximately midpregnancy (or 12 - 16 wks depending on the source)
  • Prolactin responsible for milk production
  • Milk secretion held in check by high progesterone and possibly estrogen
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2
Q

Define: Lactogenesis II

A
  • Usually about 3 - 8 days after birth (or 2 - 4 depending on source referenced)
  • Onset of copious milk production
    • By day 5, typically 500 – 750 mL/ day
    • By day 8, about 600 – 700 mL/day
  • Triggered by 10-fold drop of progesterone levels and increase in prolactin levels post placental expulsion
    • Change in several processes including:
      • Changes in the permeability of the paracellular pathway between epithelial cells
      • Changes in the secretion of protective substances, such as immunoglobulins, lactoferrin, and complex carbohydrates
      • Increased rate of secretion of all milk components

*

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3
Q

Describe the hormonal basis for lactation

A
  • Expulsion of the placenta → rapid decline in progesterone, estrogen, HPL → increased prolactin → milk production
    • Suckling/removal of milk from breast → even more prolactin
  • Other hormones involved too like cortisol and insulin
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4
Q

Describe normal breast anatomy

(start with nipple and go inward)

A
  • Tip of the nipple contains openings (pores of 15 to 20 milk ducts
  • Milk ducts (5-10 main ones) widen into lactiferous sinuses → lactiferous ducts → lobes
  • Lobes - clusters of alveoli
    • Alveolus - milk-secreting unit, surrounded by a rich vascular supply and smooth muscle myoepithelial cells.
      • Myoepithelial cells contract under the influence of oxytocin and push the milk down the ductwork to the nipple, (let down)
  • Breast is made up of glandular tissue (makes/transports milk) surrounded by fatty tissue and supported by fibrous tissue and suspensory ligaments (Cooper’s ligaments).
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5
Q

Hormones that induce breast development during pregnancy:

A
  • Progesterone
  • Prolactin
  • Human placental lactogen
  • Growth hormone
  • Insulin-like growth factor
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6
Q

Breast weight

(non-pregnant, pregnant, lactating)

A
  • Nonpregnant - 200 g
  • Pregnant - 400 - 600 g
  • Lactating - 600 - 800 g
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7
Q

NIpple anatomy

(non-pregnant, pregnant, lactating)

A
  • Size
    • Non-pregnant state: 15 – 16 mm
    • Pregnant state: > 5 cm
    • During lactation: 6.4 cm (average)
  • Each contain 14 – 18 lactiferous ducts
  • Has 4-9 pores that empty from the milk ducts to the surface.
    • Pores: 0.4 - 0.7 mm
    • Milk ducts: 2 - 4 mm
  • Contains erectile smooth muscle tissue which contract with stimulation.
  • Growth influenced by prolactin level increase
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8
Q

Areola anatomy

A
  • Center darker pigmented area of the breast
  • Size increases from 34 mm in early pregnancy → 50 mm postpartum
  • Montgomery glands (tubercles) - sebaceous glands that lubricate nipple and areola during infant suckling
    • Secrete antiinfective substances (IgA) that protect the nipple and areola
    • Wash away easily with soap or alcohol-containing compounds,→ nipple prone to cracking/infection
  • Pigmentation increases in pregnancy and postpartum
  • Growth influenced by hPL
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9
Q

What is a great determinant of breast size?

A

Adipose tissue

(also protects breast from injury)

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10
Q

Risk factors for delayed lactogenesis II

A
  • Overweight
  • Obese
  • Diabetic
  • Cesarean birth
  • Retained placental fragments
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11
Q

Contents, appearance and duration of:

  • Colostrum
A

Duration: Birth until milk comes in (Day 2 - 5)

Appearance: Yellow color from beta carotene, thicker than mature milk

Contents:

  • Higher in: protein, Na+, Cl-, K+, carotenoids, and fat-soluble vitamins (than mature milk)
  • Lower in: sugars, fat, and lactose (than mature milk)
  • Abundant amounts of antioxidants, antibodies, and immunoglobulins, with especially secretory IgA.
  • Interferon with its strong antiviral activity
  • Fibronectin - makes certain phagocytes more aggressive
  • Pancreatic secretory trypsin inhibitor (PSTI) - protects and repairs the delicate intestines of the newborn, preparing this organ to process future foods.
  • Mild laxative effect
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12
Q

Lactogenesis III and IV

A
  • Lactogenesis III
    • Day 9-10 postpartum until the mother and infant decide to wean
    • Stage of producing and maintaining milk production
  • Lactogenesis IV
    • Involution and cessation of breastfeeding
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13
Q

When should a breast-fed baby have returned to its birthweight?

A

10 days per Jamille (or 14 days, per Gabbe)

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14
Q

Where is prolactin secreted from?

A

Anterior pituitary

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15
Q

When do prolactin levels go back to normal, non-pregnant levels?

A

About a week after weaning

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16
Q

Where is oxytocin released?

A

Posterior pituitary in pulsitile waves as a result of sucking

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17
Q

What hormone causes the “let down” reflex and how does it work?

A

Oxytocin

  • Nipple stimulation → oxytocin release by posterior pituitary →
    • Contraction of myoepithelial cells eject the milk from the alveoli in the breast into the ducts → milk travels out into the nipple
    • Uterine contractions/cramping
  • Plays a role in maternal bonding (love hormone)
  • Increases pain tolerance
  • Stimulates growth in the # of intestinal villi → increasing surface area for caloric absorption
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18
Q

Physiology of weaning/decreased milk production

A
  • Colostrum/milk not removed from breasts → distended alveoli → pressure on blood vessels → reduced blood flow → prolactin can’t reach secretory cells
  • Lack of nipple stim → release of prolactin inhibiting factor → milk production gradually decreases
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19
Q

Contents, appearance and duration of:

  • Transitional milk
  • Mature milk
A

Transitional milk: Day 2- 5, may be yellow/gold but transitioning to blue/white

Mature Milk

  • Appears Day 2 - 5
  • 87.5% water, with all other components either dissolved, dispersed, or in suspension
  • Lipids/fats provide about 50% of the energy in milk
    • Fat content varies throughout a feeding or pumping session
      • Foremilk (early milk) is more dilute → thirst quencher
      • Hind milk has a higher fat content → thicker, “dessert”
    • Triacylglycerols most abundant fat
  • Doesn’t generally have enough Vitamin D → AAP recommends 400 IU/day after first few days of life
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20
Q

Infant stomach size

A

Baby needs less than a teaspoon of colostrum at each feeding in the first few days of life

21
Q

Describe the immunologic properties of breast milk

A

Major mechanisms for the protective properties of breast milk include:

  • Antimicrobial proteins: lactoferrin, sIgA, lysozyme, alpha- lactalbumin, lactadherin, defensins, and others.
    • Protect infant from a # of bacteria and also provide some protection from viruses and fungi
  • Human-specific oligosaccharides - blocks the binding of the microbe to the infant’s mucosal receptors, thereby limiting microbe virulence
  • Active leukocytes
22
Q

Identify the nutritional requirements of the lactating woman

A
  • Average lactating person puts out about 800 calories of breastmilk/day
  • Continue to take PNV - vitamin/mineral requirements still up
  • *Should take 1 g folic acid/day
  • *Vitamin D 600 IU
  • No general food restrictions as long as not allergic to certain foods and tolerates the food or beverage
  • Once lactation established, overweight women may restrict their energy intake by 500kcal/day to promote a weight loss of 0.5kg/week without affecting the growth of their infants
  • Moderate exercise ok
23
Q

Describe variations in nipples and breasts

A
  • Nipple inversion - congenital tethering of the nipple to underlying fascia
    • Dx by squeezing the outer edge of the areola → normally the nipple will protrude. Severe tethering is manifested by an inverted nipple. most severe forms of tethering occur in fewer than 1% of women.
    • Breast shells and Hoffman exercises dont help (per Gabbe)
  • Breast hypoplasia (glandular hypoplasia) very rare
    • Must wait until pregnancy (ie 36 weeks to really assess)
  • Previous breast surgery
24
Q

Describe different maternal and neonatal positions for breastfeeding

25
Describe characteristics of effective neonatal latch, suck and swallow
Characteristics of a correct latch: * Infant’s mouth opened wide enough (angle of corner of mouth = about 160°) * Nipple and at least 1/4 to 1/2" inch of areola drawn into the infant’s mouth and remain in place during sucking * The nipple should not be flattened, distorted, blanched, creased, or demonstrate blisters, fissures, or cracks when babe comes off * Swallowing should be either heard or seen * Both the upper and lower lips should be flared out (not rolled or tucked under) and form a complete seal with no leakage of milk at the corners of the mouth. * Cheek line should be smooth (not dimpled or drawn in) during sucking. * No smacking or clicking sounds during sucking (indicates that the tongue is losing contact with the nipple/areola)
26
Identify best practices to promote, assess and support the breastfeeding mother
All health-care providers should have basic core competencies in providing evidence-based breastfeeding care Helpful: * Prenatal information regarding the realities of breast- feeding * Practical help with positioning and latch-on * Provision of effective interventions for early problems * Evidence-based answers to questions such as how long and how often to breastfeed, when to switch breasts, and whether nipple shields and supplementing with bottles of formula will undermine breast- feeding. * Remaining with the mother during early feedings, assuring correct latch, and documenting milk transfer Unhelpful * Inconsistent advice about breastfeeding techniques * Quick intervention with a bottle when feeding diffculties present * Lack of skilled assistance * Rough handling of breast
27
Common breastfeeding problems: Low supply
* Medical causes: * Maternal hypothyroidism * PCOS * Previous breast surgery * Breast hypolplasia * Sheehan’s Syndrome * Retained placenta * Any reason that may limit the infant’s ability to breastfeed effectively and frequently * Poor latch * Early use of pacifiers * Prematurity, Late pre-term * Mother and infant being separated * NICU, employment * Supplementation with formula * Delayed milk ejection secondary to stress and pain * Maternal medications
28
Average infant weight loss by 72 hours of life?
7% shouldn't be \> 10%
29
Infant weight gain goals
15 – 30 g/day weight gain from day 5 – 2 months
30
Signs of adequate breastfeeding
* Audible swallowing sounds while breastfeeding * Adequate weight gain of \> 4 – 7 ounces/week after Day 4 * Adequate amount of wet diapers * Stools that transition from dark, tarry (meconium) to greenish, yellow to soft, seedy, yellow-mustard stools by the 5th day of life * Normal skin turgor
31
Non-pharm ways to increase milk supply
* Facilitate frequent feeding and oxytocin release * Skin-to-skin * Self-breast massage * Relaxation techniques * Help mother-infant dyad to achieve optimal latch-on * Emphasize unrestricted frequency and duration of BF * Advise mother to reduce or stop unnecessary supplementation * Address medical reason, if treatment available * Acupuncture has been successfully used in China since ancient times
32
Pharm methods to increase milk supply
Galactagoges: * Research on use inconclusive * Have potential side effects * If prescribing, counsel re: efficacy, timing of use, and duration of therapy * Monitor mother closely * Make peds aware * Prescribe lowest dose for shortest period of time * Gradual discontinuation **_Domperidone (Motilium)_** * 10 mg PO TID x 14 days * SE: drymouth, HA, abdominal cramps * May have "responders" and "non-responders" **_Metoclopramide (Reglan)_** * 10 mg PO TID or QID x 7-14 days * SE: sedation, anxiety, depression, agitation, gastric cramping, diarrhea
33
Herbals, foods, beverages to increase milk supply
* Not a lot of research, traditional use demonstrate safety and possibly efficacy * No standard dosing * Herbs * Fenugreek - 1200mg capsule 2-3x daily * Goat’s rue - 1 tsp of dried herb steeped in 1 cup of water BID or 1–2 mL of tincture TID * Milk thistle (Silybum marianum) * Oat, dandelion, seaweed, anise, basil, blessed thistle, fennel seeds, marshmallow, and many others. * Beer (alcohol could potentially lower production) * A barley component of beer (even nonalcoholic beer) can increase prolactin secretion, but not good studies
34
Treatments for flat or inverted nipples
* Breast Pump * Can be used to draw out the nipple immediately before breastfeeding * Evert-it Nipple Enhancer * Designed by lactation consultants, the Evert-It consists of a syringe with a soft, flexible tip made of silicone, either end of which may be used to provide suction to help nipples protrude for easier latch-on * Nipple stimulation before feedings * Roll nipple between the thumb and index finger for a minute or two. Afterwards, quickly touch it with a moist, cold cloth or with ice that has been wrapped in a cloth * Avoid prolonged use of ice, as numbing the nipple and areola could inhibit the let-down reflex.
35
Common breastfeeding problems: Sore nipples
Causes * Incorrect latching or unlatching * higher risk with flat/inverted nipples * Vasospasm (Reynaud-like phenomenon) – causes the baby to compress the breast so tightly as to interrupt blood flow to the nipple * Ankyloglossia Relief measures * Alter breast technique * Pain relief * Healing nipple skin * Lanolin * Hydrogel * Peppermint water * Interruption/Rest from breastfeeding
36
Common uses for nipple shield
* To improve latch-on when mother has flat nipples. * To overcome latch-on problems due to engorgement. * To assist infants who are nipple confused, preferring an artificial nipple to the mother's breast. * To aid premature infants with tiny mouths, reduced or impaired suck mechanisms, or other physical challenges. * To protect sore or damaged nipples. * To prevent sore nipples (claimed by manufacturers but not proven)
37
Common breastfeeding problem: Yeast infection of breast
* Due to Candida albicans * Symptoms: * Superficial nipple pain * Deep breast pain * Shooting, burning, stabbing pain * Red, shiny, flaky areola * Treatment * Topical Miconazole 2% - remove excess * Gentian violet painted on areola and nipples – 0.5 – 1.0% strength for 4 – 7 days (potential for toxicity if used for a long period of time). * Dilution pf 0.25% - 0.5% can be used on infant’s mouth 1-2 x daily fro 3 – 7 days * Fluconazole 400 mg loading dose then 100 mg BID x 14 days * Newman’s APNO ointment (mupirocin 2%, betamethasone 0.1%, miconazole powder) – apply sparingly after each feeding until pain free (dont wash off)
38
Common breastfeeding problem: Plugged duct
* Tender small lumps in breasts usually related to the blockage of a milk duct * Possibly due to large milk supply or pressure from outside the breasts (from bra straps, backpack, purse straps) resulting in a physical obstruction of milk flow and a large collection of milk products * Management: * Warm compress * Direct massage over the lump while infant is suckling * Prompt attention needed to prevent cascade of engorgement and mastitis * Lecithin (phospholipid used by food industry as an emulsifier to keep fat dispersed and suspended in water rather than aggregated in a fatty mass). 1 tbsp/day of oral granular lecithin has been reported to relieve plugged ducts and prevent their recurrence
39
Common breastfeeding problems: Engorgement
* Typically occurs 3 to 5 days after birth (or first 2 wks) * Breasts are swollen, firm, tender, and warm to touch * Sudden increase in milk volume, lymphatic and vascular congestion, and interstitial edema * Milk production increases rapidly → milk volume outpaces capacity of alveoli to store → alveolar overdistension → * Flattens milk-secreting cells (can rupture) * Capillary blood circulation surrounding the alveolar cells partially or completly occluded. * Congested blood vessels leak fluid into the surrounding tissue space,→ edema → obstruct lymphatic drainage → predisposed to mastitis * Makes it hard to feed, very painful * Treatment: * Feed Q2H, feeding through the pain * Feed on 1st breast until it softens before switching to other side * Warm shower or warm packs before feeding to relax ptlet-down * Massage to soften breast * Ibuprofen to reduce pain and swelling * Chilled cabbage leaves in bra (evidence mixed)
40
Common breastfeeding problems: Mastitis (symptoms and predisposing factors)
* Tender, hot, swollen, wedge-shaped area of breast associated with a temperature of \>101° F, chills, flu-like aching and systemic illness. * Occurs most frequently in the first 2-4 wks pp * Predisposing factors: * Nipple trauma, especially if colonized with Staphylococcus aureus * Infrequent feedings or scheduled frequency or duration of feedings * Maternal stress and fatigue ( and not feeding infant as much) * Poor nursing technique – weak latch, uncoordinated suckling, inefficient removal of milk * Oversupply of milk * Rapid weaning * Blocked nipple or duct * Nipple piercing * Insulin dependent diabetes
41
Common breastfeeding problems: Mastitis (Supportive measures)
* Effective milk removal * Rest * Fluids * Nutrition * Practical help around the house to allow mother to have adequate rest * Application of heat (hot shower or hot pack) prior to breastfeeding * Cold packs in between feedings
42
Common breastfeeding problems: Mastitis (Pharm management)
* Analgesia such as acetaminophen and ibuprofen * Antibiotics * Non-severe infection without risk for MRSA: * Cephalexin [Keflex] 500 mg QID x 10 -14 days * Dicloxacillin [Dynapen] 500 mg QID x 10 – 14 days * Clindamycin 300 mg QID x 10 – 14 days * Non-severe infection WITH risk for MRSA: * Trimethoprim-sulfamethoxazole (Bactrim) 1 – 2 tabs BID * Cephalexin [Keflex] 500 mg QID x 10 -14 days * Severe infection: Intravenous therapy * Vancomycin 30 mg/kg IV in two divided doses Q 24 hours
43
Common breastfeeding problems: Mastitis (Follow up, complications)
* If sx do not resolve within several days of management, consider differential dx: resistant bacteria, abscess formation, underlying mass, or inflammatory or ductal carcinoma * Complications * Early cessation of breastfeeding * Abscess * Candida infection * Recurrance/resistance - milk culture, infant naso/oropharynx culture
44
Common breastfeeding problems: Breast abscess
* Localized collection of pus in breast tissue * Most common organism: staph aureus (60% MRSA) * Ultrasound: rounded anechoic image with defined walls. * Management: * Drainage and antibiotic therapy * Needle-point aspiration * Surgical drainage * Complication of surgical drainage: * Milk fistula * Poor cosmetic outcome
45
Common breastfeeding problems: Fussy baby
* _Pain from birth injuries_ - be careful about positioning * Vacuum extraction associated with poor feeding/breastfeeding cessation by 10 days) * _Oral aversion_ - from NICU care like suctioning, intubation, or just soreness of mouth * Have baby cuddle, play at breast, try cup feeding * _Pre/perinatal medication_ - hypertonia and * Ilicit drugs - irritibility, thrashing, clamp down on nipple, nasal stuffiness * Tobacco - excitability, need holding * SSRIs - agitation, tremors, irritability, and sleep disturbances → try to feed drowsy, low stim * _Hunger_ - poor feeding or limited milk transfer
46
Common breastfeeding problems: Sleepy baby
* Not an indicator that an infant has received enough milk * Sleep more: late preterm, jaundice (including those undergoing phototherapy), born by c-section, and heavier infants of diabetic mothers * May be related to the normal release of cholecystokinin (CCK) - occurs with breastfeeds. * GI hormone released in response to fat * Enhances gut maturation, promotes glucose-induced insulin release, enhances sedation, thought to play a role in regulating food intake by signaling satiety * Keep skin-to-skin as much as possible during the day * Feeding can be subtle: * Rapid eye movements under the eyelids * Tongue, hand-to-mouth, or body movements, * Small sounds * Can use supplemental nursing system
47
Common breastfeeding problems: Slow weight gain
Factors associated with slow weight gain: * Gestational age * Size for gestational age * Oral malformations - cleft lip/palate * Neuro alterations * Increased energy requirements - cardiac disease, respiratory disease, and metabolic disorders * Infant illness or condition * Maternal medications * Intrapartum factors - cesarean birth, fetal hypoxia during labor, maternal medications during labor, epidural analgesia, forceps delivery, and vacuum extraction that may interfere with alertness and ability to feed * Iatrogenic - ie separation Supplemental feedings breast milk are ideal if supply is suffcient. Start with a minimum of 50–100mL/kg/day divided into 6 to 8 feedings
48
Common breastfeeding problems: Preterm and late preterm infants
* Breast milk is very important * Should begin pumping within 6 hours of birth * Late preterm infants: * Born with low energy stores, high energy demands, and poor feeding ability * Sleepy/tire easily when feeding * Weak suck and low tone * Easily overstimulated * More prone to positional apnea due to airway obstruction * Should be breastfed in a clutch, cross-cradle, or ventral position * May need to pump for weeks or months until infant can breastfeed or to provide as much breast milk for as long as possible. * Need to have an effcient, automated hospital-grade pump that cycles ~ 48–50 times per minute, with vacuum that does not exceed 240 mmHg. * Double collection kit that pumps both breasts simultaneously and fits properly should be used. * Pump more milk faster when double pumping, esp w/ breast massage.