Breastfeeding Flashcards
what comprises a glandular unit?
alveolus: cluster of epithelial secretory cells around a lumen
ductules terminate in lumen of alveoli
myoepithelial cells surround each alveoli and eject milk into ductules
one duct has how many lobes? each lobe has how many lobules? each lobule has how many alveoli?
one duct has 15-20 lobes
each lobe has 20-40 lobules
each lobule has 10-100 alveoli
five phases of lactation?
embryogenesis mammogenesis: begins in childhood, accelerates in puberty, PG is final stage lactogenesis galactopoiesis involution
when does mammogenesis start? when is the breast capable of producing milk? what hormones have to do with milk production?
mammogenesis starts right after conception
breast is capable of producing milk at 16-20 wks
estrogen, progesterone, placental lactogen, prolactin and oxytocin all have to do with milk production
what does estrogen have to do with mammogenesis?
increases sensitivity to prolactin and PL
stimulates mammary growth and development
promotes lactation secretion by anterior pituitary
what does progesterone have to do with mammogenesis?
enhances lobuloalveolar development
inhibits milk secretion during PG
what does placental lactogen have to do with mammogenesis?
glandular tissue of alveoli
what does prolactin have to do with mammogenesis?
acts w/other hormones to stimulate development of alveoli and ductal system
effects of oxytocin on mammogenesis?
no effect on mammary development
sensitivity of myoepithelial cells in PG
enzyme from placenta keeps levels low
what is lactogenesis? when does it begin? suppressed by what hormones? triggered by fall of what 2 hormones? how many days to complete? predominate hormone to trigger it?
initiation of milk production begins before birth, secretion suppressed by progesterone triggered by fall of E and P 4 days to complete prolactin predominating hormone
what causes milk production and release?
controlled by suckling
what does suckling cause?
prolactin release from anterior pituitary and stimulates nipple/areola which sends impulses to hypothalamus
role of hypothalamus in lactogenesis?
decrease prolactin inhibiting factor
what happens to prolactin levels at the end of feeding?
increase at end of feed which increases milk volume, fat and protein in next feeding
what are levels of prolactin at during week 1? week 2-3 mos? after 3 mos?
week 1: base levels high, slight increase with suckling
week 2-3 mos: base levels 2-3x higher and suckling levels 10-20x higher
after 3 mos: base levels similar to non-lactating and do not rise much with suckling
is volume of milk related to prolactin?
nope
how does feedback inhibitor of lactation work?
when milk is left in breast there is activation of milk protein feedback inhibition of lactation
possibly decrease breast sensitivity to prolactin
stretch response
what is galactopoiesis? what is it dependent on?
maintenance of lactation
dependent on periodic suckling, removal of milk, intact hypothalamus/pituitary
oxytocin
what is the purpose of oxytocin?
milk ejection reflex or let down reflex via contraction of myoepithelial cells of alveoli
what causes the release of oxytocin?
sucking response triggers the hypothalamus to trigger the posterior pituitary to release oxytocin
what is oxytocin release stimulated by? what is oxytocin release reduced by?
oxytocin release stimulated by: thinking of the infant, hearing a crying baby, suckling, orgasm
oxytocin release reduced by: anxiety, stress, pain, fatigue, alcohol
5 mechanisms of milk production?
4 unidirectional (blood to milk), one paracellular/bidirectional (plasma, intact proteins, WBCs, degraded cells)
what is colostrum? what is it made up of? when does it appear and how long does it last?
colostrum- appears in 2nd TM, last 2-3 days PP, higher in protein 3x (AA, IgA, lactoferrin)
lower in CHOs, fat, calories
3 “types” of milk?
colostrum
transitional milk
mature milk replaces transitional 1-2 wks
how many calories are in an ounce of milk?
20 kcal in 1 ounce
protein characteristics of milk?
lower protein than cow’s milk so less load on the KDs
casein: whey 40:60
enzymes: anti-infective, digestive enzymes
high in immunoglobulins: sIgA is the highest then IgG, then IgM, no IgE in human milk
carbohydrate concentration in milk?
lactose: 6.8 g/dL
glucose: 14 mg/ 100 mL
galactose: 12mg/ 100 mL
fructose: important in establishing fibidus
nucleotides in milk?
cytidine, adenine, uridine
fat content of milk? factors which can affect fat content of milk?
3.5-4.5 g/100 mL
factors which affect content include: prenatal wt gain, length of gestation, parity, volume of milk, timing of feeding
higher linoleic acid than cow’s milk
amount of fat minorly influenced by diet but type of fatty acids can be affected
where is the majority of calcium from in milk?
maternal blood mostly from bone stores
cannot be raised by nutritional intake but can preserve bone stores in mom
how do breastfed babies iron stores compare to those that are not breastfed? purpose of ferritin in a baby?
breastfed babies have higher ferritin
lactoferrin inhibits bacterial growth in baby GI