breast pathology Flashcards
1
Q
HER2
A
Epidermal growth factor receptor with intracellular tyrosine-kinase activity that promotes cell growth and differentiation and inhibits apoptosis
analysis with immunohistochemical staining
2
Q
HER2 + breast cancer treatment
A
Trastuzumab - therapeutic receptor inhibition, helps slow cancerous growth and decrease cancer mass
SE: cardiotoxicity (dilated cardiomyopathy)
3
Q
triple negative
A
hormone receptor negative and HER-2 negative
most common in african american women
more aggressive, high grade
4
Q
Paget disease
A
Ductal carcinoma presenting as an eczematous nipple lesion, may have bloody discharge
5
Q
masses are most common in
A
upper outer quadrant
