Brain maturation and aging Flashcards

1
Q

In the brain, what increases as the animal matures?

A

Degree of myelination
Dendrites increase in number
Number of synapses

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2
Q

What is developmental learning?

A

Brain development depends on the external environment the animal is exposed to

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3
Q

Brain maturation involves which 4 processes?

A
  • Mitosis and apoptosis of neurones
  • Development of synapses
  • Myelination
  • Strength of connectivity
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4
Q

What are sensitive periods?

A

Certain times during development in which the NS is more likely to be affected by developmental learning

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5
Q

In dogs, at what age is the first critical period for socialisation?

A

3 weeks

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6
Q

If the first social contact occurs after a critical period what will the animals response be?

A

Fear

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7
Q

How does learning occur and what does it require?

A

As a consequence of experience
Requires motivation and attention
Relies on the ability to form memories

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8
Q

Describe the 2 ways memory can be considered

A

Declarative - specific facts which may result from a single experience
Procedural - motor skills resulting from repetitive training

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9
Q

Describe short term memory

A
  • seconds to hours in duration
  • electrical memory trace only
  • limited storage capacity
  • must be rehearsed to be consolidated
  • easily forgotten
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10
Q

Describe long term memory

A
  • Days to years in duration
  • Physical memory trace
  • Infinite capacity
  • Constantly refined in light of new related STMs
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11
Q

How are memory traces different in STM and LTM?

A

STM: Electrical only
LTM: Physical change - formation of new synapses, growth of dendrites

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12
Q

What are the two types of non-associative learning by which STMs are formed?

A

Habituation and Sensitisation

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13
Q

What is habituation?

A

Natural response to a stimulus that reduces over time

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14
Q

What is sensitisation?

A

Natural response to a stimulus increases over time

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15
Q

What is associative learning?

A

STM processing before the learned is stored in the LTM

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16
Q

What are the two types of associative learning?

A

Operant conditioning

Classical conditioning

17
Q

What is operant conditioning?

A

Animal learns to associate behaviours with outcomes

18
Q

What is classical conditioning?

A

Animal learns to associate two stimuli that produce a desirable behaviour

19
Q

Which degenerative process is often referred to as brain ageing?

A

Cognitive dysfunction syndrome

20
Q

What does cognitive dysfunction syndrome involve?

A

Ability to think and process information and manipulating knowledge through learning, memory and planning is lost

21
Q

What are the signs of cognitive dysfunction syndrome?

A

DISHA:

  • Disorientation
  • Interaction and social behaviour changes
  • Sleep/wake cycle changes
  • House soiling
  • Activity level changes
22
Q

What is cognition?

A

The ability to think and process information

23
Q

What happens in brain atrophy?

A
  • Widening of the sulci
  • Thinning of the gyri
  • Reduced neural density
24
Q

What are the 4 hallmark neuropathological changes of cognitive dysfunction syndrome?

A
  • Brain atrophy
  • Senile plaques (protein plaques around neurones)
  • Oxidative damage
  • Neurofibrillary tangles
25
Q

What is a very common presenting sign of cognitive dysfunction syndrome?

A

Aggression