BPH

Question 1

What hormone cause BPH

Answer 1

Dihydrotestosterone and oestrogen

Question 2

What are the medications for BPH

Answer 2

5-alpha reductase inhibitor (dutasteride/finasteride) [target static patho of BPH]
Alpha 1 blocker (prazosin, tamsulosin, alfuzosin) [target dynamic patho of BPH]

Question 3

What are the medications in 5-alpha reductase inhibitors

Answer 3

Dutasteride and Finasteride

Question 4

What are the medications in Alpha 1 blockers

Answer 4

Prasozin, Tamsulozin and Alfuzosin

Question 5

MOA of 5-alpha reductase inhibitors

Answer 5

Reduce size of prostate gland by blocking 5-alpha reductase to prevent production of growth hormone dihydrotestosterone from testosterone

Question 6

How long does it take to see symptom relieving effects of 5-alpha reductase inhibitors

Answer 6

3-6mths

Question 7

MOA of Alpha 1 blockers

Answer 7

Relax neck muscle of bladder and muscle fibre near prostate to relieve pressure on urethra which makes emptying of bladder easier

Question 8

What are Alpha 1 blockers also for

Answer 8

Men with urge incontinence or overflow incontinence