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Pharm > Box 3 Meds > Flashcards

Box 3 Meds Flashcards

1
Q

Labetalol (Normodyne, Trandate) Class

A

Non-selective beta adrenergic blocker (w/ some alpha 1-blocking properties)

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2
Q

Labetalol (Normodyne, Trandate) MOA

A

Competitive beta receptor antagonist & prevent actions of catecholamine and other beta agonists

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3
Q

Labetalol (Normodyne, Trandate) Dosage

A

IV: 0.1-0.5 mg/kg (20-80 mg bolus q 10)

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4
Q

Labetalol (Normodyne, Trandate) characteristics

A

O: 5 min or less

P: 5-15 min

D: 2-6 hrs

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5
Q

Labetalol (Normodyne, Trandate) E/M

A

M: conjugation w/ glucuronic acid (hepatic)

E: renal

H/t: 5-8 hrs

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6
Q

Labetalol (Normodyne, Trandate) considerations

A

Provides b blockade in a 7:1 ratio IV but 3:1 PO

Elimination prolonged in liver dz but unchanged in renal

Contra: bronchospasm, 1 degree HB, cardio genic shock, obs. airway dz, severe bradycardia

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7
Q

Metoprolol (Lopressor, Troprol XL) Class

A

Selective B1-adrenergic antagonist (cardioselective)

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8
Q

Metoprolol (Lopressor, Toprol XL) MOA

A

Prevents inotropic & chronotropic response to B-adrenergic stimulation.

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9
Q

Metoprolol (Lopressor, Toprol XL) Dosage

A

IV: 1-15 mg

PO: 50-400mg

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10
Q

Metoprolol (Lopressor, Toprol XL) characteristics

A

O: 1-5 min

P: 20 min

D: 5-7 hrs

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11
Q

Metoprolol (Lopressor, Toprol XL) E/M

A

Undergoes first pass hepatic met. so only 40% reaches circulation

h/t: IV 3-7 hrs
PO tartrate: 2-3 hrs
PO succinate: 5-7 hrs

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12
Q

Metoprolol (Lopressor, Toprol XL) considerations

A

Caution w/ high doses in ch obstructive airway and hypoglycemic

Contra: AV HB, acute cardiac failure caused by tachycardia, hypovolemic pts w/ compensatory tachycardia (can cause resistant hypotension)

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13
Q

Neostigmine (Prostigmin) class

A

Anticholinesterase inhibitor

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14
Q

Neostigmine (Prostigmin) MOA

A

Inhibits AChE so that ACh accumulates at NMJ & competes w/ nondepolarizing NMB for unoccupied nicotinic ACh receptors

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15
Q

Neostigmine (Prostigmin) dosage

A

Most common 40-70 mcg/kg

MAX: 5mg

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16
Q

Neostigmine (Prostigmin) E/M

A

Renal excretion 50%

17
Q

Neostigmine (Prostigmin) considerations

A

MUST have at least 1 twitch first.

To minimize muscarinic CV effects, an anticholinergic (glycopyrrolate 7-15mcg/kg) should be coadministered

Caution in brady, bronchial asthma, epilepsy, arrhythmia, peptic ulcer, peritonitis, mechanical obs of intestines

18
Q

Robinul (Glycopyrrolate) class

A

Systemic cholinergic antagonist

19
Q

Robinul (glycopyrrolate) MOA

A

Blocks effects of ACh at parasympathetic sites.

Reduces rate of salivation by preventing stimulation of ACh receptors

20
Q

Robinul (glycopyrrolate) Dosage

A

IV: 7-15 mcg/kg

21
Q

Robinul (glycopyrrolate) characteristics

A

O: IV 2 min; IM/subq 15-30 min

P: 30-45 min

D: 2-4 hrs

22
Q

Robinul (glycopyrrolate) E/M

A

Feces (15%), urine (85%)

23
Q

Robinul (glycopyrrolate) considerations

A

Unlikely to pass BBB, GIT, or placenta d/t ionization (insoluble in lipids)

Mod increase in HR (

24
Q

Robinul (glycopyrrolate) supply

A

0.2mg/ml or 0.4mg/ml

25
Q

Zofran (ondansetron) class

A

Antiemetic (5-HT3 serotonin receptor antagonist)

26
Q

Zofran (Ondansetron) MOA

A

Serotonin is released in sm. Intestine stimulating vagal affronts through 5-HT3 receptors initiating vomiting.

5-HT3 antagonist block these receptors preventing N/V

Do not treat N caused by vestibular stimulation

27
Q

Zofran (Ondansetron) dosage

A

IV 4-8 mg over 2-5 min before ind & after procedure

Peds: PO 0.15 mg/kg; IV 0.05-0.15mg/kg (max 4mg)

28
Q

Zofran (Ondansetron) characteristics

A

O: 30-60 min

P: 1-1.5 hrs

D: 4-6 hrs

29
Q

Zofran (Ondansetron) E/M

A

M: CYP 450
E: renal

H/t: 3-4 hrs

30
Q

Zofran (ondansetron) considerations

A

Prolonged QT

Serotonin syndrome possible

S/E headache & diarrhea

Contra: hypermagnesemia (can cause torsades)

31
Q

Zofran (Ondansetron) supply

A

4mg/2ml

32
Q

Neostigmine (Prostigmin) characteristics

A

O: 5-10 min

P:

D: 45-90 min

Pharm (15 decks)

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