Botulinum Toxin

Question 1

How’s it work?

Answer 1

binds presynaptically to the high affinity recognition site on the cholinergic nerve terminals –> decreasing release of Ach

Question 2

what is the result of botulinum toxin

Answer 2

hypotonia and/or flaccid muscle depending on the dose

Question 3

what can therapists work on during the period of hypotonia

Answer 3

• improving flexibility in contracted muscles

Question 4

How long does treatment last?

Answer 4

3-4 months

Question 5

complications

Answer 5

dependent on the muscles injected and higher risk for muscle in the head/neck and trunk

Question 6

adverse events

Answer 6

• weakness of unintended muscles, flaccidity, dysphagia, local hematoma, generalized fatigue, dizziness, dry mouth, pain, and flu like symptoms