Bordetella pertussis Flashcards

1
Q

Características

A

-cocobacilos gram negativos

-Aerobios estrictos

-8 especies, 4 patogenas

-Cultivo prolongado en medios especiales:
Bordet-gengou
Regan-lowe

-Dx por PCR

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2
Q

4 patogenas

A

B. Pertussis
B. Parapertussis
B. Bronchiseptica
B. Holmesii

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3
Q

Mecanismos de Patogenia

A
  1. Adherencia
  2. Exotoxinas
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4
Q

Adherencias

A

Pertacnina, hemaglutimina filamentosa, fimbrinas

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5
Q

Exotoxinas

A
  1. PERTUSSIS: incrementa el AMPc y promueve las secreciones respiratorias
  2. TRAQUEAL:destruye células ciliadas o los paraliza
  3. Adenilciclasa: inhibe la quimiotaxis y fagocitosis
  4. Dermonecrótica: destruccion tisular
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6
Q

Enfemedades

A

Sindrome coqueluchoide - tos ferina - whopping cough

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7
Q

Tos ferina

A

Cuadros en los cuales la causa es la bordetella pertussis

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8
Q

Sx coqueluchoide

A

Los niños tienen tos en accesos espasmodicos (tosen una y otra vez sin poder respirar) + estridor respiratorio

Lactantes y niños pequeños

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9
Q

Tx

A

macrolidos
Poco desarrollo de resistencia

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10
Q

Vacuna

A

mujeres embarazadas
Adolescencia

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