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Basic Tissues > Bone marrow Hematopoiesis > Flashcards

Bone marrow Hematopoiesis Flashcards

1
Q

Hematopoiesis

A

Process of blood cell renewal

All blood cells are derived from hematopoietic stem cells (HSCs)

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2
Q

Prenatally

A

2-10 weeks gestation: yolk sac

primary hematopoietic organ prenatally is the liver

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3
Q

Postnattally

A

Primary organ for hematopoiesis is the bone marrow

Secondary organ is the lymphatic organs

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4
Q

Hematopoietic Stem Cells (HSCs)

A

pluripotential- Hematopoietic stem cells have the ability to give rise to all different mature blood cell types

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5
Q

Hematopoietic stem cells (HSCs) give rise to 2 types of multipotential cells

A

1) Common myeloid progenitors (CFU GEMM)
2) Common lymphoid progenitors (CFU L)

morphologically identical to HSCs but limited capacity for self renewal

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6
Q

CFU-GEMM gives rise to

A

myeloid cells -myelopoiesis

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7
Q

CFU-L gives rise to

A

lymphoid cells- lymphopoiesis

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8
Q

Erythropoietin

A

activation of erythroid cells

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9
Q

Thrombopoietin

A

stimulation of platelet production

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10
Q

Erythropoiesis

A

production under control of erythropoietin

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11
Q

Progenitors

**know

A

HSC –> CFU-GEMM –> BFU -E —> CFU E

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12
Q

Stages of erythroid (red cell) maturation

***KNOW

A

1) Proerythroblast
2) Basophilic erythroblast
3) Polychromatophilic erythroblast
4) Orthochromatiphilic erythroblast
5) Reticulocyte
6) Erythrocyte

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13
Q

Start w/ hematopoietic stem cell –>

A

CFU- GEM –> CFU GM or EO-BA -> Myloblast -> promylocyte -> mylocyte -> metamylocyte -> band or stab cell -> neutrophil (mature cell)

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14
Q

CFU GEMM turns into

A

CFU MEG under influence of GM CSF and IL3

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15
Q

CFU Meg

A

Megakaryoblast

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16
Q

Lymphopoiesis

A

HSCs give rise to CFU- Ly progenitor cells in the lymphoid series
CFU-Ly forms CFU-LyB and CFU-LyT progenitor cells

17
Q

CFU-LyB/CFU-LyT

A

—> Lymphoblasts

18
Q

What are lymphoblasts

A

large cells capable of cell division

differentiate into prolymphocytes aka smaller cells

19
Q

For lymphocytes they start with…

**KNOW

A

HSC and differentiate into CFU-L
which differentiates into CFU LB and CFUL-T
and they differentiate into lymphoblasts, pro lymphocytes, lymphocytes

20
Q

Monocytopoiesis

A

Originate in BM from CFU-GEMM

CFU-GEMM –> CFU GM

Basic Tissues (11 decks)

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