Bone cells Flashcards
Understand what the bone cells are and there role in bone formation.
What are Osteogenic cells ?
These are stem cells found in the periosteum and bone marrow.
What do osteogenic cells divide and differentiate into ?
Osteoblasts.
What are Osteoblasts ?
These cells build bone in initial bone formation and later bone remodelling.
Where are Osteoblasts found ?
Periosteum.
What do Osteoblasts produce ?
Collagen and Calcium.
What do Osteoclasts do?
They break down bone.
How would you describe an Osteoclast ?
A Large multinucleated cell.
What enzyme do Osteoclasts produce to break down bone ?
ACID PHOSPHATASE.
why is bone described as a dynamic tissue ?
It is continuously being broken down and restructured in response to structural stress and the body’s need for calcium.
What is an Osteoid ?
Osteoblasts secrete a matrix material called Osteoid.
Once the Osteoid is laid out what happens to create the mineralised bone we know ?
Inorganic salts comprising of calcium and phosphorus are deposited in it to form hardened bone.
briefly describe the process of bone formation ?
- Osteogenic cells divide and differentiate into Osteoblasts.
- Osteoblasts found in the Periosteum build bone.
Osteoblasts secrete a matrix material called Osteoid. - Inorganic salts comprising of calcium and phosphorus are deposited in it to form hardened bone.
- As this is happening Osteoclasts are involved in the break down of bone. They use an enzyme Acid phosphatase to do so.
